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EVALUATION OF THE RELATIONSHIP BETWEEN MPV AND SEVERITY OF CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS WITHOUT ACUTE CORONARY SYNDROME

Year 2021, Volume: 28 Issue: 3, 411 - 417, 13.09.2021
https://doi.org/10.17343/sdutfd.820120

Abstract

Objective
Since many studies focused on the relationship
between mean platelet volume (MPV) and severity of
type 2 diabetes mellitus (T2DM) or investigated MPV
and coronary artery disease (CAD) mostly on acute
coronary syndrome (ACS), this study primarily focused
to investigate if MPV values have any relation with
different levels of CAD specifically in T2DM patients,
who had no previous coronary artery disease, and no
ACS history.
Materials And Methods
T2DM patients who had first coronary angiography
(CAG) between November 2019 and February
2020, and whose after night fasting blood tests
were performed before CAG were included. Two
cardiologists, blinded to the patients, evaluated
angiographies. Patients have divided into groups
accordingly; normal coronary artery (Group 1),
non-critic stenosis (Group II), and severe CAD
(Group III) according to the Gensini score. Patients’
demographics, heart rate, risk factors of CAD, and
blood test including MPV were also collected.
Results
A total of 180 patients (88 female, 92 male) were
involved in the study. There was no significant relation
between MPV and the severity of CAD in T2DM
patients (p=0.228). The mean age of the Group I group
was significantly lower than in other groups (p=0.228),
and there were significantly lower males in Group I
than other groups (p=0.0001). The triglycerides levels
were significantly low in Group I than in other groups
(p=0.021 and p=0.006).
Conclusion
MPV values were not associated with the severity
of CAD in stable patients. Older age, male gender,
higher levels of triglycerides, and initial glucose levels
were significantly related to the severity of CAD in
T2DM patients.

References

  • 1. Emerging Risk Factors C, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375(9733):2215-22.
  • 2. Lorber D. Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2014;7:169-83.
  • 3. Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications. 2009;23(2):89-94.
  • 4. Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J. 2008;49(2):114-6.
  • 5. Budzianowski J, Pieszko K, Burchardt P, Rzezniczak J, Hiczkiewicz J. The Role of Hematological Indices in Patients with Acute Coronary Syndrome. Dis Markers. 2017;2017:3041565.
  • 6. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17(1):47-58.
  • 7. Estevez-Loureiro R, Salgado-Fernandez J, Marzoa-Rivas R, Barge-Caballero E, Perez-Perez A, Noriega-Concepcion V, et al. Mean platelet volume predicts patency of the infarct-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Thromb Res. 2009;124(5):536-40.
  • 8. Lopez-Cuenca AA, Tello-Montoliu A, Roldan V, Perez-Berbel P, Valdes M, Marin F. Prognostic value of mean platelet volume in patients with non-ST-elevation acute coronary syndrome. Angiology. 2012;63(4):241-4.
  • 9. Dogan A, Aksoy F, Icli A, Arslan A, Varol E, Uysal BA, et al. Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation. Blood Coagul Fibrinolysis. 2012;23(4):324-30.
  • 10. Nardin M, Verdoia M, Barbieri L, De Luca G, Novara Atherosclerosis Study G. Impact of metabolic syndrome on mean platelet volume and its relationship with coronary artery disease. Platelets. 2019;30(5):615-23.
  • 11. Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology. 2011;16(2):86-9.
  • 12. Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications. 2004;18(3):173-6.
  • 13. Zaccardi F, Rocca B, Pitocco D, Tanese L, Rizzi A, Ghirlanda G. Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis. Diabetes Metab Res Rev. 2015;31(4):402-10.
  • 14. Shah B, Sha D, Xie D, Mohler ER, 3rd, Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the National Health And Nutrition Examination Survey, 1999-2004. Diabetes Care. 2012;35(5):1074-8.
  • 15. Verdoia M, Schaffer A, Barbieri L, Cassetti E, Nardin M, Bellomo G, et al. Diabetes, glucose control and mean platelet volume: a single-centre cohort study. Diabetes Res Clin Pract. 2014;104(2):288-94.
  • 16. Hudzik B, Szkodzinski J, Lekston A, Gierlotka M, Polonski L, Gasior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications. 2016;30(6):1097-102.
  • 17. GENSINI C. Coronary arteriography. Heart disease. 1980.
  • 18. Olafsdottir E, Andersson DK, Dedorsson I, Stefansson E. The prevalence of retinopathy in subjects with and without type 2 diabetes mellitus. Acta Ophthalmol. 2014;92(2):133-7.
  • 19. Wang J, Zhang L, Wang F, Liu L, Wang H, China National Survey of Chronic Kidney Disease Working G. Prevalence, awareness, treatment, and control of hypertension in China: results from a national survey. Am J Hypertens. 2014;27(11):1355-61.
  • 20. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2(5):358-67.
  • 21. Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812-23.
  • 22. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK, et al. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians. 2012;4(1):5-9.
  • 23. Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011;128(4):358-60.
  • 24. Tufano A, Cimino E, Di Minno MN, Ierano P, Marrone E, Strazzullo A, et al. Diabetes mellitus and cardiovascular prevention: the role and the limitations of currently available antiplatelet drugs. Int J Vasc Med. 2011;2011:250518.
  • 25. Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014;175(3):433-40.
  • 26. Akin F, Ayca B, Kose N, Altun I, Avsar M, Celik O, et al. Relation of platelet indices to severity of coronary artery disease in patients undergoing primary percutaneous coronary intervention. Perfusion. 2016;31(3):216-22.
  • 27. Borekci A, Gur M, Turkoglu C, Selek S, Baykan AO, Seker T, et al. Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction. Clin Appl Thromb Hemost. 2016;22(2):171-7.
  • 28. Choi DH, Kang SH, Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med. 2016;31(6):1009-17.
  • 29. Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1(2):219-27.
  • 30. XU W-l, XU L, WANG X, SHAO Y-b. Mean platelet volume and its influenced factors in acute coronary syndrome. South China Journal of Cardiovascular Diseases. 2012(1):10.
  • 31. Vogiatzis I, Samaras A, Grigoriadis S, Sdogkos E, Koutsampasopoulos K, Bostanitis I. The Mean Platelet Volume in the Prognosis of Coronary Artery Disease Severity and Risk Stratification of Acute Coronary Syndromes. Med Arch. 2019;73(2):76-80.
  • 32. Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, et al. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis? Int J Clin Exp Med. 2014;7(4):955-61.
  • 33. Sayın MR, Çetiner MA, Karabağ T, Doğan SM, Aydın M, Yavuz N. Koroner Arter Hastalığında Gensini Skoru ve Tam Kan Sayımı Parametreleri Arasındaki İlişki. Koşuyolu Kalp Dergisi.15(2):51-4.
  • 34. Ekici B, Erkan AF, Alhan A, Sayin I, Ayli M, Tore HF. Is mean platelet volume associated with the angiographic severity of coronary artery disease? Kardiol Pol. 2013;71(8):832-8.
  • 35. McKarns SC, Smith CJ, Payne VM, Doolittle DJ. Blood parameters associated with atherogenic and thrombogenic risk in smokers and nonsmokers with similar life-styles. Mod Pathol. 1995;8(4):434-40.
  • 36. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol. 1998;81(4A):7B-12B.

AKUT KORONER SENDROM OLMAYAN TİP 2 DİYABETİK HASTALARDA KORONER ARTER HASTALIĞI YAYGINLIĞI İLE MPV İLİŞKİSİNİN ARAŞTIRILMASI

Year 2021, Volume: 28 Issue: 3, 411 - 417, 13.09.2021
https://doi.org/10.17343/sdutfd.820120

Abstract

Amaç
Birçok çalışma, ortalama trombosit hacmi (MPV) ile
tip 2 diabetes mellitus (T2DM) şiddeti arasındaki ilişkiye
odaklanmakta veya MPV ve koroner arter hastalığı
(KAH) çoğunlukla akut koroner sendrom (AKS)
hastaları üzerinde gerçekleştirilmektedir. Bu çalışma
öncelikle koroner arter hastalığı ve AKS öyküsü olmayan
T2DM hastalarında MPV değerlerinin farklı derecelerdeki
KAH ile ilişkisi araştırılmıştır.
Gereç ve Yöntem
Kasım 2019 ile Şubat 2020 tarihleri arasında ilk koroner
anjiyografi (CAG) yaptıran ve CAG öncesi gece
açlık kan testleri yapılan T2DM hastaları dahil edildi.
Anjiyografiler iki kardiyolog değerlendirdi. Hastalar bu
bulgular ve Gensini skoruna göre; normal koroner arter
(Grup 1), kritik olmayan darlık (Grup II) ve ciddi
KAH (Grup III) olarak 3 gruba ayrıldı. Hastaların demografik
verileri, kalp atış hızı, CAD risk faktörleri ve
MPV dahil kan testleri değerlendirildi.
Bulgular
Çalışmaya toplam 180 hasta (88 kadın, 92 erkek)
dahil edildi. T2DM hastalarında MPV ile KAH şiddeti
arasında anlamlı bir ilişki bulunmadı (p=0,228).
Grup I grubunun ortalama yaşı diğer gruplardan anlamlı
olarak daha düşüktü (p=0,228). Grup I'de diğer
gruplara göre anlamlı oranda düşük sayıda erkek
vardı (p=0,0001). Trigliserid düzeyleri Grup I'de diğer
gruplara göre anlamlı olarak düşüktü (p=0,021 ve
p=0,006).
Sonuç
MPV değerleri stabil hastalarda KAH şiddeti ile ilişkili
bulunmadı. T2DM hastalarında ileri yaş, erkek cinsiyet,
yüksek trigliserit seviyeleri ve başlangıç glikoz seviyeleri,
KAH şiddeti ile önemli ölçüde ilişkiliydi.

References

  • 1. Emerging Risk Factors C, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375(9733):2215-22.
  • 2. Lorber D. Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2014;7:169-83.
  • 3. Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications. 2009;23(2):89-94.
  • 4. Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J. 2008;49(2):114-6.
  • 5. Budzianowski J, Pieszko K, Burchardt P, Rzezniczak J, Hiczkiewicz J. The Role of Hematological Indices in Patients with Acute Coronary Syndrome. Dis Markers. 2017;2017:3041565.
  • 6. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17(1):47-58.
  • 7. Estevez-Loureiro R, Salgado-Fernandez J, Marzoa-Rivas R, Barge-Caballero E, Perez-Perez A, Noriega-Concepcion V, et al. Mean platelet volume predicts patency of the infarct-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Thromb Res. 2009;124(5):536-40.
  • 8. Lopez-Cuenca AA, Tello-Montoliu A, Roldan V, Perez-Berbel P, Valdes M, Marin F. Prognostic value of mean platelet volume in patients with non-ST-elevation acute coronary syndrome. Angiology. 2012;63(4):241-4.
  • 9. Dogan A, Aksoy F, Icli A, Arslan A, Varol E, Uysal BA, et al. Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation. Blood Coagul Fibrinolysis. 2012;23(4):324-30.
  • 10. Nardin M, Verdoia M, Barbieri L, De Luca G, Novara Atherosclerosis Study G. Impact of metabolic syndrome on mean platelet volume and its relationship with coronary artery disease. Platelets. 2019;30(5):615-23.
  • 11. Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology. 2011;16(2):86-9.
  • 12. Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications. 2004;18(3):173-6.
  • 13. Zaccardi F, Rocca B, Pitocco D, Tanese L, Rizzi A, Ghirlanda G. Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis. Diabetes Metab Res Rev. 2015;31(4):402-10.
  • 14. Shah B, Sha D, Xie D, Mohler ER, 3rd, Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the National Health And Nutrition Examination Survey, 1999-2004. Diabetes Care. 2012;35(5):1074-8.
  • 15. Verdoia M, Schaffer A, Barbieri L, Cassetti E, Nardin M, Bellomo G, et al. Diabetes, glucose control and mean platelet volume: a single-centre cohort study. Diabetes Res Clin Pract. 2014;104(2):288-94.
  • 16. Hudzik B, Szkodzinski J, Lekston A, Gierlotka M, Polonski L, Gasior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications. 2016;30(6):1097-102.
  • 17. GENSINI C. Coronary arteriography. Heart disease. 1980.
  • 18. Olafsdottir E, Andersson DK, Dedorsson I, Stefansson E. The prevalence of retinopathy in subjects with and without type 2 diabetes mellitus. Acta Ophthalmol. 2014;92(2):133-7.
  • 19. Wang J, Zhang L, Wang F, Liu L, Wang H, China National Survey of Chronic Kidney Disease Working G. Prevalence, awareness, treatment, and control of hypertension in China: results from a national survey. Am J Hypertens. 2014;27(11):1355-61.
  • 20. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2(5):358-67.
  • 21. Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812-23.
  • 22. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK, et al. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians. 2012;4(1):5-9.
  • 23. Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011;128(4):358-60.
  • 24. Tufano A, Cimino E, Di Minno MN, Ierano P, Marrone E, Strazzullo A, et al. Diabetes mellitus and cardiovascular prevention: the role and the limitations of currently available antiplatelet drugs. Int J Vasc Med. 2011;2011:250518.
  • 25. Sansanayudh N, Anothaisintawee T, Muntham D, McEvoy M, Attia J, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014;175(3):433-40.
  • 26. Akin F, Ayca B, Kose N, Altun I, Avsar M, Celik O, et al. Relation of platelet indices to severity of coronary artery disease in patients undergoing primary percutaneous coronary intervention. Perfusion. 2016;31(3):216-22.
  • 27. Borekci A, Gur M, Turkoglu C, Selek S, Baykan AO, Seker T, et al. Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction. Clin Appl Thromb Hemost. 2016;22(2):171-7.
  • 28. Choi DH, Kang SH, Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med. 2016;31(6):1009-17.
  • 29. Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1(2):219-27.
  • 30. XU W-l, XU L, WANG X, SHAO Y-b. Mean platelet volume and its influenced factors in acute coronary syndrome. South China Journal of Cardiovascular Diseases. 2012(1):10.
  • 31. Vogiatzis I, Samaras A, Grigoriadis S, Sdogkos E, Koutsampasopoulos K, Bostanitis I. The Mean Platelet Volume in the Prognosis of Coronary Artery Disease Severity and Risk Stratification of Acute Coronary Syndromes. Med Arch. 2019;73(2):76-80.
  • 32. Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, et al. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis? Int J Clin Exp Med. 2014;7(4):955-61.
  • 33. Sayın MR, Çetiner MA, Karabağ T, Doğan SM, Aydın M, Yavuz N. Koroner Arter Hastalığında Gensini Skoru ve Tam Kan Sayımı Parametreleri Arasındaki İlişki. Koşuyolu Kalp Dergisi.15(2):51-4.
  • 34. Ekici B, Erkan AF, Alhan A, Sayin I, Ayli M, Tore HF. Is mean platelet volume associated with the angiographic severity of coronary artery disease? Kardiol Pol. 2013;71(8):832-8.
  • 35. McKarns SC, Smith CJ, Payne VM, Doolittle DJ. Blood parameters associated with atherogenic and thrombogenic risk in smokers and nonsmokers with similar life-styles. Mod Pathol. 1995;8(4):434-40.
  • 36. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol. 1998;81(4A):7B-12B.
There are 36 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Ayça Türer Cabbar 0000-0002-3521-2666

Mustafa Aytek Şımşek 0000-0002-3217-4836

Burak Hünük

Olcay Özveren 0000-0003-0436-8964

Özge Güzelburç 0000-0003-3042-9185

Muzaffer Değertekın 0000-0002-5343-692X

Publication Date September 13, 2021
Submission Date November 3, 2020
Acceptance Date March 1, 2021
Published in Issue Year 2021 Volume: 28 Issue: 3

Cite

Vancouver Türer Cabbar A, Şımşek MA, Hünük B, Özveren O, Güzelburç Ö, Değertekın M. EVALUATION OF THE RELATIONSHIP BETWEEN MPV AND SEVERITY OF CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS WITHOUT ACUTE CORONARY SYNDROME. Med J SDU. 2021;28(3):411-7.

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