ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ?

Beyza Olukpınar Genç; Tanju Kadir

doi:10.15311/selcukdentj.972749

ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ?

Abstract

Alzheimer hastalığı (AH), antimikrobiyal peptit olarak bilinen β-amiloid birikimi ve anormal şekilde fosforile tau proteinlerinden oluşan nörofibriler yumakların varlığı ile karakterize nöroinflamatuar ve nörodejeneratif bir hastalık olarak tanımlanır. Periodontal hastalığın patogenezinde rol oynayan Porphyromonas gingivalis (P. gingivalis) AH ile ilişkili önemli bakteriyel patojenden biri olarak kabul edilmiştir. Ağız boşluğunda bulunan bu bakteriye ait metabolik yan ürünlerinin ağız boşluğunun ötesinde bağışıklık sistemini aktive edebildiği böylece sistemik koşulların gelişimini teşvik edebildiği gözlenmiştir. Artan sayıda yapılan çalışmalar P. gingivalis'in beyin kolonizasyonunun inflamatuar ve dejeneratif durumu birbirine bağlayabileceğini bildirmiştir. AH'li kişilerin beyinlerinden alınan otopsi örneklerinde ve beyin omurilik sıvılarında P. gingivalis infiltrasyonunun varlığı tespit edilmiştir. P. gingivalis tarafından üretilen proteaz sınıfı olan gingipainlerin AH'li bireylerin beyinlerinden alınan örneklerde nöronlar, tau yumakları ve β-amiloid ile ilişkili olduğu bulunmuştur. Yerleşik beyin enfeksiyonları olan farelere oral yoldan verilen gingipain inhibitörlerinin beyindeki P. gingivalis DNA bolluğunu ve bakteri enfeksiyonunun nörotoksik etkilerini azalttığı bildirilmiştir. Dolayısıyla gingipain inhibisyonu hem periodontitis hem de AH'nın tedavisine potansiyel bir yaklaşım sağlayabildiği düşünülmüştür. Bu derlemenin amacı, periodontal hastalık ile Alzheimer hastalığı ve demans arasında nedensel bir ilişki olasılığını değerlendirmek ve literatürlerdeki daha fazla araştırma gerektiren temel boşlukları belirlemek olmuştur.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Dentistry

Journal Section

Review

Authors

Beyza Olukpınar Genç ^*
0000-0003-2470-9404
Türkiye

Tanju Kadir
0000-0002-4668-9988
Türkiye

Publication Date

August 24, 2022

Submission Date

July 19, 2021

Acceptance Date

February 22, 2022

Published in Issue

Year 2022 Volume: 9 Number: 2

DOI

https://doi.org/10.15311/selcukdentj.972749

IZ

https://izlik.org/JA26PK98JE

Cite

RIS / Bibtex

APA

Olukpınar Genç, B., & Kadir, T. (2022). ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ? Selcuk Dental Journal, 9(2), 675-684. https://doi.org/10.15311/selcukdentj.972749

AMA

1.Olukpınar Genç B, Kadir T. ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ? Selcuk Dent J. 2022;9(2):675-684. doi:10.15311/selcukdentj.972749

Chicago

Olukpınar Genç, Beyza, and Tanju Kadir. 2022. “ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ?”. Selcuk Dental Journal 9 (2): 675-84. https://doi.org/10.15311/selcukdentj.972749.

EndNote

Olukpınar Genç B, Kadir T (August 1, 2022) ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ? Selcuk Dental Journal 9 2 675–684.

IEEE

[1]B. Olukpınar Genç and T. Kadir, “ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ?”, Selcuk Dent J, vol. 9, no. 2, pp. 675–684, Aug. 2022, doi: 10.15311/selcukdentj.972749.

ISNAD

Olukpınar Genç, Beyza - Kadir, Tanju. “ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ?”. Selcuk Dental Journal 9/2 (August 1, 2022): 675-684. https://doi.org/10.15311/selcukdentj.972749.

JAMA

1.Olukpınar Genç B, Kadir T. ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ? Selcuk Dent J. 2022;9:675–684.

MLA

Olukpınar Genç, Beyza, and Tanju Kadir. “ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ?”. Selcuk Dental Journal, vol. 9, no. 2, Aug. 2022, pp. 675-84, doi:10.15311/selcukdentj.972749.

Vancouver

1.Beyza Olukpınar Genç, Tanju Kadir. ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ? Selcuk Dent J. 2022 Aug. 1;9(2):675-84. doi:10.15311/selcukdentj.972749

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