Evre 1-3 Kolon Kanserinde Radyolojik Tutulumun Lokalizasyonu ve Sağ Kalıma Etkisi

Year 2023, , 55 - 61, 16.03.2023

Özlem Özkul

https://doi.org/10.31832/smj.1210830

Abstract

Amaç: Kolon kanserinin tek bir hastalık olmadığı, sağ ve sol kolon kanserinin epidemiyolojik, klinikopatolojik ve prognostik açıdan farklılıklar gösterdiği çok sayıda çalışma ile desteklenmiştir. Biz de çalışmamızda iki grup arasındaki demografik, klinik, biyokimyasal ve inflamatuar belirteçleri ve genel sağ kalım verilerini karşılaştırarak literatüre katkıda bulunmayı amaçladık.
Gereç ve Yöntemler: Çalışmaya evre 1-3 kolon kanserli rezektabl 77 hasta dâhil edildi (% 58,40 erkek, % 41,60 kadın). Hastalar sağ ve sol kolon kanseri olarak iki gruba ayrıldı. Gruplar arasında yaş, cinsiyet, evre, lenf nodu sayısı, patolojik ve biyokimyasal parametreler ile inflamatuar belirteçler karşılaştırıldı.
Bulgular: Sağ kolon kanserinde total çıkarılan lenf nodu sayısı (p: 0,010) ve mikrosatellit instabilite (MSI) yüksek hasta sayısı (p:0,001) sol kolon kanserine göre anlamlı olarak daha yüksek bulundu. Sol kolon kanserinde ise nötrofil sayısı sağ kolon kanserine göre daha fazlaydı (p: 0,008).
Sonuç: Sağ kolon kanserinde MSI yüksek hasta sayısı sola göre daha fazlaydı. Total çıkarılan lenf nodu sayısı da sağ kolon kanserinde daha yüksekti. Bunun aksine nötrofil sayısı sol kolon kanserinde daha yüksek bulundu. Sağ kalım analizleri için daha uzun takip süresine ihtiyaç vardı.

Keywords

Evre, Kolon kanseri, mGPS, MSI, Sağ kalım

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