EVALUATION OF IMMUNOHISTOCHEMICAL NEOVASCULAR PSMA AND CD34 EXPRESSIONS IN THYROID TUMORS

Year 2023, Volume: 30 Issue: 1, 79 - 88, 14.03.2023

Mehmet Kıran İbrahim Metin Çiriş

https://doi.org/10.17343/sdutfd.1172871

Abstract

Objective
The aim of this study was to investigate the place
of Prostate Specific Membrane Antigen (PSMA)
expression in differential diagnosis and its effect on
prognosis in thyroid tumors.
Material and Method
Immunohistochemical PSMA and CD34 were applied
to paraffin blocks of 95 patients diagnosed with
different histological types of thyroid cancer. The
percentage of vascular expression in the tumoral and
extratumoral stroma and the density score in the tumor
epithelium were evaluated and grouped according to
PSMA expression level. Final PSMA expression was
determined by multiplying intensity and percentage
points.
An increase in expression was observed with PSMA
in areas with neovascularization in thyroid tumors. No
vascular staining was detected with PSMA in nonneoplastic
thyroid tissue. No increase in expression
was seen in Non-invasive folicular thyroid neoplasm
with papillary like nuclear features (NIFTP) cases
compared to aggressive tumors
Conclusion
It was determined that increased PSMA expression
was associated with poor prognosis, and it was found
that it can be used to differentiate NIFTP cases from
other tumors.

Keywords

Neovascular, PSMA Expression, Thyroid Cancer

TİROİD TÜMÖRLERİNDE İMMÜNOHİSTOKİMYASAL OLARAK NEOVASKÜLER PSMA VE CD34 EKSPRESYONLARININ DEĞERLENDİRİLMESİ

Abstract

Amaç
Bu çalışmanın amacı tiroid tümörlerinde Prostat Spesifik
Membran Antijen (PSMA) ekspresyonunun ayrıcı
tanıdaki yeri ve prognoz üzerine etkisinin araştırılmasıdır.
Gereç ve Yöntem
Farklı histolojik tipteki 95 tiroid kanseri tanısı alan hastaların
parafin bloklarına immünohistokimyasal PSMA
ve CD34 uygulandı. Tümöral ve ekstratümoral stromadaki
vasküler ekspresyon yüzdesi ve tümör epitelindeki
yoğunluk skoru değerlendirildi ve PSMA ekspresyon
düzeyine göre gruplara ayrıldı. Nihai PSMA
ifadesi, yoğunluk ve yüzde puanları çarpılarak belirlendi.
Bulgular
Tiroid tümörlerinde yeni damar oluşumu olan alanlarda
PSMA ile ekspresyon artışı izlendi. Non-neoplastik
tiroid dokusunda PSMA ile vasküler boyanma saptanmadı.
Papiller Benzeri Nükleer Özellikler Gösteren
Noninvaziv Foliküler Neoplazi (NİFTP) vakalarında
agresif tümörlere göre karşılaştırıldığında ekspresyon
artışı görülmedi
Sonuç
PSMA ekspresyon artışının kötü prognozla ilişkili olduğu
saptandı ve NİFTP vakalarının diğer tümörler ile
ayrımında kullanılabileceği yönünde bulgular saptandı

Keywords

Neovaskülarizasyon, PSMA ekspresyonu, Tiroid Karsinomu

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