CİLT ROZASEASINDA MEİBOMİAN BEZLERİN DEĞERLENDİRİLMESİ

Year 2021, Volume: 28 Issue: 4, 621 - 626, 30.12.2021

Ersin Muhafiz Seray Aslan Hasan Ali Bayhan Emine Çölgeçen Canan Gürdal

https://doi.org/10.17343/sdutfd.962200

Abstract

Amaç
Cilt rozaseası olan hastalarda gözyaşı fonksiyonlarını
ve Meibomian bezlerin durumunu değerlendirmek.
Gereç ve Yöntem
Cilt rozaseası olan 38 hasta (çalışma grubu) ile 30
sağlıklı gönüllü bireyin (kontrol grubu) sağ gözleri
değerlendirildi. Oküler yüzey hastalık indeksi (OSDI)
skoru hesaplandıktan sonra sırasıyla gözyaşı ozmolariteleri
ve gözyaşı kırılma zamanları (T-BUT) ölçülüp
ve Schirmer testi yapıldı. Alt ve üst kapaktaki meibomian
bezler Sirius ön segment analiz sistemi ile meibografi
yapılarak değerlendirildi.
Bulgular
Gruplar arasında yaş ve cinsiyet açısından istatistiksel
olarak anlamlı fark saptanmadı (p>0.05). OSDI
skoru, gözyaşı ozmolaritesi ve Schirmer değerleri
açısından gruplar arasında istatistiksel olarak anlamlı
fark saptanmadı (tümü için p>0.05). Çalışma grubunun
T-BUT değerlerinin kontrol grubuna göre anlamlı
olarak daha kısa olduğu tespit edildi (p <0.01). Rozasea
ve kontrol grubunda üst göz kapağında meibmian
bezlerdeki kayıp oranının ortanca değerleri sırası ile
%18.00 (çeyrekler arası aralık [ÇAA]: %8.10-27.75)
ve %14.60 (ÇAA: %7.95-25.30) iken alt göz kapağı
meibografisinde bu değerler sırası ile %15.00 (ÇAA:
%9.37-25.90) ve %11.15 (ÇAA: %5.60-19.70) idi.
Hem alt hem de üst göz kapağında meibomian bezlerdeki
kayıp oranı açısından gruplar arasında istatiksel
olarak anlamlı bir fark saptanmadı (sırasıyla,
p=0.39 ve p=0.18).
Sonuç
Cilt rozaseası olan hastalarda daha yüksek oranda
meibomian bez kaybı gözlenmesine rağmen, bu istatistiksel
olarak kontrol grubundan farklı değildi. Buna
rağmen bu hastalarda gözyaşı instabilitesi olduğu
saptandı.

Keywords

Cilt Rozaseası, Gözyaşı Fonksiyonları, Kuru Göz, Meibografi, Meibomian Bezler.

EVALUATION OF MEIBOMIAN GLANDS IN CUTANEOUS ROSACEA

Abstract

Objective
To evaluate tear functions and Meibomian glands’
status in patients with cutaneous rosacea.
Material and Methods
Right eyes of 38 patients with cutaneous rosacea
(study group) and 30 healthy volunteers (control
group) were evaluated. After Ocular Surface Disease
Index (OSDI) score was calculated, tear osmolarity
and tear break-up time (T-BUT) were measured, and
the Schirmer test was applied respectively. Meibomian
glands in the lower and upper eyelids were evaluated
by meibography using the Sirius anterior segment
analysis system.
Results
No statistically significant difference was detected
between the groups in respect of age and gender
(p>0.05). No statistically significant difference was
determined between the groups in respect of the
OSDI score, tear osmolarity, and Schirmer test values
(p>0.05 for all). The T-BUT values of the study group
were detected to be significantly shorter than those
of the control group (p<0.01). The median values
of meibomian gland loss rate in the upper eyelid
of the rosacea and control groups were 18.00%
(Interquartile range [IQR]: 8.10-27.75%) and 14.60%
(IQR: 7.95-25.30%) respectively, while these values
in the lower eyelid meibography, were 15.00% (IQR:
9.37-25.90%) and 11.15% (IQR: 5.60-19.70%)
respectively. No statistically significant difference was
determined between the groups in terms of loss of
meibomian glands in both the upper and lower eyelids
(p=0.39 and p=0.18, respectively).
Conclusion
Although a higher rate of loss of meibomian glands
was observed in patients with cutaneous rosacea, this
was not statistically different from the control group.
However, tear instability was detected in these patients.

Keywords

Cutaneous Rosacea, Tear Functions, Dry Eye, Meibography, Meibomian Glands.

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