Predictive Factors For Severe And Critical Coronavirus Disease-19 In Young Adults

Year 2024, , 11 - 19, 31.03.2024

Aslı Vatan , Hüseyin Doğuş Okan Aylin Çalıca Utku Gökcen Gürkök Budak , Ertuğrul Güçlü , Elif Köse , Aziz Öğütlü , Oğuz Karabay

https://doi.org/10.31832/smj.1030208

Abstract

Purpose: Advanced age is associated with a poor prognosis in Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The present study investigated the predictive factors for disease severity in young adults.
Method: Our study is a descriptive cross-sectional study. A total of 399 patients with SARS-CoV-2 aged under 60 who had been hospitalized at our hospital were retrospectively evaluated. Patients were stratified into mild, moderate, severe, and critical groups according to their respiratory rate, SpO2, and PaO2/FiO2 levels. The relationship between the signs and symptoms on hospital admission and the disease severity was evaluated.
Results: The patients were classified as mild (n:112), moderate (n:192), severe and critical (n:95) according to disease severity. The mean age was 44. 43 of 399 patients were followed in the intensive care unit, and 17 patients died. According to the binary logistic regression analysis, advanced age, hypertension, dyspnea on admission, elevated CRP, decreased lymphocyte and eosinophil count, multiple bilateral ground glass appearances, and consolidation independently predicted the severity of the disease.
Conclusion: The signs and symptoms should be evaluated in detail also in young patients with SARS-CoV-2. If risk factors are detected, they should be monitored more closely to predict a poor prognosis..

Keywords

SARS-CoV-2, Young adult, Prognostic factors

Project Number

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Genç Erişkinlerde Şiddetli Ve Kritik Coronavirüs 19 Hastalığı Gelişimini Öngördüren Faktörler.

Abstract

Amaç: Coronavirus disease 2019 (COVID 19) seyrinde ileri yaş varlığı hastalığın kötü gidişi ile ilişkilidir. Biz bu çalışmada 60 yaş altı genç hastalarda hastalığın şiddetini öngördüren faktörleri göstermeyi amaçladık.
Gereç ve Yöntemler: Çalışmamızda mart – temmuz 2020 tarihleri arasında hastanemizde yatarak takip edilen COVID-19 tanılı 399 hasta retrospektif olarak değerlendirildi. Hastalara COVID-19 tanısı WHO güncel önerilerine göre konuldu. Hastaların hastaneye başvuru sırasındaki semptom ve bulguları ile hastalığın şiddeti arasındaki ilişki değerlendirildi.
Bulgular: Hastalığın şiddetine göre; hastaların 112 ’si hafif, 192 ‘si orta ve 95 ’i şiddetli ve kritik olarak değerlendirildi. Hastaların hepsi 60 yaş ve altında olup ortalama yaş 44’ dü. Binary logistic regression analizine göre ileri yaş, hipertansiyon varlığı, hastaneye başvuru anında nefes darlığı olması, CRP yüksekliği, lenfosit ve eozinofil düşüklüğü , akciğer tomografisinde multipl bilateral buzlu cam tutulumu ve konsolidasyon varlığının hastalık ağırlığını bağımsız olarak öngördürdüğü saptandı.
Sonuç: COVID-19 ile başvuran genç hastalarda da semptom ve bulgular ayrıntılı değerlendirilmeli ve
risk faktörleri saptanırsa kötü gidiş öngörülerek hastalar daha yakından takip edilmelidir

Keywords

SARS-CoV-2, Genç yetişkin, Prognostik faktörler

Supporting Institution

yok

Project Number

yok

Thanks

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