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Tam Protezlerin Güncel Üretim Teknikleri: Geleneksel Derleme

Year 2023, , 605 - 610, 25.12.2023
https://doi.org/10.15311/selcukdentj.1238453

Abstract

Tam protezler günümüzde hala sıklıkla kullanılan hareketli protezlerdendir. Hareketli tam protezlerin üretimi için geleneksel yaklaşımın bazı dezavantajları bulunmaktadır. Çok sayıda klinik ve laboratuvar aşamasının bulunması, zaman alıcı olması ve yoğun emek sarf edilmesinin gerekmesi bunlardan birkaçıdır. Ayrıca tüm bu klinik ve laboratuvar aşamalarının manuel olarak gerçekleştirildiği göz önüne alınırsa hazırlanan protezlerde optimal kaliteyi sağlamak oldukça zordur. Tam protezlerde kaide materyali olarak en çok tercih edilen akrilik rezin, polimetil metaakrilattır. Bu rezinin kolay onarımı ve maliyetinin düşük olması gibi avantajları olmasına rağmen polimerizasyon büzülmesine bağlı olarak ortaya çıkan boyutsal değişimi ise en büyük dezavantajıdır. Bu deformasyonlardan kaçınmak için birçok muflalama tekniği geliştirilmiş olsa da istenilen düzeyde bir başarı sağlanamamış olması araştırmacıları başka teknik arayışlarına yönlendirmiş ve bu yüzden tam protezlerin yapımında daha fazla tekniğin optimizasyonunun klinik pratiğe fayda sağlayacağı düşünülmüştür. Dijital diş hekimliğindeki güncel gelişmeler tam protez tedavi yöntemlerini ve üretimlerini etkilemeye başlamıştır. Modern teknolojinin tam protezlerin üretimine olan entegrasyonuyla fabrikasyon prosedürlerinde farklılıklar ortaya çıkmıştır. Dijital iş akışı için yayınlarda önerilen adımlar oldukça çeşitlilik göstermektedir. Yeni teknolojiler hem hekimler hem de teknisyenler için özel bilgi ve beceriler gerektirirken, vasıflı el işçiliğine olan ihtiyacı ise azaltmıştır. Bu derlemenin amacı tam protezlerin geleneksel ve dijital tekniklerle üretimi ile ilgili mevcut literatürü pekiştirmek, klinik ve laboratuvar aşamalarının mevcut dijital iş akışlarını özetlemek, dijital alternatiflerin aşamalarını açıklamak ve bunların avantajlarını ve sınırlamalarını tartışmaktır.

References

  • 1. Aerden D. Türk Diş Hekimleri Birliği Dergisi 2006;9:4.
  • 2. AI Jabbari Y, Nagy WW. Implant Dentistry for Geriatric Patients: A Review of The Literature. Quintessence International 2003;34.
  • 3. Cunha T, Della Vecchia M, Regis R, Ribeiro A, Muglia V, Mestriner Jr W, et al. A Randomised Trial on Simplified and Conventional Methods for Complete Denture Fabrication: Masticatory Performance and Ability. Journal of Dentistry 2013;41:133-42.
  • 4. Vecchia MPD, Regis RR, Cunha TR, de Andrade IM, da Matta JCS, de Souza RF. A Randomized Trial on Simplified and Conventional Methods for Complete Denture Fabrication: Cost Analysis. Journal of Prosthodontics 2014;23:182-91.
  • 5. Walls A, Steele J. The Relationship Between Oral Health and Nutrition in Older People. Mechanisms of Ageing and Development 2004;125:853-7.
  • 6. Doğan BG, Gökalp S. Tooth Loss and Edentulism in the Turkish Elderly. Arch Gerontol Geriatr 2012;54:e162-6.
  • 7. Çalıkkocaoğlu S. Dişsiz Hastaların Protetik Tedavisi: Klasik Tam Protezler. İstanbul: Quintessence Yayıncılık, 2010. p. 62-437
  • 8. Rotim Ž, Pelivan I, Sabol I, Sušić M, Ćatić A, Bošnjak AP. The Effect of Local and Systemic Factors on Dental Implant Failure - Analysis of 670 Patients with 1260 Implants. Acta Clin Croat 2022;60:367-72.
  • 9. The Glossary of Prosthodontic Terms: Ninth Edition. J Prosthet Dent, 2017;117:e1-e105.
  • 10. 10. Nazlıel HÇ. Yaşlıda Ağız ve Diş Sağlığı. Turkish Journal of Geriatrics. 1999;2:14-21.
  • 11. Han W, Li Y, Zhang Y, Zhang Y, Hu P, Liu H, et al. Design and Fabrication of Complete Dentures Using CAD/CAM Technology. Medicine 2017;96-1.
  • 12. McCabe JF, Walls AW. Applied Dental Materials. Sussex: John Wiley & Sons, 2013.
  • 13. Gharechahi J, Asadzadeh N, Shahabian F, Gharechahi M. Dimensional Changes of Acrylic Resin Denture Bases: Conventional Versus Injection-molding Technique. Journal of Dentistry 2014;11:398.
  • 14. Zarb GA, Hobkirk J, Eckert S, Jacob R. Prosthodontic Treatment for Edentulous Patients: Complete Dentures and Implant-supported Prostheses. Elsevier Health Sciences 2013.
  • 15. Keenan PL, Radford DR, Clark RK. Dimensional Change in Complete Dentures Fabricated by Injection Molding and Microwave Processing. The Journal of Prosthetic Dentistry 2003;89:37-44.
  • 16. Çalıkkocaoğlu S. Tam Protezler: Cilt 1. Ankara: Protez Akademisi ve Gnatoloji Derneği 2 Bilimsel Yayını, 2004.
  • 17. Woelfel JB, Paffenbarger GC, Sweeney WT. Dimensional Changes Occurring in Dentures During Processing. The Journal of the American Dental Association 1960;61:413-30.
  • 18. Meloto CB, Neves ACC, Cunha LG, Rizzatti-Barbosa CM. Influence of Different Flasking and Polymerizing Methods on The Occlusal Vertical Dimension of Complete Dentures. Acta Odontologica Latinoamericana 2012;25:312-7.
  • 19. Shibayama R, Filho HG, Mazaro JVQ, Vedovatto E, Assunção WG. Effect of Flasking and Polymerization Techniques on Tooth Movement in Complete Denture Processing. Journal of Prosthodontics: Implant, Esthetic and Reconstructive Dentistry 2009;18:259-64.
  • 20. Goodacre BJ, Goodacre CJ, Baba NZ, Kattadiyil MT. Comparison of Denture Base Adaptation Between CAD-CAM and Conventional Fabrication Techniques. The Journal of Prosthetic Dentistry 2016;116:249-56.
  • 21. Ulusoy M, AK A. Diş Hekimliğinde Hareketli Bölümlü Protezler: Cilt 2. Ankara: Ankara Üniversitesi Basımevi, 2003:687-9.
  • 22. Anusavice KJ, Shen C, Rawls HR. Phillips' Science of Dental Materials: Elsevier Health Sciences, 2012.
  • 23. Açıkgöz O. Dişhekimliğinde Maddeler Bilgisi. Edebiyat Fakültesi Ofset Tesisleri. 1996;227.
  • 24. O'brien WJ. Dental Materials and Their Selection, Quintessence 2002.
  • 25. Kalipcilar B, Karaagaclioglu L, Hasanreisoglu U. Evaluation of The Level of Residual Monomer in Acrylic Denture Base Materials Having Different Polymerization Properties. Journal of Oral Rehabilitation 1991;18:399-401.
  • 26. Lee H-J, Kim C-W, Kim Y-S. The Level of Residual Monomer in Injection Molded Denture Base Materials. The Journal of Korean Academy of Prosthodontics 2003;41:360-8.
  • 27. Sofou A, Emmanouil J, Peutzfeldt A, Owall B. The Effect of Different Polishing Techniques on The Surface Roughness of Acrylic Resin Materials. The European Journal of Prosthodontics and Restorative Dentistry 2001;9:117-22.
  • 28. O’Donnell EF, Radford DR, Sinclair GF, Clark R. Chairside Polishing of Heat-cured Acrylic Resin: an SEM and EDA Study. Journal of Prosthetic Dentistry 2003;90:585.
  • 29. Bural C, AktaŞ E, Deniz G, Ünlüçerçi Y, Bayraktar G. Effect of Leaching Residual Methyl methacrylate Concentrations on in vitro Cytotoxicity of Heat Polymerized Denture Base Acrylic Resin Processed with Different Polymerization Cycles. Journal of Applied Oral Science 2011;19:306-12.
  • 30. Berdicevsky I, Ben-Aryeh H, Szargel R, Gutman D. Oral Candida in Asymptomatic Denture Wearers. International Journal of Oral Surgery 1980;9:113-5.
  • 31. Budtz‐Jörgensen E. The Significance of Candida Albicans in Denture Stomatitis. European Journal of Oral Sciences 1974;82:151-90.
  • 32. Rickman LJ, Padipatvuthikul P, Satterthwaite JD. Contemporary Denture Base Resins: Part 1. Dental Update 2012;39:25-30.
  • 33. Rickman LJ, Padipatvuthikul P, Satterthwaite JD. Contemporary Denture Base resins: Part 2. Dental Update 2012;39:176-87.
  • 34. Paulino MR, Alves LR, Gurgel BC, Calderon PS. Simplified versus Traditional Techniques for Complete Denture Fabrication: A Systematic Review. The Journal of Prosthetic Dentistry 2015;113:12-6.
  • 35. Anadioti E, Musharbash L, Blatz MB, Papavasiliou G, Kamposiora P. 3D printed Complete Removable Dental Prostheses: A Narrative Review. BMC Oral Health 2020;20:1-9.
  • 36. Beuer F, Schweiger J, Edelhoff D. Digital Dentistry: An Overview of Recent Developments for CAD/CAM Generated Restorations. British Dental Journal 2008;204:505-11.
  • 37. Hazeveld A, Slater JJH, Ren Y. Accuracy and Reproducibility of Dental Replica Models Reconstructed by Different Rapid Prototyping Techniques. American Journal of Orthodontics and Dentofacial Orthopedics 2014;145:108-15.
  • 38. Brkić B, France N, Clare AT, Sutcliffe CJ, Chalker PR, Taylor S. Development of Quadrupole Mass Spectrometers Using Rapid Prototyping Technology. Journal of The American Society for Mass Spectrometry 2009;20:1359-65.
  • 39. Steinmassl P-A, Klaunzer F, Steinmassl O, Dumfahrt H, Grunert I. Evaluation of Currently Available CAD/CAM Denture Systems. Int J Prosthodont 2017;30:116-22.
  • 40. Kattadiyil MT, Goodacre CJ, Baba NZ. CAD/CAM Complete Dentures: A Review of Two Commercial Fabrication Systems. Journal of the California Dental Association 2013;41:407-16.
  • 41. AvaDent Digital Dental Solutions [Erişim tarihi:16 Ocak 2023] Erişim linki: https://www.avadent.com/record-methods.
  • 42. Baba NZ, Goodacre BJ, Goodacre CJ, Müller F, Wagner S. CAD/CAM Complete Denture Systems and Physical Properties: A Review of the Literature. Journal of Prosthodontics 2021;30:113-24.
  • 43. Baltic Denture System: Innovation Merz Dental GmbH [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.baltic-denture-system.de/en/practice/.
  • 44. VITA Zahnfabrik H. Rauter GmbH & Co.KG [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.vita-zahnfabrik.com/en/Chapter-28410,,204078.html?kapitel_id=204079.
  • 45. Amann Girrbach AG © 2006 - 2023 [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.amanngirrbach.com/en/products/ceramill-fds/.
  • 46. DENTCA, Inc. © 2016 [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://dentca.com/blog/home/products/dentca-3d-printed-dentures.
  • 47. Dentsply Sirona© 2023 [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.dentsplysirona.com/en-us/discover/discover-by-category/dental-lab/digital-dentures.html.
  • 48. Lo Russo L, Zhurakivska K, Guida L, Chochlidakis K, Troiano G, Ercoli C. Comparative Cost-analysis for Removable Complete Dentures Fabricated with Conventional, Partial and Complete Digital Workflows. J Prosthet Dent 2022.
  • 49. Bilgin MS, Baytaroğlu EN, Erdem A, Dilber E. A Review of Computer-aided Design/Computer-aided Manufacture Techniques for Removable Denture Fabrication. Eur J Dent 2016;10:286-91.

Current Manufacturıng Techniques Of Complete Dentures: Traditional Review

Year 2023, , 605 - 610, 25.12.2023
https://doi.org/10.15311/selcukdentj.1238453

Abstract

Complete dentures are still frequently used removable dentures. The traditional approach for the manufacture of removable complete dentures has some disadvantages. There are many clinical and laboratory stages, it is time consuming, and it requires intensive effort, to name a few. In addition, considering that all these clinical and laboratory stages are carried out manually, it is very difficult to ensure optimal quality in the prepared prostheses. Acrylic resin polymethyl methacrylate is the most preferred base material in complete dentures. Although this resin has advantages such as easy repair and low cost, its dimensional change due to polymerization shrinkage is its biggest disadvantage. Although many muffle techniques have been developed to avoid these deformations, the lack of success at the desired level has led the researchers to search for other techniques, and therefore, it was thought that more technical optimization in the construction of complete dentures would benefit clinical practice. Current developments in digital dentistry have begun to affect complete denture treatment methods and production. With the integration of modern technology into the production of complete dentures, differences in fabrication procedures have emerged. The steps suggested in publications for a digital workflow vary widely. While new technologies require special knowledge and skills for both physicians and technicians, they have reduced the need for skilled craftsmanship. The purpose of this review is to consolidate the existing literature on the fabrication of complete dentures with traditional and digital techniques, to summarize the current digital workflows of the clinical and laboratory stages, to explain the stages of digital alternatives, and to discuss their advantages and limitations.

References

  • 1. Aerden D. Türk Diş Hekimleri Birliği Dergisi 2006;9:4.
  • 2. AI Jabbari Y, Nagy WW. Implant Dentistry for Geriatric Patients: A Review of The Literature. Quintessence International 2003;34.
  • 3. Cunha T, Della Vecchia M, Regis R, Ribeiro A, Muglia V, Mestriner Jr W, et al. A Randomised Trial on Simplified and Conventional Methods for Complete Denture Fabrication: Masticatory Performance and Ability. Journal of Dentistry 2013;41:133-42.
  • 4. Vecchia MPD, Regis RR, Cunha TR, de Andrade IM, da Matta JCS, de Souza RF. A Randomized Trial on Simplified and Conventional Methods for Complete Denture Fabrication: Cost Analysis. Journal of Prosthodontics 2014;23:182-91.
  • 5. Walls A, Steele J. The Relationship Between Oral Health and Nutrition in Older People. Mechanisms of Ageing and Development 2004;125:853-7.
  • 6. Doğan BG, Gökalp S. Tooth Loss and Edentulism in the Turkish Elderly. Arch Gerontol Geriatr 2012;54:e162-6.
  • 7. Çalıkkocaoğlu S. Dişsiz Hastaların Protetik Tedavisi: Klasik Tam Protezler. İstanbul: Quintessence Yayıncılık, 2010. p. 62-437
  • 8. Rotim Ž, Pelivan I, Sabol I, Sušić M, Ćatić A, Bošnjak AP. The Effect of Local and Systemic Factors on Dental Implant Failure - Analysis of 670 Patients with 1260 Implants. Acta Clin Croat 2022;60:367-72.
  • 9. The Glossary of Prosthodontic Terms: Ninth Edition. J Prosthet Dent, 2017;117:e1-e105.
  • 10. 10. Nazlıel HÇ. Yaşlıda Ağız ve Diş Sağlığı. Turkish Journal of Geriatrics. 1999;2:14-21.
  • 11. Han W, Li Y, Zhang Y, Zhang Y, Hu P, Liu H, et al. Design and Fabrication of Complete Dentures Using CAD/CAM Technology. Medicine 2017;96-1.
  • 12. McCabe JF, Walls AW. Applied Dental Materials. Sussex: John Wiley & Sons, 2013.
  • 13. Gharechahi J, Asadzadeh N, Shahabian F, Gharechahi M. Dimensional Changes of Acrylic Resin Denture Bases: Conventional Versus Injection-molding Technique. Journal of Dentistry 2014;11:398.
  • 14. Zarb GA, Hobkirk J, Eckert S, Jacob R. Prosthodontic Treatment for Edentulous Patients: Complete Dentures and Implant-supported Prostheses. Elsevier Health Sciences 2013.
  • 15. Keenan PL, Radford DR, Clark RK. Dimensional Change in Complete Dentures Fabricated by Injection Molding and Microwave Processing. The Journal of Prosthetic Dentistry 2003;89:37-44.
  • 16. Çalıkkocaoğlu S. Tam Protezler: Cilt 1. Ankara: Protez Akademisi ve Gnatoloji Derneği 2 Bilimsel Yayını, 2004.
  • 17. Woelfel JB, Paffenbarger GC, Sweeney WT. Dimensional Changes Occurring in Dentures During Processing. The Journal of the American Dental Association 1960;61:413-30.
  • 18. Meloto CB, Neves ACC, Cunha LG, Rizzatti-Barbosa CM. Influence of Different Flasking and Polymerizing Methods on The Occlusal Vertical Dimension of Complete Dentures. Acta Odontologica Latinoamericana 2012;25:312-7.
  • 19. Shibayama R, Filho HG, Mazaro JVQ, Vedovatto E, Assunção WG. Effect of Flasking and Polymerization Techniques on Tooth Movement in Complete Denture Processing. Journal of Prosthodontics: Implant, Esthetic and Reconstructive Dentistry 2009;18:259-64.
  • 20. Goodacre BJ, Goodacre CJ, Baba NZ, Kattadiyil MT. Comparison of Denture Base Adaptation Between CAD-CAM and Conventional Fabrication Techniques. The Journal of Prosthetic Dentistry 2016;116:249-56.
  • 21. Ulusoy M, AK A. Diş Hekimliğinde Hareketli Bölümlü Protezler: Cilt 2. Ankara: Ankara Üniversitesi Basımevi, 2003:687-9.
  • 22. Anusavice KJ, Shen C, Rawls HR. Phillips' Science of Dental Materials: Elsevier Health Sciences, 2012.
  • 23. Açıkgöz O. Dişhekimliğinde Maddeler Bilgisi. Edebiyat Fakültesi Ofset Tesisleri. 1996;227.
  • 24. O'brien WJ. Dental Materials and Their Selection, Quintessence 2002.
  • 25. Kalipcilar B, Karaagaclioglu L, Hasanreisoglu U. Evaluation of The Level of Residual Monomer in Acrylic Denture Base Materials Having Different Polymerization Properties. Journal of Oral Rehabilitation 1991;18:399-401.
  • 26. Lee H-J, Kim C-W, Kim Y-S. The Level of Residual Monomer in Injection Molded Denture Base Materials. The Journal of Korean Academy of Prosthodontics 2003;41:360-8.
  • 27. Sofou A, Emmanouil J, Peutzfeldt A, Owall B. The Effect of Different Polishing Techniques on The Surface Roughness of Acrylic Resin Materials. The European Journal of Prosthodontics and Restorative Dentistry 2001;9:117-22.
  • 28. O’Donnell EF, Radford DR, Sinclair GF, Clark R. Chairside Polishing of Heat-cured Acrylic Resin: an SEM and EDA Study. Journal of Prosthetic Dentistry 2003;90:585.
  • 29. Bural C, AktaŞ E, Deniz G, Ünlüçerçi Y, Bayraktar G. Effect of Leaching Residual Methyl methacrylate Concentrations on in vitro Cytotoxicity of Heat Polymerized Denture Base Acrylic Resin Processed with Different Polymerization Cycles. Journal of Applied Oral Science 2011;19:306-12.
  • 30. Berdicevsky I, Ben-Aryeh H, Szargel R, Gutman D. Oral Candida in Asymptomatic Denture Wearers. International Journal of Oral Surgery 1980;9:113-5.
  • 31. Budtz‐Jörgensen E. The Significance of Candida Albicans in Denture Stomatitis. European Journal of Oral Sciences 1974;82:151-90.
  • 32. Rickman LJ, Padipatvuthikul P, Satterthwaite JD. Contemporary Denture Base Resins: Part 1. Dental Update 2012;39:25-30.
  • 33. Rickman LJ, Padipatvuthikul P, Satterthwaite JD. Contemporary Denture Base resins: Part 2. Dental Update 2012;39:176-87.
  • 34. Paulino MR, Alves LR, Gurgel BC, Calderon PS. Simplified versus Traditional Techniques for Complete Denture Fabrication: A Systematic Review. The Journal of Prosthetic Dentistry 2015;113:12-6.
  • 35. Anadioti E, Musharbash L, Blatz MB, Papavasiliou G, Kamposiora P. 3D printed Complete Removable Dental Prostheses: A Narrative Review. BMC Oral Health 2020;20:1-9.
  • 36. Beuer F, Schweiger J, Edelhoff D. Digital Dentistry: An Overview of Recent Developments for CAD/CAM Generated Restorations. British Dental Journal 2008;204:505-11.
  • 37. Hazeveld A, Slater JJH, Ren Y. Accuracy and Reproducibility of Dental Replica Models Reconstructed by Different Rapid Prototyping Techniques. American Journal of Orthodontics and Dentofacial Orthopedics 2014;145:108-15.
  • 38. Brkić B, France N, Clare AT, Sutcliffe CJ, Chalker PR, Taylor S. Development of Quadrupole Mass Spectrometers Using Rapid Prototyping Technology. Journal of The American Society for Mass Spectrometry 2009;20:1359-65.
  • 39. Steinmassl P-A, Klaunzer F, Steinmassl O, Dumfahrt H, Grunert I. Evaluation of Currently Available CAD/CAM Denture Systems. Int J Prosthodont 2017;30:116-22.
  • 40. Kattadiyil MT, Goodacre CJ, Baba NZ. CAD/CAM Complete Dentures: A Review of Two Commercial Fabrication Systems. Journal of the California Dental Association 2013;41:407-16.
  • 41. AvaDent Digital Dental Solutions [Erişim tarihi:16 Ocak 2023] Erişim linki: https://www.avadent.com/record-methods.
  • 42. Baba NZ, Goodacre BJ, Goodacre CJ, Müller F, Wagner S. CAD/CAM Complete Denture Systems and Physical Properties: A Review of the Literature. Journal of Prosthodontics 2021;30:113-24.
  • 43. Baltic Denture System: Innovation Merz Dental GmbH [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.baltic-denture-system.de/en/practice/.
  • 44. VITA Zahnfabrik H. Rauter GmbH & Co.KG [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.vita-zahnfabrik.com/en/Chapter-28410,,204078.html?kapitel_id=204079.
  • 45. Amann Girrbach AG © 2006 - 2023 [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.amanngirrbach.com/en/products/ceramill-fds/.
  • 46. DENTCA, Inc. © 2016 [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://dentca.com/blog/home/products/dentca-3d-printed-dentures.
  • 47. Dentsply Sirona© 2023 [Erişim tarihi: 16 Ocak 2023] Erişim linki: https://www.dentsplysirona.com/en-us/discover/discover-by-category/dental-lab/digital-dentures.html.
  • 48. Lo Russo L, Zhurakivska K, Guida L, Chochlidakis K, Troiano G, Ercoli C. Comparative Cost-analysis for Removable Complete Dentures Fabricated with Conventional, Partial and Complete Digital Workflows. J Prosthet Dent 2022.
  • 49. Bilgin MS, Baytaroğlu EN, Erdem A, Dilber E. A Review of Computer-aided Design/Computer-aided Manufacture Techniques for Removable Denture Fabrication. Eur J Dent 2016;10:286-91.
There are 49 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Review
Authors

Ayşe Hançer Göymen 0000-0002-1956-4055

Mustafa Kocacıklı 0000-0002-2417-588X

A.dilek Nalbant 0000-0002-0554-5208

Publication Date December 25, 2023
Submission Date January 18, 2023
Published in Issue Year 2023

Cite

Vancouver Hançer Göymen A, Kocacıklı M, Nalbant A. Tam Protezlerin Güncel Üretim Teknikleri: Geleneksel Derleme. Selcuk Dent J. 2023;10(3):605-10.