EVALUATION OF THE RELATIONSHIP BETWEEN MPV AND SEVERITY OF CORONARY ARTERY DISEASE IN TYPE 2 DIABETIC PATIENTS WITHOUT ACUTE CORONARY SYNDROME

Year 2021, Volume: 28 Issue: 3, 411 - 417, 13.09.2021

Ayça Türer Cabbar Mustafa Aytek Şımşek Burak Hünük Olcay Özveren Özge Güzelburç Muzaffer Değertekın

https://doi.org/10.17343/sdutfd.820120

Abstract

Objective
Since many studies focused on the relationship
between mean platelet volume (MPV) and severity of
type 2 diabetes mellitus (T2DM) or investigated MPV
and coronary artery disease (CAD) mostly on acute
coronary syndrome (ACS), this study primarily focused
to investigate if MPV values have any relation with
different levels of CAD specifically in T2DM patients,
who had no previous coronary artery disease, and no
ACS history.
Materials And Methods
T2DM patients who had first coronary angiography
(CAG) between November 2019 and February
2020, and whose after night fasting blood tests
were performed before CAG were included. Two
cardiologists, blinded to the patients, evaluated
angiographies. Patients have divided into groups
accordingly; normal coronary artery (Group 1),
non-critic stenosis (Group II), and severe CAD
(Group III) according to the Gensini score. Patients’
demographics, heart rate, risk factors of CAD, and
blood test including MPV were also collected.
Results
A total of 180 patients (88 female, 92 male) were
involved in the study. There was no significant relation
between MPV and the severity of CAD in T2DM
patients (p=0.228). The mean age of the Group I group
was significantly lower than in other groups (p=0.228),
and there were significantly lower males in Group I
than other groups (p=0.0001). The triglycerides levels
were significantly low in Group I than in other groups
(p=0.021 and p=0.006).
Conclusion
MPV values were not associated with the severity
of CAD in stable patients. Older age, male gender,
higher levels of triglycerides, and initial glucose levels
were significantly related to the severity of CAD in
T2DM patients.

Keywords

Coronary artery disease, mean platelet volume, type 2 diabetes mellitus

AKUT KORONER SENDROM OLMAYAN TİP 2 DİYABETİK HASTALARDA KORONER ARTER HASTALIĞI YAYGINLIĞI İLE MPV İLİŞKİSİNİN ARAŞTIRILMASI

Abstract

Amaç
Birçok çalışma, ortalama trombosit hacmi (MPV) ile
tip 2 diabetes mellitus (T2DM) şiddeti arasındaki ilişkiye
odaklanmakta veya MPV ve koroner arter hastalığı
(KAH) çoğunlukla akut koroner sendrom (AKS)
hastaları üzerinde gerçekleştirilmektedir. Bu çalışma
öncelikle koroner arter hastalığı ve AKS öyküsü olmayan
T2DM hastalarında MPV değerlerinin farklı derecelerdeki
KAH ile ilişkisi araştırılmıştır.
Gereç ve Yöntem
Kasım 2019 ile Şubat 2020 tarihleri arasında ilk koroner
anjiyografi (CAG) yaptıran ve CAG öncesi gece
açlık kan testleri yapılan T2DM hastaları dahil edildi.
Anjiyografiler iki kardiyolog değerlendirdi. Hastalar bu
bulgular ve Gensini skoruna göre; normal koroner arter
(Grup 1), kritik olmayan darlık (Grup II) ve ciddi
KAH (Grup III) olarak 3 gruba ayrıldı. Hastaların demografik
verileri, kalp atış hızı, CAD risk faktörleri ve
MPV dahil kan testleri değerlendirildi.
Bulgular
Çalışmaya toplam 180 hasta (88 kadın, 92 erkek)
dahil edildi. T2DM hastalarında MPV ile KAH şiddeti
arasında anlamlı bir ilişki bulunmadı (p=0,228).
Grup I grubunun ortalama yaşı diğer gruplardan anlamlı
olarak daha düşüktü (p=0,228). Grup I'de diğer
gruplara göre anlamlı oranda düşük sayıda erkek
vardı (p=0,0001). Trigliserid düzeyleri Grup I'de diğer
gruplara göre anlamlı olarak düşüktü (p=0,021 ve
p=0,006).
Sonuç
MPV değerleri stabil hastalarda KAH şiddeti ile ilişkili
bulunmadı. T2DM hastalarında ileri yaş, erkek cinsiyet,
yüksek trigliserit seviyeleri ve başlangıç glikoz seviyeleri,
KAH şiddeti ile önemli ölçüde ilişkiliydi.

Keywords

Koroner arter hastalığı, ortalama trombosit hacmi, tip 2 diabetes mellitus

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