Obezitenin Medikal Tedavisinde Liraglutide Etkinliğinin Araştırılması

Year 2023, , 334 - 339, 30.09.2023

Mustafa Altınkaynak , Yağmur Göksoy Solak , Naci Şenkal , Yavuz Burak Tor , Timur Akpınar , Murat Kose

https://doi.org/10.31832/smj.1320355

Abstract

Amaç Glikagon benzeri peptit-1 (GLP-1) analoğu olan liraglutidin diyabetten bağımsız olarak obezite tedavisinde kullanımı onaylanmıştır. Çalışmamızda liraglutidin obezite tedavisinde etkinliğini araştırıldı.
Yöntem ve Gereçler 2018-2021 yılları arasında genel dahiliye polikliniğine başvuran fazla kilolu ve obez, 18 yaş üzeri hastaların dosyaları incelendi. Tıbbi beslenme tedavisi ve egzersiz programına ile liraglutide 3 mg/gün en az bir ay alan hastalar çalışmaya alındı. Hastalar liraglutide kullanım sürelerine göre ayrılarak vücut kitle indeksi (VKİ), ilaç etkinliği ve yan etkileri her ay değerlendirildi.
Bulgular Çalışmamıza 201 kadın ortalama 40,9±10,5 yaş 303 hasta alındı. Hastaların VKİ dağılımına bakıldığında 80 hasta (%26,4) aşırı kilolu, 128 hasta (%42,2) evre 1 obezite, 61 hasta (%20,1) evre 2 obesite, 34 hasta (%11,2) ise evre 3 obezite olarak değerlendirildi. Liraglutide tedavisini 233 hasta 1-4 ay, 59 hasta 5-8 ay ve 11 hasta ise ≥9 ay süre ile kullandı. Bu grupların ortalama ortalama yaşı sırasıyla 41,2±10,5; 39,8±10,9 ve 40,2±10,4 ortalama VKİ’si 34,3±2,4 kg/m2; 33,9±4,2 kg/m2 ve 39,5±5,1 kg/m2 saptandı. Ortalama kilo kaybı ise sırasıyla 6,4 kg; 12,5 kg ve 21 kg saptandı. Her üç grupta da başlangıç kilosuna göre anlamlı kilo kaybı gözlendi (p<0,001). Hastaların ilk bir ayda %5 kilo kaybı hedefine ulaşma oranı %46, ilk 2 ayda %86, ilk 3 ayda ise %90 saptandı. En sık görülen etki bulantıydı.
Sonuç Liraglutide fazla kilolu ve obez hastalarda diyet ve egzersizle kombine olarak verildiğinde özellikle 6 ay ve üzeri kullanımda %20’lere varan kilo kaybı sağlamaktadır. Obezite tedavisinde GLP-1 analoglarının kullanımına ait uzun vadeli diğer çalışmalar ile mortalite üzerine etkileri orta koymakta fayda vardır.

Keywords

Obezite, tedavi, liraglutid, Glikagon benzeri peptit-1 (GLP-1)

Supporting Institution

Yok

Project Number

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Thanks

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Investigation of the Effectiveness of Liraglutide in the Medical Treatment of Obesity

Abstract

Introduction This study investigated the efficacy and safety of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, in the treatment of obesity.
Materials and Methods The study enrolled 303 patients over 18 years of age with overweight or obesity (201 female, mean age 40.9 years). The records of patients admitted from the Internal Medicine Outpatient Clinic between 2018 and 2021 were retrospectively reviewed. Patients taking liraglutide (3 mg) daily in combination with diet and physical activity were included. Body mass index (BMI), drug efficacy, and side effects were evaluated once monthly.
Results Participants' BMI was evaluated; 80 of them were overweight, 128 of them were obese stage 1, 61 of them were obese stage 2, and 34 of them were obese stage 3. Patients were divided into 3 groups according to the duration of liraglutide intake (1-4 months for 233 patients, 5-8 months for 59 patients, and ≥ 9 months for 11 patients). Mean age was 41.2±10.5, 39.8±10.9, and 40.2±10.4; mean BMI was 34.3±2.4 kg/m2, 33.9±4.2 kg/m2, and 39.5±5.1 kg/m2; and mean weight loss was 6.4 kg, 12.5 kg, and 21 kg, respectively. All groups experienced significant weight loss compared with their baseline weight (p<0.001). The percentage of patients achieving weight loss goal was 46% at month 1, 86% at 2 months, and 90% at 3 months. In addition, the most common side effect was nausea.
Conclusion In combination with lifestyle modification, liraglutide was well tolerated and resulted in significant weight loss, especially using for more than 6 months.

Keywords

Obese, treatment, liraglutide, glucagon-like peptide-1 (GLP-1)

Project Number

Yok

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