Chronic Obstructive Pulmonary Disease (COPD) and Magnesium Levels: Relationship Analysis

Year 2025, Volume: 32 Issue: 1, 81 - 87, 27.03.2025

İmren Mutlu Hayat , Faruk Günak

Abstract

Objective: Identifying modifiable risk factors is very important for preventing acute chronic obstructive pulmonary disease (COPD) severity. This study was conducted to determine the role of serum magnesium levels in acute COPD exacerbation.
Material and Method: A total of 104 COPD patients with a mean age of 66.63 ± 8.79 years and female 17.3%(18) males 82.69%(86) were included in our study. Chest X-ray, respiratory function test, and biochemical blood tests were performed on the cases. The relationship between magnesium level and COPD severity was evaluated using appropriate statistical methods.
Results: Demographic data of the patients were collected, biochemical evaluation was performed, and the relationship between magnesium levels and respiratory parameters was investigated. Serum magnesium was found to be low in patients (25%). COPD evaluation test was compared with mMMR and CAT, dyspnea symptoms were observed to be more in hypomagnesemia cases, and the difference was found to be statistically significant (p:0.029, p:0.030, respectively). In terms of respiratory function tests, FEF25-75 was found to be lower and statistically significant in hypomagnesemia patients. Disease duration was found to be statistically significant in hypomagnesemia cases (p:0.033). When compared with male and female patients, smoking was observed more in male individuals, and this parameter was also found to be statistically significant (p:0.044).
Conclusion: It was concluded that hypomagnesemia may increase respiratory distress in COPD patients and contribute to COPD exacerbations.

Keywords

Chronic Obstruktive Pulmonary Disease, Magnesium, Pulmonary Funtion Tests

Ethical Statement

Ethics Committee approval for this study was obtained from Harran University, as evidenced by a letter dated 12.12.2022- HRÜ/22.24.28. This study was conducted in accordance with the principles outlined in the Declaration of Helsinki.

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