Diagnostic Value of Serum Thiobarbituric Acid Reactive Substances Levels in Pediatric Acute Appendicitis

Year 2024, , 28 - 33, 31.03.2024

Gürkan Altuntaş , Mehmet Altuntaş , Mehtap Atak

https://doi.org/10.31832/smj.1351769

Abstract

Purpose: This study aims to show the diagnostic value of Serum Thiobarbituric Acid Reactive Substances in pediatric appendicitis.
Method: Eighty-five pediatric patients hospitalized in the pediatric surgery ward with acute appendicitis and a control group of 50 pediatric patients with unspecific abdominal pain were included in this prospective case-control study. Forty-five patients whose pathology specimens confirmed acute appendicitis made up the final appendicitis group.
Results: Patients with appendicitis had higher Serum Thiobarbituric Acid Reactive Substances (p<0.001) levels than the control group. In receiver operating characteristic analysis, areas under the curve were 0.654 for Serum Thiobarbituric Acid Reactive Substances.
Conclusion: Serum Thiobarbituric Acid Reactive Substances test of patients with appendicitis provides limited accuracy in the diagnosis of appendicitis.

Keywords

Appendicitis, Thiobarbituric Acid, TBARS, MDA, Oxidative stress, Pediatrics

Project Number

RTEU-TSA-2018-927

Pediatrik Akut Apandisitte Serum Tiyobarbitürik Asit Reaktif Madde Düzeylerinin Tanısal Değeri

Abstract

Amaç: Bu çalışma, pediatrik apandisitte Serum Tiyobarbitürik Asit Reaktif Maddelerinin tanısal değerini göstermeyi amaçlamaktadır.
Yöntem ve Gereçler: Bu prospektif vaka-kontrol çalışmasına, çocuk cerrahisi servisine akut apandisit nedeniyle yatırılan 85 pediatrik hasta ve spesifik olmayan karın ağrısı olan 50 pediatrik hastadan oluşan kontrol grubu dahil edildi. Patoloji örnekleri akut apandisiti doğrulayan 45 hasta son apandisit grubunu oluşturdu.
Bulgular: Apandisitli hastaların Serum Tiyobarbitürik Asit Reaktif Madde düzeyleri kontrol grubuna göre daha yüksekti (p<0,001). Alıcı çalışma karakteristiği analizinde, Serum Tiyobarbitürik Asit Reaktif Maddeleri için eğri altındaki alan 0,654 idi.
Sonuç: Apandisitli hastalarda serum Tiyobarbitürik Asit Reaktif Maddeler testi apandisit tanısında sınırlı doğruluk sağlamaktadır.

Keywords

Apandisit, Tiyobarbütirik asit, TBARS, MDA, Oksidatif Stres, Pediatri

Project Number

RTEU-TSA-2018-927

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