2-Aminobenzotiyazol Türevlerinin Metal Komplekslerinin Antimikrobiyal Aktivite Çalışmaları

Abstract

2-Aminobenzotiyazol ve türevlerinin genel olarak, ilaç keşfi uygulamaları, diyabet tedavilerin geliştirilmesi, epilepsi, amyotrofik lateral skleroz, analjezi, tüberküloz tedavisi ve virüs enfeksiyon uygulamaları vardır. Bu çalışmada, 2-aminobenzotiyazol (1), 2-amino-6-klorobenzotiyazol (6), 2-amino-6-metilbenzotiyazol (11) ve 2-amino-6-metoksibenzotiyazolün (16) Fe(III) (2, 7, 12, 17), Co(II) (3, 8, 13, 18), Ni(II) (4, 9, 14, 19) ve Cu(II) (5, 10, 15, 20) kompleksleri, literatürde bulunan yöntemle sentezlenmiştir. Sentezlenen kompleks bileşiklerin (1-20) yapıları, Atomik Absorpsiyon Spektroskopisi (AAS) uygulanarak önerilmiştir. Ayrıca, 1-20'nin antimikrobiyal özellikleri Candida albicans'a (antifungal aktivite) ve Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis’e (antibakteriyel aktivite) karşı da test edilmiştir. Sonuçlar, kontrol bileşikleri Flukonazol ve Ketokonazol (antifungal aktivite) ve Vankomisin, Levofloksasin, Sefepim ve Kloramfenikol (antibakteriyel aktivite) kullanılarak elde edilen sonuçlarla karşılaştırılmıştır. Aktivite çalışmaları sonucunda, sentezlenen bileşikler bakteri ve mayalara karşı aktivite göstermiştir. En iyi aktivite sonuçları C. albicans mayasında 6 ve 10 nolu bileşiklerde, S. aureus bakterisinde 20 nolu bileşikte, E. faecalis bakterisinde 13 nolu bileşikte, B. subtilis bakterisinde 12, 13, 17 ve 20 nolu bileşiklerde, P. aeruginosa bakterisinde 5 ve 19 nolu bileşiklerde, E. coli bakterisinde 1, 4, 6, 9, 17 ve 20 nolu bileşiklerde ve L. monocytogenes bakterisinde 5, 6, 8, 17 ve 19 nolu bileşiklerde gözlemlenmiştir. Özellikle E. coli için 4 numaralı, C. albicans için 6 numaralı ve 10 numaralı bileşikler kontrol bileşiklerinden daha iyi aktivite göstermiştir.

Keywords

• 2-Aminobenzotiyazol
• metal kompleksi
• antibakteriyel aktivite
• antifungal aktivite

Project Number

2022–03

Antimicrobial Activity Studies of Metal Complexes of 2-Aminobenzothiazole Derivatives

Abstract

2-Aminobenzothiazole and its derivatives generally have applications in drug discovery, development of diabetes treatments, epilepsy, amyotrophic lateral sclerosis, analgesia, tuberculosis treatment, and viral infections. In this study, Fe(III) (2, 7, 12, 17), Co(II) (3, 8, 13, 18), Ni(II) (4, 9, 14, 19), and Cu(II) (5, 10, 15, 20) complexes of 2-aminobenzothiazole (1), 2-amino-6-chlorobenzothiazole (6), 2-amino-6-methylbenzothiazole (11), and 2-amino-6-methoxybenzothiazole (16), respectively, were synthesized by the method found in the literature. The architectures of the synthesized complex compounds (1-20) were postulated through the application of Atomic Absorption Spectroscopy (AAS). Furthermore, the antimicrobial activities of compounds 1–20 were tested against Candida albicans (antifungal activity) and Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis (antibacterial activity). The results were compared with those obtained using the control compounds Fluconazole and Ketoconazole (antifungal activity) and Vancomycin, Levofloxacin, Cefepime, and Chloramphenicol (antibacterial activity). As a result of activity studies, synthesized compounds show activity against bacteria and yeasts. The best activity results were observed compounds 6 and 10 in C. albicans yeast, compound 20 in S. aureus bacteria, compound 13 in E. faecalis bacteria, compounds 12, 13, 17, and 20 in B. subtilis bacteria, compounds 5 and 19 in P. aeruginosa bacteria, compounds 1, 4, 6, 9, 17, and 20 in E. coli bacteria, and compounds 5, 6, 8, 17, and 19 in in L. monocytogenes bacteria. In particular, compound 4 for E. Coli, 6, and 10 for C. albicans showed better activity than the control compounds.

Keywords

• 2-Aminobenzothiazole
• metal complex
• antibacterial activity
• antifungal activity

Supporting Institution

This study was prepared by the Kütahya Dumlupınar University Scientific Research Projects Committee using materials from project number 2022/03.

Project Number

2022–03

Ethical Statement

This study does not require ethics committee approval or any special permissions.

Thanks

We would like to thank the Kütahya Dumlupınar University Scientific Reserch Projects Committee for their contributions.

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