Mineral Trioksit Agregat: Bir Literatür Derlemesi

Year 2022, , 959 - 967, 26.12.2022

Merve Abaklı İnci , Hazal Özer , Ümran Keskin

https://doi.org/10.15311/selcukdentj.956025

Abstract

Mineral trioksit agregat (MTA), esas olarak kalsiyum ve silikat elementlerinden oluşan biyoaktif endodontik bir simandır. 1990' larda Torabinejad tarafından tanıtılmış, 1997' de ise Amerika Birleşik Devletleri'nde kullanılmak üzere Gıda ve İlaç İdaresi (FDA) tarafından onaylanmıştır. MTA; sement gelişimine olanak tanıyan ve periodontal ligament hücrelerinde rejenerasyon sağlayan ilk restoratif materyaldir. Biyouyumlu bir materyal olan MTA, düşük sitotoksisiteye sahiptir. Apeks dışına taştığı durumlarda minimal inflamasyona neden olur. Odontoblastik tabaka oluşumu sayesinde dentin köprüsü oluşumunu indükler. Pulpal fibroblastlardan sitokin salınımını uyarır, bu da sert doku oluşumunu stimüle ederek hücrelerin hızlı büyümesini destekler. İlk olarak retrograd dolgu materyali olarak kullanılmaya başlayan MTA; daha sonra pulpa kuafaj tedavileri, iatrojenik ve furkasyon perforasyonlarının tamiri, retine süt dişlerinin kök kanal tedavisi, apeksifikasyon sırasında bariyer oluşturulması, devital beyazlatmada bariyer gibi çeşitli klinik uygulamalarda da kullanım alanı bulmuştur. MTA’ nın biyouyumluluk, sızdırmazlık, pulpa ve periradiküler dokuların rejenerasyonunu artırma kapasitesi gibi özellikleri; dental kullanım alanlarındaki çeşitliliği ve klinik başarı oranlarını artmasını sağlamış ve bu yenilikçi yapısıyla klinisyenlerin ilgi odağı haline gelmiştir. Dişte renk değişikliğine sebep olması ve sertleşme süresindeki değişiklikler başlıca dezavantajlarıdır. Yapılan in vitro çalışmalar başarılı sonuçlar vermiş olsa da; uzun dönem başarısının desteklenmesi amacıyla kontrollü klinik çalışmalara ihtiyaç duyulmaktadır.
Bu literatür derlemesinde, MTA’ nın fiziksel, kimyasal, biyolojik ve antimikrobiyal özellikleri, klinik uygulama şekilleri ve güncel formülasyonları sunulmaktadır.

Keywords

biyouyumlu materyaller, kalsiyum hidroksit, mineral trioksid agregat, rejenerasyon

References

• Parirokh M, Torabinejad M, Dummer PMH. Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview–part I: vital pulp therapy. International endodontic journal. 2018; 51(2): 177-205.
• Torabinejad M, Parirokh M, Dummer PMH. Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview–part II: other clinical applications and complications. International endodontic journal. 2018; 51(3): 284-317.
• O'Sullivan SM, Hartwell GR. Obturation of a retained primary mandibular second molar using mineral trioxide aggregate: a case report. Journal of endodontics. 2001; 27(11): 703-705.
• Hsien HC, Cheng YA, Lee YL, Lan WH, & Lin CP. Repair of perforating internal resorption with mineral trioxide aggregate: a case report. Journal of endodontics. 2003; 29(8): 538-539.
• Bakland LK. Management of traumatically injured pulps in immature teeth using MTA. Journal of the California Dental Association. 2000; 28(11): 855.
• Kim E, Jou YT. A supernumerary tooth fused to the facial surface of a maxillary permanent central incisor: case report. Journal of Endodontics. 2000; 26(1): 45-48.
• Cummings GR, Torabinejad M. RS 53 Mineral trioxide aggregate (MTA) as an isolating barrier for internal bleaching. Journal of Endodontics. 1995; 21(4): 228.
• Zafar K, Jamal S, Ghafoor R. Bio-active cements-Mineral Trioxide Aggregate based calcium silicate materials: a narrative review. J Pak Med Assoc. 2020;70(3):497-504.
• Savin C, Balan A, Sirghe A, Gavrila L, Nicolau A, Mihalaş E. Mineral trioxide aggregate use in children’s primary and permanent teeth. International Journal of Medical Dentistry. 2019; 23(3).
• Bozeman TB, Lemon RR, Eleazer PD. Elemental analysis of crystal precipitate from gray and white MTA. Journal of endodontics. 2006; 32(5): 425-428.
• Torabinejad M, Chivian N. Clinical applications of mineral trioxide aggregate. Journal of endodontics. 1999; 25(3): 197-205.
• Dutta A, Saunders WP. Calcium silicate materials in endodontics. Dental Update. 2014; 41(8): 708-722.
• Camilleri J. Hydration characteristics of Biodentine and Theracal used as pulp capping materials. Dental Materials. 2014; 30(7): 709-715.
• Bani M, Sungurtekin-Ekçi E, Odabaş ME. Efficacy of Biodentine as an apical plug in nonvital permanent teeth with open apices: an in vitro study. BioMed research international. 2015.
• Nowicka A, Wilk G, Lipski M, Kołecki J, Buczkowska-Radlińska J. (2015). Tomographic evaluation of reparative dentin formation after direct pulp capping with Ca (OH) 2, MTA, Biodentine, and dentin bonding system in human teeth. Journal of endodontics. 2015; 41(8): 1234-1240.
• Kogan P, He J, Glickman GN, Watanabe I. The effects of various additives on setting properties of MTA. Journal of endodontics. 2006; 32(6): 569-572.
• Gandolfi MG, Taddei P, Siboni F, Modena E, Ciapetti G, Prati C. Development of the foremost light-curable calcium-silicate MTA cement as root-end in oral surgery. Chemical–physical properties, bioactivity and biological behavior. Dental Materials. 2011; 27(7): e134-e157.
• Rouhani A, Azimi N, Akbari M, Ahmadpour A, Ashrafpour E. Effect of Adding Nano Size Silica on Setting Time and Porosity of Mineral Trioxide Aggregate. Iranian Endodontic Journal. 2018; 14(3): 197-201.
• Dianat O, Mahdian A, Sanagoo N, Mozayeni MA, Eskandarion S. Setting Time and Surface Microhardness of Mineral Trioxide Aggregate and 1% and 5% Fluoride-Doped Mineral Trioxide Aggregate Mixed with Water and Gel-like Polymer. Iranian Endodontic Journal. 2018 ; 14(4): 265-270.
• Raghavendra SS, Jadhav GR, Gathani KM, Kotadia P. Bioceramics in endodontics–a review. Journal of Istanbul University Faculty of Dentistry. 2017; 51(3) Suppl 1: S128.
• Mondelli JAS, Hoshino RA, Weckwerth PH, Cerri PS, Leonardo RT, Guerreiro‐Tanomaru JM, da Silva GF. Biocompatibility of mineral trioxide aggregate flow and biodentine. International Endodontic Journal. 2019; 52(2): 193-200.
• Lin PY, Chen HS, Wang YH, Tu YK. Primary molar pulpotomy: a systematic review and network meta-analysis. Journal of Dentistry. 2014; 42(9): 1060-1077.
• Camilleri J. Color stability of white mineral trioxide aggregate in contact with hypochlorite solution. Journal of endodontics. 2014; 40(3): 436-440.
• Camilleri J. Staining potential of Neo MTA Plus, MTA Plus, and Biodentine used for pulpotomy procedures. Journal of endodontics. 2015; 41(7): 1139-1145.
• Siboni F, Taddei P, Prati C, Gandolfi MG. Properties of Neo MTA Plus and MTA Plus cements for endodontics. International endodontic journal .2017; 50: e83-e94.
• Birant S, Gokalp M, Duran Y, Koruyucu M, Akkoc T, Seymen F. Cytotoxicity of NeoMTA Plus, ProRoot MTA and Biodentine on human dental pulp stem cells. Journal of Dental Sciences. 2020.
• Jacob VP, Paião LI, da Silva ACG, Magario MKW, Kaneko TY, Martins CM, Mori GG. Antimicrobial action of NeoMTA Plus on mono-and dual-species biofilms of Enterococcus faecalis and Candida albicans: An in vitro study. Archives of Oral Biology. 2020: 120, 104925.
• Delikan E, Aksu S. Comparison of the sealing ability of apical plug materials in simulated open apices: An in vitro study. Journal of Oral Research and Review. 2020; 12(2): 70.
• Vilela Teixeira AB, de Carvalho Honorato Silva C, Alves OL, Cândido dos Reis A. Endodontic sealers modified with silver vanadate: antibacterial, compositional, and setting time evaluation. BioMed research international. 2019.
• Trišić, D., Ćetenović, B., Zdravković, N., Marković, T., Dojčinović, B., Jokanović, V., & Marković, D. Antibacterial effects of new endodontic materials based on calcium silicates. Vojnosanitetski pregled. 2019; 76(4).
• Zarrabi MH, Javidi M, Naderinasab M, Gharechahi M. Comparative evaluation of antimicrobial activity of three cements: new endodontic cement (NEC), mineral trioxide aggregate (MTA) and Portland. Journal of oral science. 2009; 51(3): 437-442.
• Fransson H, Wolf E, Petersson K. Formation of a hard tissue barrier after experimental pulp capping or partial pulpotomy in humans: an updated systematic review. International endodontic journal. 2016; 49(6): 533-542.
• Tsai CL, Ke MC, Chen YH, Kuo HK, Yu HJ, Chen CT, Wu PC. Mineral trioxide aggregate affects cell viability and induces apoptosis of stem cells from human exfoliated deciduous teeth. BMC Pharmacology and Toxicology. 2018; 19(1): 1-10.
• Taha NA, Safadi RA, Alwedaie MS. Biocompatibility evaluation of EndoSequence root repair paste in the connective tissue of rats. Journal of endodontics. 2016; 42(10): 1523-1528.
• Samyuktha V, Ravikumar P, Nagesh B, Ranganathan K, Jayaprakash T, Sayesh V. Cytotoxicity evaluation of root repair materials in human-cultured periodontal ligament fibroblasts. Journal of conservative dentistry: JCD. 2014; 17(5): 467.
• Bhavana V, Chaitanya KP, Gandi P, Patil J, Dola B, Reddy RB. Evaluation of antibacterial and antifungal activity of new calcium-based cement (Biodentine) compared to MTA and glass ionomer cement. Journal of conservative dentistry: JCD. 2015; 18(1): 44.
• Costa F, Gomes PS, Fernandes MH. Osteogenic and angiogenic response to calcium silicate–based endodontic sealers. Journal of Endodontics. 2016; 42(1): 113-119.
• Giraud T, Jeanneau C, Bergmann M, Laurent P, About I. Tricalcium silicate capping materials modulate pulp healing and inflammatory activity in vitro. Journal of Endodontics. 2018: 44(11): 1686-1691.
• Miller AA, Takimoto K, Wealleans J, Diogenes A. Effect of 3 bioceramic materials on stem cells of the apical papilla proliferation and differentiation using a dentin disk model. Journal of endodontics. 2018; 44(4): 599-603.
• Du J, Lu Y, Song M, Yang L, Liu J, Chen X, Wang, Y. Effects of ERK/p38 MAPKs signaling pathways on MTA-mediated osteo/odontogenic differentiation of stem cells from apical papilla: a vitro study. BMC Oral Health. 2020; 20(1): 1-9.
• Chin JS, Thomas MB, Locke M, Dummer PMH. A survey of dental practitioners in Wales to evaluate the management of deep carious lesions with vital pulp therapy in permanent teeth. British dental journal. 2016; 221(6): 331-338.
• Silva LAB, Pieroni KAMG, Nelson-Filho P, Silva RAB, Hernandéz-Gatón P, Lucisano MP, de Queiroz AM. Furcation perforation: periradicular tissue response to biodentine as a repair material by histopathologic and indirect immunofluorescence analyses. Journal of Endodontics. 2017; 43: 1137-1142.
• El-Khodary HM, Farsi DJ, Farsi NM, Zidan AZ. Sealing Ability of Four Calcium Containing Cements used for Repairing Furcal Perforations in Primary Molars: An in vitro study. The journal of contemporary dental practice. 2015; 16(9): 733.
• Alsulaimani RS. Immediate and delayed repair of 2 sizes of Furcal perforations in dogs' teeth using mineral trioxide aggregate cement. Journal of endodontics. 2018; 44(6): 1000-1006.
• Pace R, Giuliani V, Pagavino G. Mineral trioxide aggregate as repair material for furcal perforation: case series. Journal of endodontics. 2008; 34(9): 1130-1133.
• Shah S, De R, Kishan KV, Ravinathanan M, Shah N, Solanki N. (2019). Comparative evaluation of sealing ability of calcium sulfate with self-etch adhesive, mineral trioxide aggregate plus, and bone cement as furcal perforation repair materials: An In vitro dye extraction study. 2019.
• Kunhappan S, Kunhappan N, Saraf KK, Kridutt V. Nonsurgical endodontic treatment of teeth associated with large periapical lesion using triple antibiotic paste and mineral trioxide aggregate apical plug: A case series. Journal of conservative dentistry: JCD. 2017; 20(2): 141.
• Mahmoud SH, El-Negoly SA, El-Din AMZ, El-Zekrid MH, Grawish LM, Grawish HM, Grawish ME. Biodentine versus mineral trioxide aggregate as a direct pulp capping material for human mature permanent teeth–A systematic review. Journal of conservative dentistry: JCD. 2018; 21(5): 466.
• Dammaschke T, Nowicka A, Lipski M, Ricucci D. Histological evaluation of hard tissue formation after direct pulp capping with a fast-setting mineral trioxide aggregate (RetroMTA) in humans. Clinical oral investigations. 2019; 23(12): 4289-4299.
• Solak H, Merıç Tunca Y, Yılmaz T. (2019). pH changes of five different calcium hydroxide and mineral trioxıde aggregate mixtures used for intracanal medicaton and pulp capping. International Journal of Medical Dentistry. 2019; 23(3).
• Refaei P, Jahromi MZ, Moughari AAK. Comparison of the microleakage of mineral trioxide aggregate, calcium-enriched mixture cement, and Biodentine orthograde apical plug. Dental Research Journal. 2020; 17(1): 66.
• Asgary S, Eghbal MJ, Fazlyab M, Baghban AA, Ghoddusi J. Five-year results of vital pulp therapy in permanent molars with irreversible pulpitis: a non-inferiority multicenter randomized clinical trial. Clinical oral investigations 2015; 19(2): 335-341.
• Sharaan M, Ali A. Could mineral trioxide aggregate pulpotomy replace root canal treatment in children and adolescents?. Endodontic Practice Today. 2019; 13(3).
• Öznurhan F, Kayabaşı M, Keskus B. Evaluation of Long-Term Results of Two Different Calcium Silicate Based Materials in Primary Molar Teeth Vital Pulpotomies: An Invivo Study. Cumhuriyet Dental Journal. 23(1): 45-51.
• Chen Y, Chen X, Zhang Y, Zhou F, Deng,J, Zou J, Wang Y. (2019). Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis. BMC oral health. 2019; 19(1): 227.
• Perić T, Marković D, Petrović B. Mineral trioxide aggregate for the treatment of external root resorption in an avulsed immature tooth-ten years of follow-up. Srpski arhiv za celokupno lekarstvo. 2019; 00: 103-103.
• Setzer FC, Shou H, Kulwattanaporn P, Kohli MR, Karabucak B. Outcome of crown and root resection: A systematic review and meta-analysis of the literature. Journal of Endodontics. 2019; 45(1): 6-19.
• Adl A, Javanmardi S, Abbaszadegan A. Assessment of tooth discoloration induced by biodentine and white mineral trioxide aggregate in the presence of blood. Journal of Conservative Dentistry; JCD. 2019; 22(2): 164.
• Shokouhinejad N, Nekoofar MH, Pirmoazen S, Shamshiri AR, Dummer PM. Evaluation and comparison of occurrence of tooth discoloration after the application of various calcium silicate–based cements: an ex vivo study. Journal of endodontics. 2016; 42(1): 140-144.
• Madani Z, Alvandifar S, Bizhani A. Evaluation of tooth discoloration after treatment with mineral trioxide aggregate, calcium-enriched mixture, and Biodentine® in the presence and absence of blood. Dental Research Journal. 2019; 16(6): 377.
• Arman M, Khalilak Z, Rajabi M, Esnaashari E, Saati K. In vitro spectrophotometry of tooth discoloration induced by tooth-colored mineral trioxide aggregate and calcium-enriched mixture cement. Iranian endodontic journal. 2015; 10(4): 226.