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Tip 2 Diyabetli Bireylerde Diyetle Omega-3 Alımının Metabolik Risk Parametreleriyle İlişkisi

Year 2025, Volume: 2 Issue: 1, 8 - 16, 29.09.2025

Abstract

Amaç: Bu çalışma, Tip 2 diyabetli bireylerde diyetle omega-3 alımının metabolik risk parametreleriyle ilişkisinin araştırılması amacıyla yürütülmüştür.
Yöntem: Kesitsel tipteki araştırma, beslenme ve diyet polikliniğine başvuran Tip 2 diyabet (Tip 2 DM) tanılı 76 birey ile gerçekleştirilmiştir. Veriler Tanıtıcı Bilgi Formu ve Omega-3 İçeren Besinlerin Tüketim Sıklığı Formu ile toplanmıştır. Bireylerin antropometrik ölçümleri araştırmacılar tarafından alınmış, biyokimyasal ölçümleri hasta dosyalarından kaydedilmiştir. Veri analizinde Mann Whitney U testi ve Spearman korelasyon analizi kullanılmıştır.
Sonuçlar: Kadınlarda günlük omega-3 tüketim miktarı ortalama 2,17±0,99 g iken; erkeklerde 2,28±1,43g’dır. Omega-3, Eikosapentaenoik Asit (EPA) tüketim miktarı metabolik risk parametreleriyle ilişkili değildir (p>0.05). Bireylerin Dokosaheksaenoik Asit (DHA) tüketim miktarı ile High Density Lipoprotein (HDL) kolesterol değerleri arasında istatiksel olarak anlamlı negatif yönde zayıf ilişki saptanırken (r=-0,245, p<0,05), DHA tüketim miktarı ile diğer metabolik risk parametreleri arasında ilişki saptanamamıştır (p>0,05).
Tartışma: Bu çalışmada Omega-3, eikosapentaenoik asit (EPA) tüketim miktarının metabolik risk parametreleriyle ilişkili olmadığı, DHA tüketim miktarı arttıkça metabolik risk paramaterlerinden HDL kolesterolun azaldığı ve DHA tüketim miktarının diğer metabolik risk parametreleriyle ilişkili olmadığı saptanmıştır.

References

  • Ahmad, E., Lim, S., Lamptey, R., Webb, D. R., & Davies, M. J. (2022). Type 2 diabetes. The Lancet, 400(10365), 1803–1820.
  • Atar, M. J. H., Hajianfar, H., & Bahonar, A. (2012). The effects of omega-3 on blood pressure and the relationship between serum visfatin level and blood pressure in patients with type II diabetes. ARYA Atherosclerosis, 8(1), 27.
  • Bernasconi, A. A., Wilkin, A. M., Roke, K., & Ismail, A. (2022). Development of a novel database to review and assess the clinical effects of EPA and DHA omega-3 fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids, 183, 102458.
  • Brown, T. J., Brainard, J., Song, F., Wang, X., Abdelhamid, A., & Hooper, L. (2019). Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: Systematic review and meta-analysis of randomised controlled trials. BMJ, 366.
  • Calder, P. C. (2015). Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1851(4), 469-484.
  • Cartolano, F. D. C., Dias, G. D., Miyamoto, S., & Damasceno, N. R. T. (2022). Omega-3 fatty acids improve functionality of high-density lipoprotein in individuals with high cardiovascular risk: A randomized, parallel, controlled and double-blind clinical trial. Frontiers in Nutrition, 8, 767535.
  • Chen, C., Yu, X., & Shao, S. (2015). Effects of omega-3 fatty acid supplementation on glucose control and lipid levels in type 2 diabetes: A meta-analysis. PLoS One, 10(10), e0139565.
  • Chen, G.C., Arthur, R., Qin, L. Q., Chen, L. H., Mei, Z., & Zheng, Y. (2021). Association of oily and nonoily fish consumption and fish oil supplements with incident type 2 diabetes: A large population-based prospective study. Diabetes Care, 44(3), 672–680.
  • De Goede, J., Verschuren, W. M., Boer, J. M., Kromhout, D., & Geleijnse, J. M. (2012). Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. PLoS One, 7(4), e33866.
  • De Souza, D. R., da Silva Pieri, B. L., Comim, V. H., de Oliveira Marques, S., Luciano, T. F., & Rodrigues, M. S. (2020). Fish oil reduces subclinical inflammation, insulin resistance, and atherogenic factors in overweight/obese type 2 diabetes mellitus patients: A pre-post pilot study. Journal of Diabetes and its Complications, 34(5), 107553.
  • Díaz-Rizzolo, D. A., Miro, A., & Gomis, R. (2022). Prevention of type 2 diabetes through sardines consumption: An integrative review. Food Reviews International, 38(sup1), 317–335.
  • Díaz-Rizzolo, D. A., Serra, A., Colungo, C., Sala-Vila, A., Sisó-Almirall, A., & Gomis, R. (2021). Type 2 diabetes preventive effects with a 12-month sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial. Clinical Nutrition, 40(5), 2587–2598.
  • Djousse, L., Gaziano, J. M., Buring, J. E., & Lee, I. M. (2011). Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. The American Journal of Clinical Nutrition, 93(1), 143–150.
  • Emami, M. R., & Salim, S. J. (2024). The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial. Human Nutrition & Metabolism, 36, 200248.
  • Faul, F., Erdfelder, E., Buchner, A., & Lang, A. G. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175–191.
  • Faul, F., Erdfelder, E., Buchner, A., & Lang, A. G. (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149–1160.
  • Fielding, B. A. (2017). Ω-3 index as a prognosis tool in cardiovascular disease. Current Opinion in Clinical Nutrition & Metabolic Care, 20(5), 360–365.
  • Flock, M. R., Skulas-Ray, A. C., Harris, W. S., Etherton, T. D., Fleming, J. A., & Kris-Etherton, P. M. (2013). Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: A dose-response randomized controlled trial. Journal of the American Heart Association, 2(6).
  • Garcia-Molina, L., Lewis-Mikhael, A. M., Riquelme-Gallego, B., Cano-Ibanez, N., Oliveras-Lopez, M. J., & Bueno-Cavanillas, A. (2020). Improving type 2 diabetes mellitus glycaemic control through lifestyle modification implementing diet intervention: A systematic review and meta-analysis. European Journal of Nutrition, 59(4), 1313–1328.
  • Golzari, M. H., Javanbakht, M. H., Ghaedi, E., Mohammadi, H., & Djalali, M. (2018). Effect of Eicosapentaenoic acid (EPA) supplementation on cardiovascular markers in patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(3), 411–415.
  • Haghravan, S., Keshavarez, S., Mazaheri, R., Alizadeh, Z., & Mansournia, M. A. (2016). Effect of Omega-3 PUFAs Supplementation with Lifestyle Modification on Anthropometric Indices and Vo2 max in Overweight Women. Archives of Iranian Medicine, 19(5), 342–347.
  • Innes, J. K., & Calder, P. C. (2020). Marine omega-3 (n-3) fatty acids for cardiovascular health: An update for 2020. International Journal of Molecular Sciences, 21(4), 1362.
  • Khalili, L., Valdes-Ramos, R., & Harbige, L. S. (2021). Effect of n-3 (Omega-3) polyunsaturated fatty acid supplementation on metabolic and inflammatory biomarkers and body weight in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of RCTs. Metabolites, 11(11), 742.
  • Kosti, R. I., Kasdagli, M. I., Kyrozis, A., Orsini, N., Lagiou, P., & Taiganidou, F. (2022). Fish intake, n-3 fatty acid body status, and risk of cognitive decline: A systematic review and a dose–response meta-analysis of observational and experimental studies. Nutrition Reviews, 80(6), 1445–1458.
  • Kumari, R., Kumar, S., & Kant, R. (2019). An update on metabolic syndrome: Metabolic risk markers and adipokines in the development of metabolic syndrome. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(4), 2409–2417.
  • Moosheer, S. M., Waldschütz, W., Itariu, B. K., Brath, H., & Stulnig, T. M. (2014). A protein-enriched low glycemic index diet with omega-3 polyunsaturated fatty acid supplementation exerts beneficial effects on metabolic control in type 2 diabetes. Primary Care Diabetes, 8(4), 308–314.
  • O’Mahoney, L. L., Matu, J., Price, O. J., Birch, K. M., Ajjan, R. A., & Farrar, D. (2018). Omega-3 polyunsaturated fatty acids favourably modulate cardiometabolic biomarkers in type 2 diabetes: A meta-analysis and meta-regression of randomized controlled trials. Cardiovascular Diabetology, 17(1), 98.
  • Pekcan, G. (2012). Diyet El Kitabı, Beslenme Durumunun Saptanması, 2.Baskı.
  • Pertiwi, K., Wanders, A. J., Harbers, M. C., Küpers, L. K., Soedamah-Muthu, S. S., & de Goede, J. (2020). Plasma and dietary linoleic acid and 3-year risk of type 2 diabetes after myocardial infarction: A prospective analysis in the Alpha Omega Cohort. Diabetes Care, 43(2), 358–365.
  • Rakıcıoğlu, N., Başoglu, S. & Samur F. (2017). Diyetisyenler için hasta izleme rehberi/ağırlık yönetimi el kitabı. Türkiye Cumhuriyeti Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü.
  • Redruello-Requejo, M., Samaniego-Vaesken, M. D. L., Puga, A. M., Montero-Bravo, A., Ruperto, M., & Rodríguez-Alonso, P. (2023). Omega-3 and omega-6 polyunsaturated fatty acid intakes, determinants and dietary sources in the Spanish population: Findings from the ANIBES study. Nutrients, 15(3), 562.
  • Rodriguez, D., Lavie, C. J., Elagizi, A., & Milani, R. V. (2022). Update on omega-3 polyunsaturated fatty acids on cardiovascular health. Nutrients, 14(23), 5146.
  • Salman, H. B., Salman, M. A., & Akal, E. Y. (2022). The effect of omega-3 fatty acid supplementation on weight loss and cognitive function in overweight or obese individuals on weight-loss diet. Nutricion Hospitalaria, 39(4), 803–813.
  • Sellem, L., Eichelmann, F., Jackson, K. G., Wittenbecher, C., Schulze, M. B., & Lovegrove, J. A. (2023). Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: A secondary analysis of a randomized trial. The American Journal of Clinical Nutrition, 117(6), 1248–1261.
  • Shin, J., Zhou, X., Tan, J. T. M., Hyppönen, E., Benyamin, B., & Lee, S. H. (2022). Lifestyle modifies the diabetes-related metabolic risk, conditional on individual genetic differences. Frontiers in Genetics, 13, 759309.
  • Taheri, S., Zaghloul, H., Chagoury, O., Elhadad, S., Ahmed, S. H., & El Khatib, N. (2020). Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): An open-label, parallel-group, randomised controlled trial. The Lancet Diabetes & Endocrinology, 8(6), 477–489.
  • Tandi, R. K., Hazique, M., Rehman, S., Gaddam, N., Hana, V. S., Sajjad, T., Mehmood, N., & Kauser, H. (2022). Prevalence of pre-diabetes and cardio-metabolic risk factors in first degree relatives of patients with type-II DM. International Journal of Advanced Community Medicine, 5(2), 35–37.
  • Tani, S., Matsuo, R., & Matsumoto, N. (2019). A longitudinal study of the association of the eicosapentaenoic acid/arachidonic acid ratio derived from fish consumption with the serum lipid levels: A pilot study. Heart and Vessels, 34, 189–196.
  • Thompson, M., Hein, N., Hanson, C., Smith, L. M., Anderson-Berry, A., & Richter, C. K. (2019). Omega-3 fatty acid intake by age, gender, and pregnancy status in the United States: National health and nutrition examination survey 2003–2014. Nutrients, 11(1), 177.
  • World Health Organization (WHO). A healthy lifestyle factsheets 2010. https://www.who.int/europe/news-room/fact-sheets/item/a-healthy-lifestyle---who-recommendations#:~:text=Note.,24.9%20as%20a%20normal%20BMI Erişim tarihi: 31.07.2025.
  • Xiao, Y., Zhang, Q., Liao, X., Elbelt, U., & Weylandt, K. H. (2022). The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis. Prostaglandins, Leukotrienes and Essential Fatty Acids, 182, 102456. Yanai, H., & Tada, N. (2018). Effects of consumption of various fatty acids on serum HDL-cholesterol levels. Journal of Endocrinology and Metabolism, 8(5), 94–99.
  • Zhang, Y. Y., Liu, W., Zhao, T. Y., & Tian, H. M. (2017). Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: A meta-analysis of randomized clinical trials. The Journal of Nutrition, Health and Aging, 21(2), 187–192.
  • Zhang, Y., Ren, E., Zhang, C., Wang, Y., Chen, X., & Li, L. (2024). The protective role of oily fish intake against type 2 diabetes: Insights from a genetic correlation and Mendelian randomization study. Frontiers in Nutrition, 11, 1288886.
  • Zhou, Y., Tian, C., & Jia, C. (2012). Association of fish and n-3 fatty acid intake with the risk of type 2 diabetes: A meta-analysis of prospective studies. British Journal of Nutrition, 108(3), 408–417.

Relationship of Dietary Omega-3 Intake with Metabolic Risk Parameters in Individuals with Type 2 Diabetes

Year 2025, Volume: 2 Issue: 1, 8 - 16, 29.09.2025

Abstract

Purpose: This study was conducted to investigate the relationship between dietary omega-3 intake and metabolic risk parameters in individuals with Type 2 diabetes.
Methods: The cross-sectional study was carried out with 76 individuals diagnosed with Type 2 diabetes (Type 2 DM) who applied to the nutrition and diet outpatient clinic. Data were collected using the Descriptive Information Form and the Frequency of Consumption of Foods Containing Omega-3 Form. Anthropometric measurements of the individuals were taken by the researchers and biochemical measurements were recorded from the patient files. Mann Whitney U test and Spearman correlation analysis were used for data analysis.
Results: The mean daily omega-3 consumption was 2.17±0.99 g in women and 2.28±1.43 g in men. Omega-3, Eicosapentaenoic Acid (EPA) consumption was not associated with metabolic risk parameters (p>0.05). There was a statistically significant negative weak correlation between the amount of Docosahexaenoic Acid (DHA) consumption and High Density Lipoprotein (HDL) cholesterol values (r=-0.245, p<0.05), while there was no correlation between DHA consumption and other metabolic risk parameters (p>0.05).
Conclusion: In this study, it was found that the amount of omega-3, eicosapentaenoic acid (EPA) consumption was not associated with metabolic risk parameters, HDL cholesterol, one of the metabolic risk parameters, decreased as the amount of DHA consumption increased and the amount of DHA consumption was not associated with other metabolic risk.

References

  • Ahmad, E., Lim, S., Lamptey, R., Webb, D. R., & Davies, M. J. (2022). Type 2 diabetes. The Lancet, 400(10365), 1803–1820.
  • Atar, M. J. H., Hajianfar, H., & Bahonar, A. (2012). The effects of omega-3 on blood pressure and the relationship between serum visfatin level and blood pressure in patients with type II diabetes. ARYA Atherosclerosis, 8(1), 27.
  • Bernasconi, A. A., Wilkin, A. M., Roke, K., & Ismail, A. (2022). Development of a novel database to review and assess the clinical effects of EPA and DHA omega-3 fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids, 183, 102458.
  • Brown, T. J., Brainard, J., Song, F., Wang, X., Abdelhamid, A., & Hooper, L. (2019). Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: Systematic review and meta-analysis of randomised controlled trials. BMJ, 366.
  • Calder, P. C. (2015). Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1851(4), 469-484.
  • Cartolano, F. D. C., Dias, G. D., Miyamoto, S., & Damasceno, N. R. T. (2022). Omega-3 fatty acids improve functionality of high-density lipoprotein in individuals with high cardiovascular risk: A randomized, parallel, controlled and double-blind clinical trial. Frontiers in Nutrition, 8, 767535.
  • Chen, C., Yu, X., & Shao, S. (2015). Effects of omega-3 fatty acid supplementation on glucose control and lipid levels in type 2 diabetes: A meta-analysis. PLoS One, 10(10), e0139565.
  • Chen, G.C., Arthur, R., Qin, L. Q., Chen, L. H., Mei, Z., & Zheng, Y. (2021). Association of oily and nonoily fish consumption and fish oil supplements with incident type 2 diabetes: A large population-based prospective study. Diabetes Care, 44(3), 672–680.
  • De Goede, J., Verschuren, W. M., Boer, J. M., Kromhout, D., & Geleijnse, J. M. (2012). Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. PLoS One, 7(4), e33866.
  • De Souza, D. R., da Silva Pieri, B. L., Comim, V. H., de Oliveira Marques, S., Luciano, T. F., & Rodrigues, M. S. (2020). Fish oil reduces subclinical inflammation, insulin resistance, and atherogenic factors in overweight/obese type 2 diabetes mellitus patients: A pre-post pilot study. Journal of Diabetes and its Complications, 34(5), 107553.
  • Díaz-Rizzolo, D. A., Miro, A., & Gomis, R. (2022). Prevention of type 2 diabetes through sardines consumption: An integrative review. Food Reviews International, 38(sup1), 317–335.
  • Díaz-Rizzolo, D. A., Serra, A., Colungo, C., Sala-Vila, A., Sisó-Almirall, A., & Gomis, R. (2021). Type 2 diabetes preventive effects with a 12-month sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial. Clinical Nutrition, 40(5), 2587–2598.
  • Djousse, L., Gaziano, J. M., Buring, J. E., & Lee, I. M. (2011). Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. The American Journal of Clinical Nutrition, 93(1), 143–150.
  • Emami, M. R., & Salim, S. J. (2024). The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial. Human Nutrition & Metabolism, 36, 200248.
  • Faul, F., Erdfelder, E., Buchner, A., & Lang, A. G. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2), 175–191.
  • Faul, F., Erdfelder, E., Buchner, A., & Lang, A. G. (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149–1160.
  • Fielding, B. A. (2017). Ω-3 index as a prognosis tool in cardiovascular disease. Current Opinion in Clinical Nutrition & Metabolic Care, 20(5), 360–365.
  • Flock, M. R., Skulas-Ray, A. C., Harris, W. S., Etherton, T. D., Fleming, J. A., & Kris-Etherton, P. M. (2013). Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: A dose-response randomized controlled trial. Journal of the American Heart Association, 2(6).
  • Garcia-Molina, L., Lewis-Mikhael, A. M., Riquelme-Gallego, B., Cano-Ibanez, N., Oliveras-Lopez, M. J., & Bueno-Cavanillas, A. (2020). Improving type 2 diabetes mellitus glycaemic control through lifestyle modification implementing diet intervention: A systematic review and meta-analysis. European Journal of Nutrition, 59(4), 1313–1328.
  • Golzari, M. H., Javanbakht, M. H., Ghaedi, E., Mohammadi, H., & Djalali, M. (2018). Effect of Eicosapentaenoic acid (EPA) supplementation on cardiovascular markers in patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(3), 411–415.
  • Haghravan, S., Keshavarez, S., Mazaheri, R., Alizadeh, Z., & Mansournia, M. A. (2016). Effect of Omega-3 PUFAs Supplementation with Lifestyle Modification on Anthropometric Indices and Vo2 max in Overweight Women. Archives of Iranian Medicine, 19(5), 342–347.
  • Innes, J. K., & Calder, P. C. (2020). Marine omega-3 (n-3) fatty acids for cardiovascular health: An update for 2020. International Journal of Molecular Sciences, 21(4), 1362.
  • Khalili, L., Valdes-Ramos, R., & Harbige, L. S. (2021). Effect of n-3 (Omega-3) polyunsaturated fatty acid supplementation on metabolic and inflammatory biomarkers and body weight in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of RCTs. Metabolites, 11(11), 742.
  • Kosti, R. I., Kasdagli, M. I., Kyrozis, A., Orsini, N., Lagiou, P., & Taiganidou, F. (2022). Fish intake, n-3 fatty acid body status, and risk of cognitive decline: A systematic review and a dose–response meta-analysis of observational and experimental studies. Nutrition Reviews, 80(6), 1445–1458.
  • Kumari, R., Kumar, S., & Kant, R. (2019). An update on metabolic syndrome: Metabolic risk markers and adipokines in the development of metabolic syndrome. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(4), 2409–2417.
  • Moosheer, S. M., Waldschütz, W., Itariu, B. K., Brath, H., & Stulnig, T. M. (2014). A protein-enriched low glycemic index diet with omega-3 polyunsaturated fatty acid supplementation exerts beneficial effects on metabolic control in type 2 diabetes. Primary Care Diabetes, 8(4), 308–314.
  • O’Mahoney, L. L., Matu, J., Price, O. J., Birch, K. M., Ajjan, R. A., & Farrar, D. (2018). Omega-3 polyunsaturated fatty acids favourably modulate cardiometabolic biomarkers in type 2 diabetes: A meta-analysis and meta-regression of randomized controlled trials. Cardiovascular Diabetology, 17(1), 98.
  • Pekcan, G. (2012). Diyet El Kitabı, Beslenme Durumunun Saptanması, 2.Baskı.
  • Pertiwi, K., Wanders, A. J., Harbers, M. C., Küpers, L. K., Soedamah-Muthu, S. S., & de Goede, J. (2020). Plasma and dietary linoleic acid and 3-year risk of type 2 diabetes after myocardial infarction: A prospective analysis in the Alpha Omega Cohort. Diabetes Care, 43(2), 358–365.
  • Rakıcıoğlu, N., Başoglu, S. & Samur F. (2017). Diyetisyenler için hasta izleme rehberi/ağırlık yönetimi el kitabı. Türkiye Cumhuriyeti Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü.
  • Redruello-Requejo, M., Samaniego-Vaesken, M. D. L., Puga, A. M., Montero-Bravo, A., Ruperto, M., & Rodríguez-Alonso, P. (2023). Omega-3 and omega-6 polyunsaturated fatty acid intakes, determinants and dietary sources in the Spanish population: Findings from the ANIBES study. Nutrients, 15(3), 562.
  • Rodriguez, D., Lavie, C. J., Elagizi, A., & Milani, R. V. (2022). Update on omega-3 polyunsaturated fatty acids on cardiovascular health. Nutrients, 14(23), 5146.
  • Salman, H. B., Salman, M. A., & Akal, E. Y. (2022). The effect of omega-3 fatty acid supplementation on weight loss and cognitive function in overweight or obese individuals on weight-loss diet. Nutricion Hospitalaria, 39(4), 803–813.
  • Sellem, L., Eichelmann, F., Jackson, K. G., Wittenbecher, C., Schulze, M. B., & Lovegrove, J. A. (2023). Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: A secondary analysis of a randomized trial. The American Journal of Clinical Nutrition, 117(6), 1248–1261.
  • Shin, J., Zhou, X., Tan, J. T. M., Hyppönen, E., Benyamin, B., & Lee, S. H. (2022). Lifestyle modifies the diabetes-related metabolic risk, conditional on individual genetic differences. Frontiers in Genetics, 13, 759309.
  • Taheri, S., Zaghloul, H., Chagoury, O., Elhadad, S., Ahmed, S. H., & El Khatib, N. (2020). Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): An open-label, parallel-group, randomised controlled trial. The Lancet Diabetes & Endocrinology, 8(6), 477–489.
  • Tandi, R. K., Hazique, M., Rehman, S., Gaddam, N., Hana, V. S., Sajjad, T., Mehmood, N., & Kauser, H. (2022). Prevalence of pre-diabetes and cardio-metabolic risk factors in first degree relatives of patients with type-II DM. International Journal of Advanced Community Medicine, 5(2), 35–37.
  • Tani, S., Matsuo, R., & Matsumoto, N. (2019). A longitudinal study of the association of the eicosapentaenoic acid/arachidonic acid ratio derived from fish consumption with the serum lipid levels: A pilot study. Heart and Vessels, 34, 189–196.
  • Thompson, M., Hein, N., Hanson, C., Smith, L. M., Anderson-Berry, A., & Richter, C. K. (2019). Omega-3 fatty acid intake by age, gender, and pregnancy status in the United States: National health and nutrition examination survey 2003–2014. Nutrients, 11(1), 177.
  • World Health Organization (WHO). A healthy lifestyle factsheets 2010. https://www.who.int/europe/news-room/fact-sheets/item/a-healthy-lifestyle---who-recommendations#:~:text=Note.,24.9%20as%20a%20normal%20BMI Erişim tarihi: 31.07.2025.
  • Xiao, Y., Zhang, Q., Liao, X., Elbelt, U., & Weylandt, K. H. (2022). The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis. Prostaglandins, Leukotrienes and Essential Fatty Acids, 182, 102456. Yanai, H., & Tada, N. (2018). Effects of consumption of various fatty acids on serum HDL-cholesterol levels. Journal of Endocrinology and Metabolism, 8(5), 94–99.
  • Zhang, Y. Y., Liu, W., Zhao, T. Y., & Tian, H. M. (2017). Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: A meta-analysis of randomized clinical trials. The Journal of Nutrition, Health and Aging, 21(2), 187–192.
  • Zhang, Y., Ren, E., Zhang, C., Wang, Y., Chen, X., & Li, L. (2024). The protective role of oily fish intake against type 2 diabetes: Insights from a genetic correlation and Mendelian randomization study. Frontiers in Nutrition, 11, 1288886.
  • Zhou, Y., Tian, C., & Jia, C. (2012). Association of fish and n-3 fatty acid intake with the risk of type 2 diabetes: A meta-analysis of prospective studies. British Journal of Nutrition, 108(3), 408–417.
There are 44 citations in total.

Details

Primary Language Turkish
Subjects Public Health Nutrition
Journal Section Research Article
Authors

Rümeysa Gerboğa 0000-0001-9885-3148

Ezgi Çoban 0009-0007-7911-1799

Kevser Tarı Selçuk 0000-0003-1766-4914

Hande Öngün Yılmaz 0000-0002-3497-567X

Sedat Arslan 0000-0002-3356-7332

Publication Date September 29, 2025
Submission Date June 30, 2025
Acceptance Date September 3, 2025
Published in Issue Year 2025 Volume: 2 Issue: 1

Cite

APA Gerboğa, R., Çoban, E., Tarı Selçuk, K., … Öngün Yılmaz, H. (2025). Tip 2 Diyabetli Bireylerde Diyetle Omega-3 Alımının Metabolik Risk Parametreleriyle İlişkisi. Syedra Sağlık Dergisi, 2(1), 8-16.