EVALUATION OF NEUTROPHIL LYMPHOCYTE RATIO, PLATELET LYMPHOCYTE RATIO AND MEAN PLATELET VOLUME IN MAJOR DEPRESSIVE DISORDER

Year 2022, Volume: 29 Issue: 3, 504 - 509, 30.09.2022

Süleyman Korkut

https://doi.org/10.17343/sdutfd.1146181

Abstract

Objective
The relationship between chronic inflammation and
psychiatric disorders has been evaluated in previous
studies. Neutrophil-lymphocyte ratio (NLR), platelet-
lymphocyte ratio (PLR), and mean platelet volume
(MPV) appear to be new markers for the evaluation of
systemic inflammatory response. In this study, it was
aimed to evaluate the levels of NLR, PLR and MPV
biomarkers in patients with major depressive disorder
(MDD) by comparing them with healthy controls, and
also investigate the relationship between biomarkers
and MDD.
Material and Method
This cross-sectional study was carried out from
July 15, 2020 to May 15, 2021. The study was
conducted with 92 patients with diagnosed MDD and
72 healthy controls who agreed to participate. The
sociodemographic data form and SCID-5/CV form
were filled out for each participant through face-to-face
interviews with all participants. Additionally, Hamilton
Depression Scale was applied to the patient group to
determine the severity of MDB.
Results
Patients with MDD and healthy controls were
compared in terms of the mean scores of NLR, PLR
and MPV, and no statistically significant difference was
found between the groups (p>0.05). Additionally, in
the patient group, there was no statistically significant
difference between the levels of depression severity
(mild, moderate, severe) in terms of the mean scores
of NLR, PLR, and MPV (p>0.05).
Conclusion
This is the first study to evaluate NLR, PLR and
MPV biomarkers simultaneously in MDD patients by
comparing them with healthy controls. In this study,
it was found that there was no significant relationship
between NLR, PLR and MPV levels and MDD.
Additionally, it was determined that there was no
relationship between the severity of depression and the
aforementioned markers. Further studies investigating
these and another biomarkers with prospective
and larger studies will provide more insight into the
inflammatory process in MDD.

Keywords

Major depressive disorder, neutrophil lymphocyte ratio, platelet lymphocyte ratio, mean platelet volume

MAJÖR DEPRESİF BOZUKLUKTA NÖTROFİL LENFOSİT ORANI, TROMBOSİT LENFOSİT ORANI VE ORTALAMA TROMBOSİT HACMİ DEĞERLENDİRİLMESİ

Abstract

Amaç
Kronik inflamasyonun psikiyatrik bozukluklarla ilişkisi
daha önce yapılan çalışmalarda gösterilmiştir. Nötrofil
lenfosit oranı (NLO), platelet lenfosit oranı (PLO) ve
ortalama trombosit hacmi (OTH) sistemik inflamatuar
yanıtın değerlendirilmesinde yeni belirteçler olarak
görülmektedir. Bu kapsamda, bu çalışmanın amacı,
majör depresif bozukluk (MDB) hastalarında NLO,
PLO ve OTH düzeylerinin kontrol grubu ile karşılaştırılarak
değerlendirilmesi, MDB ile bu biyobelirteçler
arasındaki ilişkinin araştırılmasıdır.
Gereç ve Yöntem
Kesitsel tarzda tasarlanan çalışma 15 Temmuz 2020-
15 Mayıs 2021 tarihleri arasında Antalya Eğitim ve
Araştırma Hastanesi Psikiyatri Polikliniğinde yapıldı.
Çalışmaya katılmayı kabul eden 92 MDB hastası
(DSM-5 tanı kriterlerine göre) ve 72 sağlıklı kontrol ile
çalışma yürütüldü. Tüm katılımcılar ile yüzyüze görüşüldü
ve sosyodemografik veri formu dolduruldu. Ayrıca
MDB hastalarına hastalığın şiddetini belirlemek
için Hamilton Depresyon Ölçeği uygulandı.
Bulgular
Gruplar arasında yaş ortalaması ve cinsiyet dağılımı
açısından anlamlı fark yoktu (p>0.05). MDB'li hastalar
ve sağlıklı kontroller NLO, PLO ve OTH puan ortalamaları
açısından karşılaştırıldı ve gruplar arasında
anlamlı farklılık bulunmadı (p>0.05). Ayrıca hasta
grubunda depresyon şiddetine göre (hafif, orta, ciddi)
NLO, PLO ve OTH puan ortalamaları karşılaştırıldı,
istatistiksel olarak anlamlı bir farklılık bulunmadı
(p>0.05).
Sonuç
Bu çalışma, MDB hastalarında NLO, PLO ve OTH biyobelirteçlerini
sağlıklı kontrollerle karşılaştırarak aynı
anda değerlendiren ilk çalışmadır. Çalışmada NLO,
PLO ve OTH düzeyleri ile MDB arasında anlamlı bir
ilişki olmadığı bulunmuştur. Ayrıca depresyon şiddeti
ile bu belirteçler arasında da anlamlı bir ilişki olmadığı
belirlenmiştir. Bunları ve başka biyobelirteçleri konu
alan daha kapsamlı ve daha ileri çalışmalar, MDB'deki
inflamatuar süreç hakkında daha fazla bilgi sağlayacaktır.

Keywords

Majör depresif bozukluk, ortalama trombosit hacmi, nötrofil lenfosit oranı, platelet lenfosit oranı

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