Bifosfonatlar ve çene kemiğinde görülen osteonekroz

Year 2015, Volume: 2 Issue: 2, 91 - 101, 01.08.2015

Elif Tarım Ertaş Meral Yırcalı Atıcı

https://doi.org/10.15311/1441.272614

Cited By: 2

Abstract

Pirofosfatların sentetik analogları olan
bifosfonatlar kemik metabolizması ile ilgili
birçok hastalığın tadavisinde yaygın olarak
kullanılmaktadırlar. Bifosfonatların kullanımının
hastaya sağladığı yarar yanında, çenelerde
osteonekroz oluşması gibi yan etkileri de
vardır. Bifosfonata bağlı gelişen
osteonekrozun tedavisinin zorluğu ve hastanın
hayatını olumsuz etkilemesi erken tanı ve
koruyucu önlemleri önemli yapar. Bu nedenle
bisfosfonat osteonekrozuna ait klinik ve
radyografik özelliklerin iyi bilinmesi erken tanı
ve tedavi açısından önem taşımaktadır.
Bu derlemenin amacı bifosfonatlar ile ilgili bilgi
vermek, bifosfonata bağlı çenelerde görülen
osteonekroz tanısında önemli olan noktalara
dikkat çekmektir. Ayrıca, hastalar için çok
önemli olan osteonekrozdan korunma ve
önleyici tedbirlere de değinilecektir.

Keywords

Bifosfonat, çene, osteonekroz, risk faktörleri

Bisphosphonates and osteonecrosis of the jaws

Abstract

Bisphosphonates, which are synthetic analogues of pyrophosphates are widely used in treatment of in many diseases of bone metabolism. Administration of biphosphanates may cause adverse effects such as osteonecrosis of the jaws. Preventive procedures and early diagnosis are important due to the difficult osteonecrosis management and adverse effects of the patient life. For this reason, it is important to identify the clinical and radiographic features of the bisphosohonate-related osteonecrosis of the jaws in order to provide early diagnosis and treatment.The aim of this review is to give the knowledge about bisphosphonates and to draw attention to the important point of diagnosis of bisphosphonate-related osteonecrosis of the jaws. In addition, prevention and protection of osteonecrosis, which are very important for patients, will be discussed.

Keywords

Bisphosphonates, jaw, osteonecrosis, risk factors

References

• Abu-Id MH, Warnke PH, Gottschalk J, Springer I, Wiltfang J, Acil Y, Russo PA, Kreusch T, 2008. "Bis-phossy jaws" - high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. J Craniomaxillofac Surg, 36, 95-103.
• Adachi JD, Saag KG, Delmas PD, Liberman UA, Emkey RD, Seeman E, Lane NE, Kaufman JM, Poubelle PE, Hawkins F, Correa-Rotter R, Menkes CJ, Rodriguez-Portales JA, Schnitzer TJ, Block JA, Wing J, McIlwain HH, Westhovens R, Brown J, Melo-Gomes JA, Gruber BL, Yanover MJ, Leite MO, Siminoski KG, Nevitt MC, Sharp JT, Malice MP, Dumortier T, Czachur M, Carofano W, Daifotis A, 2001. Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: A randomized, double-blind, placebo-controlled extension trial. Arthritis Rheum, 44, 202-11.
• Agrillo A, Ungari C, Filiaci F, Priore P, Iannetti G, 2007. Ozone therapy in the treatment of avascular bisphosphonate-related jaw osteonecrosis. J Craniofac Surg, 18, 1071-5.
• Aoyagi T, Morii T, Ohtsuka K, Ohnishi H, Tajima T, Yoshiyama A, Mochizuki K, Satomi K, Ichimura S, 2013. Lung cancer cell line sensitivity to zoledronic acid is bax-dependent. Anticancer Res, 33, 5357-63.
• Arce K, Assael LA, Weissman JL, Markiewicz MR, 2009. Imaging findings in bisphosphonate-related osteonecrosis of jaws. J Oral Maxillofac Surg, 67, 75-84.
• Ariji Y, Izumi M, Gotoh M, Naitoh M, Katoh M, Kuroiwa Y, Obayashi N, Kurita K, Shimozato K, Ariji E, 2008. Mri features of mandibular osteomyelitis: Practical criteria based on an association with conventional radiography features and clinical classification. Oral Surg O