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Birinci Trimester Ultrasonografi Bulgularından İntrakranial Saydamlık Ölçümünün Fetal Anomali ve Gebelik Komplikasyonlarını Öngörmedeki Etkinliğinin Araştırılması

Year 2022, , 384 - 389, 29.09.2022
https://doi.org/10.31832/smj.1138119

Abstract

Amaç: Biz bu çalışmamızda, Türk popülasyonunda 11-14. gebelik haftaları için IT ve BPD persantil değerleri oluşturmayı ve intrakranial saydamlık ölçümünün fetal anomali ve gebelik komplikasyonlarını öngörmedeki etkinliğini araştırmayı amaçladık.
Gereç ve Yöntemler: Çalışmamız retrospektif olarak Ocak 2022 - Nisan 2022 tarihleri arasında Tıp Fakültesi Perinatoloji polikliniğinde 535 hastanın verileri değerlendirilerek yapılmıştır. Gestasyonel yaş (GA), son adet tarihinin ilk gününden itibaren hesaplandı ve baş-popo uzunluğu (CRL) ölçülerek doğrulandı. CRL ölçümleri 45-84 mm arasında olan tekil gebelikler çalışmaya dahil edildi. Yapısal veya kromozom anomalisi olan, NT ≥3 mm olan, ultrasonografide spina bifida saptanan veya intrauterin ex fetüs saptanan gebelikler çalışma dışı bırakıldı.
Bulgular: 535 gebe hasta değerlendirilmiş, 15 ikiz gebelik, yapısal veya kromozomal anomalili fetüsler (dördü kistik higroma, ikisi down sendromlu, ikisi ensefalosel ve biri vertebral anomalili), intrauterin ex fetüs (n=2) , NT ölçümleri ≥ 3 mm olan (n=5) toplam 31 gebe çalışma dışı bırakıldı. Geriye kalan 504 gebe, CRL ölçümleri 45-54 mm, 55-64 mm, 65-74 mm ve 75-84 mm olacak şekilde gruplandırılarak; IT ve BPD'nin 5., 50. ve 95. persentil değerleri hesaplanmıştır. Ayrıca IT ve BPD'nin 5., 50. ve 95. persentil değerleri, gebelik haftaları 11-11 hafta 6 gün ,12-12 hafta 6 gün, 13-13 hafta 6 gün ve 14-14 hafta 2 gün olarak gruplandırılarak hesaplanmıştır.
Sonuç: İlk trimesterde BPD ve IT için belirlenen <5 ve >95 persentil değerlerinin mevcut popülasyonda açık spina bifida, anöploidi ve yapısal kraniyal anomalilerin taranmasında kullanılabilecek pratik yöntemler olabileceğini düşünmekteyiz.

References

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  • 2. Campbell J, Gilbert W, Nicolaides K, Campbell SJO, Gynecology. Ultrasound screening for spina bifida: cranial and cerebellar signs in a high-risk population. 1987;70(2):247-50.
  • 3. Sacco A, Simpson L, Deprest J, David ALJPD. A study to assess global availability of fetal surgery for myelomeningocele. 2018;38(13):1020-7.
  • 4. Becker R, Wegner RDJUiO, Obstetrics GTOJotISoUi, Gynecology. Detailed screening for fetal anomalies and cardiac defects at the 11–13‐week scan. 2006;27(6):613-8.
  • 5. Meller C, Aiello H, Otaño LJCsNS. Sonographic detection of open spina bifida in the first trimester: review of the literature. 2017;33(7):1101-6.
  • 6. Orlandi E, Rossi C, Perino A, Cucinella G, Orlandi FJTJoM-F, Medicine N. Prospective sonographic detection of spina bifida at 11–14 weeks and systematic literature review. 2016;29(14):2363-7.
  • 7. Kavalakis I, Souka AP, Pilalis A, Papastefanou I, Kassanos DJPD. Assessment of the posterior brain at 11–14 weeks for the prediction of open neural tube defects. 2012;32(12):1143-6.
  • 8. Scheier M, Lachmann R, Pětroš M, Nicolaides KJUio, gynecology. Three‐dimensional sonography of the posterior fossa in fetuses with open spina bifida at 11–13 weeks' gestation. 2011;38(6):625-9.
  • 9. Solt I, Acuna JG, Adeniji BA, Mirocha J, Kim MJ, Rotmensch SJJoUiM. First‐trimester visualization of the fourth ventricle in fetuses with and without spina bifida. 2011;30(12):1643-7.
  • 10. Chaoui R, Benoit B, Mitkowska‐Wozniak H, Heling K, Nicolaides KJUiO, Obstetrics GTOJotISoUi, et al. Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11–13‐week scan. 2009;34(3):249-52.
  • 11. Adiego B, Illescas T, Martinez‐Ten P, Bermejo C, Perez‐Pedregosa J, Wong AE, et al. Intracranial translucency at 11–13 weeks of gestation: prospective evaluation and reproducibility of measurements. 2012;32(3):259-63.
  • 12. Iliescu D, Comănescu A, Antsaklis P, Tudorache S, Ghiluşi M, Comănescu V, et al. Neuroimaging parameters in early open spina bifida detection. Further benefit in first trimester screening. 2011;52(3):809-17.
  • 13. Mangione R, Dhombres F, Lelong N, Amat S, Atoub F, Friszer S, et al. Screening for fetal spina bifida at the 11–13 week scan using three anatomical features of the posterior brain. 2013;42(4):416-20.
  • 14. Chaoui R, Benoit B, Heling K, Kagan K, Pietzsch V, Sarut Lopez A, et al. Prospective detection of open spina bifida at 11–13 weeks by assessing intracranial translucency and posterior brain. 2011;38(6):722-6.
  • 15. Garcia Posada R, Eixarch E, Sanz M, Puerto B, Figueras F, Borrell AJUiO, et al. Cisterna magna width at 11–13 weeks in the detection of posterior fossa anomalies. 2013;41(5):515-20.
  • 16. Fong K, Toi A, Okun N, Al Shami E, Menezes RJUio. Retrospective review of diagnostic performance of intracranial translucency in detection of open spina bifida at the 11–13 week scan. 2011;38(6):630-4.
  • 17. Volpe P, Contro E, Fanelli T, Muto B, Pilu G, Gentile MJUiO, et al. Appearance of fetal posterior fossa at 11–14 weeks in fetuses with Dandy–Walker malformation or chromosomal anomalies. 2016;47(6):720-5.
  • 18. Iuculano A, Zoppi MA, Piras A, Arras M, Monni GJTJoM-F, Medicine N. Brain stem/brain stem occipital bone ratio and the four-line view in nuchal translucency images of fetuses with open spina bifida. 2015;28(12):1428-31.
  • 19. Engels AC, Joyeux L, Brantner C, De Keersmaecker B, De Catte L, Baud D, et al. Sonographic detection of central nervous system defects in the first trimester of pregnancy. 2016;36(3):266-73.
  • 20. Peixoto AB, Caldas TM, Lasmar LA, Martins WP, Pares DB, Araujo Júnior EJTJoM-F, et al. Reference range for the fetal intracranial translucency measurement between 11 and 14+ 2 weeks of gestation in a Brazilian population. 2016;29(16):2588-91.
  • 21. Chen M, Chen H, Yang X, Wang HF, Yeung Leung T, Singh Sahota D, et al. Normal range of intracranial translucency (IT) assessed by three-dimensional ultrasound at 11+ 0 to 13+ 6 weeks in a Chinese population. 2012;25(5):489-92.
  • 22. Chen FC-K, Gerhardt J, Entezami M, Chaoui R, Henrich WJUidM-EJoU. Detection of spina bifida by first trimester screening–results of the prospective multicenter Berlin IT-Study. 2017;38(02):151-7.
  • 23. Papastefanou I, Souka A, Pilalis A, Panagopoulos P, Kassanos DJPd. Fetal intracranial translucency and cisterna magna at 11 to 14 weeks: reference ranges and correlation with chromosomal abnormalities. 2011;31(12):1189-92.
Year 2022, , 384 - 389, 29.09.2022
https://doi.org/10.31832/smj.1138119

Abstract

References

  • 1. Timbolschi D, Schaefer E, Monga B, Fattori D, Dott B, Favre R, et al. Neural tube defects: The experience of the registry of congenital malformations of Alsace, France, 1995-2009. 2015;37(1):6-17.
  • 2. Campbell J, Gilbert W, Nicolaides K, Campbell SJO, Gynecology. Ultrasound screening for spina bifida: cranial and cerebellar signs in a high-risk population. 1987;70(2):247-50.
  • 3. Sacco A, Simpson L, Deprest J, David ALJPD. A study to assess global availability of fetal surgery for myelomeningocele. 2018;38(13):1020-7.
  • 4. Becker R, Wegner RDJUiO, Obstetrics GTOJotISoUi, Gynecology. Detailed screening for fetal anomalies and cardiac defects at the 11–13‐week scan. 2006;27(6):613-8.
  • 5. Meller C, Aiello H, Otaño LJCsNS. Sonographic detection of open spina bifida in the first trimester: review of the literature. 2017;33(7):1101-6.
  • 6. Orlandi E, Rossi C, Perino A, Cucinella G, Orlandi FJTJoM-F, Medicine N. Prospective sonographic detection of spina bifida at 11–14 weeks and systematic literature review. 2016;29(14):2363-7.
  • 7. Kavalakis I, Souka AP, Pilalis A, Papastefanou I, Kassanos DJPD. Assessment of the posterior brain at 11–14 weeks for the prediction of open neural tube defects. 2012;32(12):1143-6.
  • 8. Scheier M, Lachmann R, Pětroš M, Nicolaides KJUio, gynecology. Three‐dimensional sonography of the posterior fossa in fetuses with open spina bifida at 11–13 weeks' gestation. 2011;38(6):625-9.
  • 9. Solt I, Acuna JG, Adeniji BA, Mirocha J, Kim MJ, Rotmensch SJJoUiM. First‐trimester visualization of the fourth ventricle in fetuses with and without spina bifida. 2011;30(12):1643-7.
  • 10. Chaoui R, Benoit B, Mitkowska‐Wozniak H, Heling K, Nicolaides KJUiO, Obstetrics GTOJotISoUi, et al. Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11–13‐week scan. 2009;34(3):249-52.
  • 11. Adiego B, Illescas T, Martinez‐Ten P, Bermejo C, Perez‐Pedregosa J, Wong AE, et al. Intracranial translucency at 11–13 weeks of gestation: prospective evaluation and reproducibility of measurements. 2012;32(3):259-63.
  • 12. Iliescu D, Comănescu A, Antsaklis P, Tudorache S, Ghiluşi M, Comănescu V, et al. Neuroimaging parameters in early open spina bifida detection. Further benefit in first trimester screening. 2011;52(3):809-17.
  • 13. Mangione R, Dhombres F, Lelong N, Amat S, Atoub F, Friszer S, et al. Screening for fetal spina bifida at the 11–13 week scan using three anatomical features of the posterior brain. 2013;42(4):416-20.
  • 14. Chaoui R, Benoit B, Heling K, Kagan K, Pietzsch V, Sarut Lopez A, et al. Prospective detection of open spina bifida at 11–13 weeks by assessing intracranial translucency and posterior brain. 2011;38(6):722-6.
  • 15. Garcia Posada R, Eixarch E, Sanz M, Puerto B, Figueras F, Borrell AJUiO, et al. Cisterna magna width at 11–13 weeks in the detection of posterior fossa anomalies. 2013;41(5):515-20.
  • 16. Fong K, Toi A, Okun N, Al Shami E, Menezes RJUio. Retrospective review of diagnostic performance of intracranial translucency in detection of open spina bifida at the 11–13 week scan. 2011;38(6):630-4.
  • 17. Volpe P, Contro E, Fanelli T, Muto B, Pilu G, Gentile MJUiO, et al. Appearance of fetal posterior fossa at 11–14 weeks in fetuses with Dandy–Walker malformation or chromosomal anomalies. 2016;47(6):720-5.
  • 18. Iuculano A, Zoppi MA, Piras A, Arras M, Monni GJTJoM-F, Medicine N. Brain stem/brain stem occipital bone ratio and the four-line view in nuchal translucency images of fetuses with open spina bifida. 2015;28(12):1428-31.
  • 19. Engels AC, Joyeux L, Brantner C, De Keersmaecker B, De Catte L, Baud D, et al. Sonographic detection of central nervous system defects in the first trimester of pregnancy. 2016;36(3):266-73.
  • 20. Peixoto AB, Caldas TM, Lasmar LA, Martins WP, Pares DB, Araujo Júnior EJTJoM-F, et al. Reference range for the fetal intracranial translucency measurement between 11 and 14+ 2 weeks of gestation in a Brazilian population. 2016;29(16):2588-91.
  • 21. Chen M, Chen H, Yang X, Wang HF, Yeung Leung T, Singh Sahota D, et al. Normal range of intracranial translucency (IT) assessed by three-dimensional ultrasound at 11+ 0 to 13+ 6 weeks in a Chinese population. 2012;25(5):489-92.
  • 22. Chen FC-K, Gerhardt J, Entezami M, Chaoui R, Henrich WJUidM-EJoU. Detection of spina bifida by first trimester screening–results of the prospective multicenter Berlin IT-Study. 2017;38(02):151-7.
  • 23. Papastefanou I, Souka A, Pilalis A, Panagopoulos P, Kassanos DJPd. Fetal intracranial translucency and cisterna magna at 11 to 14 weeks: reference ranges and correlation with chromosomal abnormalities. 2011;31(12):1189-92.
There are 23 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Gülşah Aynaoğlu Yıldız 0000-0002-3283-7783

Hasan Süt 0000-0003-0982-3356

Publication Date September 29, 2022
Submission Date June 30, 2022
Published in Issue Year 2022

Cite

AMA Aynaoğlu Yıldız G, Süt H. Birinci Trimester Ultrasonografi Bulgularından İntrakranial Saydamlık Ölçümünün Fetal Anomali ve Gebelik Komplikasyonlarını Öngörmedeki Etkinliğinin Araştırılması. Sakarya Tıp Dergisi. September 2022;12(3):384-389. doi:10.31832/smj.1138119

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