Palatogenez: Sekonder damak gelişiminde Sonic hedgehog (Shh) sinyalinin rolü

Abstract

Palatogenez, malfonksiyonları yeni doğanda en sık görülen embriyonik gelişimsel anomalilerden biri olan konjenital yarık damağa yol açan, karmaşık ve kusursuz olarak dengelenmiş bir süreçtir. Çok sayıda sinyal yolakları ve transkripsiyon faktörleri palatal çıkıntıların gelişimi ile ilişkilidir. Bu makalenin amacı, sekonder damak gelişiminde kritik rol oynayan en önemli sinyal yolaklarından biri olan Sonic hedgehog (Shh) sinyal yolağı hakkında derleme yapmaktır. Bu çalışma, sekonder damak gelişimi sırasında oluşan karşılıklı epitelyal-mezenkimal etkileşimlerde Hedgehog sinyal yolağı üyelerinin ekspresyon modellerini ve Shh sinyalinin rolünü genel olarak değerlendirmektedir.

Keywords

• Sonic hedgehog (Shh)
• Hedgehog sinyal yolağı
• palatal çıkıntılar
• epitelyal-mezenkimal etkileşim
• yarık damak
• hücre çoğalması

Palatogenesis: The role of Sonic hedgehog (Shh) signaling in the secondary palate development

Abstract

Palatogenesis is a complicated and precisely balanced process in which malfunctions induce congenital cleft palate, one of the most common embryonic developmental anomaly seen in newborns. Multiple signaling pathways and transcription factors have been implicated in palatal shelves development. The purpose of this article is to review one of the most important signaling pathways that plays a critical role in secondary palate development, namely Sonic hedgehog (Shh) signaling pathway. It includes an overview of the expression patterns of members of the Hedgehog signaling pathway and the role of Shh signaling in the reciprocal epithelial-mesenchymal interactions during secondary palate development.

Keywords

• Sonic hedgehog (Shh)
• Hedgehog signaling pathway
• palatal shelves
• epithelial-mesenchymal interaction
• cleft palate
• cell proliferation

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