Restoratif Diş Hekimliğinde Çürük Önleme ve Tedavilerinde Nanoteknoloji Stratejileri

Year 2023, , 492 - 496, 21.08.2023

Cemile Yılmaz

https://doi.org/10.15311/selcukdentj.1169549

Abstract

Diş çürüğü en sık görülen ağız hastalığıdır. Diş çürüklerinin bakteriyolojik etiyolojisi, bu tür oral bulaşıcı hastalıkları önlemek için antibiyotik veya antimikrobiyal ajanların kullanımını teşvik eder. Sistemik antibiyotikler diş çürüklerini tedavi etmek için uzun süredir kullanılmaktadır. Bununla birlikte, diş çürüklerine karşı savaşmak için yeni antimikrobiyal ajanlar geliştirilmiştir. Nanoteknoloji, nanomalzemelerin kullanımı yoluyla tıp da dahil olmak üzere çeşitli alanlarda birçok heyecan verici ve yeni uygulamalar ortaya çıkmasını sağlamıştır. Nanopartiküllerin kullanımı artık diş enfeksiyonları ve hastalıklarının tedavisi ve önlenmesi için düşünülmektedir. Bu nanomalzemeler, diş çürükleri de dahil olmak üzere ağız hastalıklarını önlemek ve tedavi etmek için restoratif, protetik, endodonti, periodontal tedaviler ve implantasyonlarda kullanılan rezinler, metaller, seramikler vb. gibi malzemelere dahil edilebilir. Nanoteknoloji diş çürüklerini iki ana yaklaşımda tedavi eder. Diş çürüğü yönetimi için nanoteknoloji tabanlı stratejiler remineralize yaklaşım ve antibakteriyel yaklaşımdır. İlk yaklaşımda, kalsiyum fosfat, kalsiyum florür, hidroksiapatit ve florohidroksiapapit gibi florür ve kalsiyum salınım kabiliyetine sahip nanomalzemeler remineralizasyon adı verilen bir süreçte kullanılmaktadır. Gümüş, kuaterner amonyum polietilenimin ve çinko oksit nanopartikülleri gibi antibakteriyel nanomalzemelerin uygulanması ikinci yaklaşımdır. Bu iki yaklaşımın bir kombinasyonu daha iyi sonuçlar sunmak için de kullanılabilir. Bu derlemenin amacı, diş çürüklerinin gelişimini durdurmak ve önlemek amacıyla, oral patojenlerle mücadelede nanoteknoloji ile yeni ve geliştirilmiş dental ajanların kullanım, etki mekanizmaları hakkında en güncel bilgileri bir arada toplamaktır.

Keywords

Diş Çürükleri, İlaç Dağıtım Sistemleri, Koruyucu Diş Hekimliği, Nanoteknoloji

Nanotechnology Strategies for Caries Prevention and Treatment in Restorative Dentistry

Abstract

Tooth decay is the most common oral disease. The bacteriological etiology of dental caries encourages the use of antibiotics or antimicrobial agents to prevent such oral infectious diseases. Systemic antibiotics have long been used to treat dental caries. However, new antimicrobial agents have been developed to combat dental caries. Nanotechnology has provided many exciting and new applications in various fields, including medicine, through the use of nanomaterials. The use of nanoparticles is now considered for the treatment and prevention of dental infections and diseases. These nanomaterials are used in restorative, prosthetic, endodontic, periodontal treatments and implants such as resins, metals, ceramics etc. to prevent and treat oral diseases including dental caries. may be included in materials such as Nanotechnology treats dental caries in two main approaches. Nanotechnology-based strategies for dental caries management are the remineralized approach and the antibacterial approach. In the first approach, nanomaterials capable of releasing calcium fluoride and calcium such as calcium phosphate, calcium fluoride, hydroxyapatite and fluorohydroxyapapite are used in a process called remineralization. Application of antibacterial nanomaterials such as silver, quaternary ammonium polyethyleneimine and zinc oxide nanoparticles is the second approach. A combination of these two approaches can also be used to deliver better results. The aim of this review is to gather the most up-to-date information on the use and mechanisms of action of new and improved dental agents, with nanotechnology in the fight against oral pathogens, in order to stop and prevent the development of dental caries.

Keywords

Dental Caries, Drug Delivery Systems, Nanotechnology, Preventive Dentistry

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