Prenatal Tarama Testleri ve Hücreden Bağımsız Fetal DNA

Year 2020, Volume: 27 Issue: 2, 254 - 260, 01.06.2020

Fevziye Burcu Şirin

https://doi.org/10.17343/sdutfd.605545

Cited By: 1

Abstract

Prenatal tarama
testlerinin kullanım amacı gebeliğin erken haftalarında kromozomal anöplöidi
açısından yüksek risk taşıyan gebelerin tesbit edilmesi ve her gebenin mevcut
riskleri ve tercihleri göz önünde bulundurularak bilgilendirilmesidir. Son
yıllarda prenatal tarama testleri geleneksel prenatal tarama testleri ve
hücreden bağımsız fetal DNA (cffDNA, fetal DNA, NIPT) olarak ikiye
ayrılmaktadır. Maternal kandan biyobelirteçlerin ölçülüp
ultrasonografik bulgularla kombine edildiği geleneksel prenatal tarama testleri
halen birinci tercih olarak önerilmektedir. cffDNA ile gebeliğin 10.
haftasından itibaren maternal kanda yeni nesil sekanslama teknikleri
kullanılarak fetal DNA fragmanları analiz edilmektedir. Günümüzde hangi
popülasyona cffDNA testinin önerileceği, klinik kullanımda faydası, maliyeti,
limitasyonları ve avantajları  tartışmalı bir konudur.

Keywords

prenatal tarama testleri, fetal DNA, cffDNA

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