Gastrointestinal Stromal Tümörlerin Kliniko-patolojik ve Cerrahi Özellikleri: 13 yıllık 3.Basamak Merkezi Deneyimi ve Literatür Derlemesi

Year 2023, , 166 - 170, 16.03.2023

Emrah Akın , Ahmet Tarık Harmantepe , Zeynep Kahyaoğlu Akkaya , Necattin Fırat , Merve Yiğit , Recayi Capoglu , Fatih Altıntoprak

https://doi.org/10.31832/smj.1202151

Abstract

Amaç: Gastrointestinal stromal tümörler (GIST) sindirim sisteminin en sık görülen mezenkimal kaynaklı tümörleridir. Bu çalışmada cerrahi tedavi uygulanmış olan GIST hastalarının erken dönem cerrahi sonuçları sunulmaktadır.
Materyal-Metod: Sakarya Üniversitesi Eğitim Araştırma Hastanesi Genel Cerrahi Kliniğinde 2008-2021 tarihleri arasında opere edilen ve histopatolojik olarak GIST tanısı doğrulanan hastaların sonuçları retrospektif olarak incelendi. Hastalar demografik veriler, klinik-patolojik özellikleri ve erken dönem cerrahi sonuçları açılarından ayrıntılı olarak değerlendirildi.
Bulgular: Ameliyat edilen 55 hastanın E/K oranı 3/2, yaş ortalaması 57.82 yıl (45-81 yıl) idi. Karın ağrısı (37 hasta - %67.2) en sık başvuru şikayetiydi. Mide (37 hasta - %67.2) en sık etkilenen organdı. CD117 pozitifliği 53 hastada (%96.3) oranında görüldü ve Ulusal Sağlık Enstitüsü (NIH) kategorisine göre hastaların %56.6’sı yüksek risk sınıfı olarak kategorize edildi. 52 hastaya (%94.6) primer cerrahi rezeksiyon uygulandı. En sık açık ameliyat 40 hastada (%72,7) tercih edildi, çalışmanın son 6 yılı için ise açık/laparoskopi tercih edilme oranı 1/1 olarak belirlendi. Segmental rezeksiyon 29 hastayla (%52,7) açık veya laparoskopik en sık uygulanan rezeksiyon tipi idi. Tümör boyutları ortalama 7.03 cm (1-18 cm), ortalama hastanede yatış süresi 10.44 gün (5-45 gün) idi, enterokütan fistül gelişen bir hasta çalışma dışı bırakıldığında ise ortalama hastane yatış süresi 8.2 gün (5-19 gün) olarak belirlendi.
Sonuç: GIST, uygun endikasyonlarda açık veya laparoskopik teknikle primer tedavi şekli komplet cerrahi rezeksiyon olarak deneyimli kliniklerde kabul edilebilir komplikasyon oranlarıyla güvenle tedavi edilebilir.

Keywords

Gist;, Stromal tümör;, Segmental rezeksiyon;, Wedge rezeksiyon;

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