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Thicknesses of The Macula and Retinal Nerve Fiber Layer in Patients with Anisometropic Amblyopia

Year 2015, , 87 - 91, 07.09.2015
https://doi.org/10.5505/sakaryamj.2015.29981

Abstract

Objective: To compare macular and retinal nerve fiber layer thicknesses of the normal fellow eye to that of the amblyopic eye using optical coherence tomography in patients with anisometropic amblyopia.Methods and Material: 18 patients with anisometropic amblyopia were included. Patients were divided into two groups: nine hyperopic and nine myopic. Best corrected visual acuity, refraction, retinal nerve fiber layer and macular thicknesses were measured.Results: The mean macular thickness of all anisometropic patients was 195 (±20.8) µm and (171±45.8) µm, and the mean retinal nerve fiber layer thickness was 101.50 (±15.23) and 102.61 (±11.48), in the amblyopic eye and the normal eye, respectively. There was no significant difference between eyes in either macular or retinal nerve fiber layer thickness. Also there was no significant difference in two parameters in myopic and hyperopic group.Conclusions: No difference between the macular and retinal nerve fiber layer thicknesses was established in anisometropic amblyopia. Further evaluation is needed.

References

  • Caputo R, Frosini R, De LC, Campa L, Magro EF, Secci J. Factors influencing severity of and recovery from anisometropic amblyopia. Strabismus. 2007;15:209-214.
  • Holmes JM, Kraker RT, Beck RW, Birch EE, Cotter SA, Everett DF, et al. A randomized trial of prescribed patching regimens for treatment of severe amblyopia in children. Ophthalmology. 2003; 110: 2075-2087.
  • Holmes JM, Beck RW, Kraker RT, Cole SR, Repka MX, Birch EE, et al. Impact of patching and atropine treatment on the child and family in the amblyopia treatment study. Arch Ophthalmol. 2003; 121:1625-1632.
  • Baddini-Caramelli C, Hatanaka M, Polati M, Umino AT, Susanna R Jr. Thickness of the retinal nerve fiber layer in amblyopic and normal eyes: a scanning laser polarimetry study. J AAPOS 2001;5:82-4.
  • Wiesel TN, Hubel DH. Effects of visual deprivation on morphology and physiology of cells in cat’s lateral geniculate body. J Neurophysiol 1963; 26:978-93.
  • Von Noorden GK. Mechanism of amblyopia. Doc Ophthalmol 1977;34:93.
  • Headon MP, Powell TS. Cellular changes in the lateral geniculate nucleus of infant monkeys after suture of eyelids. J Anat 1973; 116:135-45.
  • Von Noorden GK. Histological studies of the visual system in monkeys with experimental amblyopia. Invest Ophthalmol Vis Sci 1973; 12: 727-38.
  • Colen TP, de Faber JT, Lemij HG. Retinal nerve fiber layer thickness in human strabismic amblyopia. Binocul Vis Strabismus Q 2000;15:141-6.
  • Altintas O, Yuksel N, Ozkan B, Caglar Y. Thickness of the retinal nerve fiber layer, macular thickness, and macular volume in patients with strabismic amblyopia. J Pediatr Ophthalmol Strabismus 2005;42:216-21.
  • Bozkurt B, Irkec M, Orhan M. Thickness of the retinal nerve fiber layer in patients with anisometropic and strabismic amblyopia. Strabismus Binocul Vis Strabismus Q 2003;11:1-7.
  • Yen MY, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci 2004;45:2224-30.
  • Yoon SW, Park WH, Baek SH, Kong SM. Thickness of macular retinal layer and peripapillary retinal nerve fiber layer in patients with hyperopic anisometropic amblyopia. Korean J Ophthalmol 2005;19:62-7.
  • Repka MX, Goldenberg-Cohen N, Edwards AR. Retinal nerve fiber layer thickness in amblyopic eyes. Am J Ophthalmol 2006;142:247-51.
  • Dickmann A, Petroni S, Salerni A, Dell’Omo R, Balestrazzi E. Unilateral amblyopia: An optical coherence tomography study. J AAPOS 2009;13:148-150.

Anizometrik ambliyopi hastalarının makula ve retina sinir lifi tabaka kalınlıkları

Year 2015, , 87 - 91, 07.09.2015
https://doi.org/10.5505/sakaryamj.2015.29981

Abstract

AMAÇ: Anizometropik ambliyopi hastalarının makula kalınlıklarının ve retina sinir lifi tabaka kalınlıklarının optik koherens tomografi ile ölçülen değerlerinin sağlam gözleri ile ambliyop gözleri arasında değerlendirilmesiGereç ve Yöntemler: Çalışmaya 18 anizometropik ambliyopi hastası dahil edildi ve hastalar 9 hiperopik ve 9 miyopik olmak üzere iki gruba ayrıldı. Hastaların tamamında en iyi düzeltilmiş görme keskinliği, refraktometrik değerleri,retina sinir lifi tabaka kalınlığı ve makula kalınlığı optik koherens tomografi cihazı ile ölçüldü. Çalışma türü prospektif olup istatistiksel analiz için SPSS 11.0 software programı kullanıldı.Bulgular: Ortalama makula kalınlığı ambliyop gözlerde 195 (±20.8) µm ve sağlam gözlerde 171(±45.8) µm ölçülmüş olup ortalama retina sinir lifi tabaka kalınlığı ambliyop gözlerde 101.50 (±15.23) ve sağlam gözlerde 101.50 (±15.23) ölçüldü. Sağlam gözler ve ambliyop gözlerin makula kalınlığı ve retina sinir lifi tabaka kalınlığı arasında istatistiksel olarak anlamlı bir fark bulunmadı. Ayrıca hiperopik grup ile miyopik grup arasında da istatsitiksel olarak anlamlı bir fark tespit edilmedi. Sonuç: Ambliyopi göz küresinde herhangi bir organik patoloji olmadan görme keskinliğinin yeteri kadar gelişmemesi durumudur.Biz çalışmamızda 18 anizometropik ambliyop hastasının makula kalınlıkları ve retina sinir lifi tabaka kalınlıklarını ambliyop ve sağlam gözlerde karşılaştırdık. Hastaların sağlam gözleri ile ambliyop gözleri arasında istatistiksel olarak anlamlı bir fark bulamadık ama bu konuda daha fazla bilimsel çalışmaların yapılması gerektiğini düşünüyoruz.

References

  • Caputo R, Frosini R, De LC, Campa L, Magro EF, Secci J. Factors influencing severity of and recovery from anisometropic amblyopia. Strabismus. 2007;15:209-214.
  • Holmes JM, Kraker RT, Beck RW, Birch EE, Cotter SA, Everett DF, et al. A randomized trial of prescribed patching regimens for treatment of severe amblyopia in children. Ophthalmology. 2003; 110: 2075-2087.
  • Holmes JM, Beck RW, Kraker RT, Cole SR, Repka MX, Birch EE, et al. Impact of patching and atropine treatment on the child and family in the amblyopia treatment study. Arch Ophthalmol. 2003; 121:1625-1632.
  • Baddini-Caramelli C, Hatanaka M, Polati M, Umino AT, Susanna R Jr. Thickness of the retinal nerve fiber layer in amblyopic and normal eyes: a scanning laser polarimetry study. J AAPOS 2001;5:82-4.
  • Wiesel TN, Hubel DH. Effects of visual deprivation on morphology and physiology of cells in cat’s lateral geniculate body. J Neurophysiol 1963; 26:978-93.
  • Von Noorden GK. Mechanism of amblyopia. Doc Ophthalmol 1977;34:93.
  • Headon MP, Powell TS. Cellular changes in the lateral geniculate nucleus of infant monkeys after suture of eyelids. J Anat 1973; 116:135-45.
  • Von Noorden GK. Histological studies of the visual system in monkeys with experimental amblyopia. Invest Ophthalmol Vis Sci 1973; 12: 727-38.
  • Colen TP, de Faber JT, Lemij HG. Retinal nerve fiber layer thickness in human strabismic amblyopia. Binocul Vis Strabismus Q 2000;15:141-6.
  • Altintas O, Yuksel N, Ozkan B, Caglar Y. Thickness of the retinal nerve fiber layer, macular thickness, and macular volume in patients with strabismic amblyopia. J Pediatr Ophthalmol Strabismus 2005;42:216-21.
  • Bozkurt B, Irkec M, Orhan M. Thickness of the retinal nerve fiber layer in patients with anisometropic and strabismic amblyopia. Strabismus Binocul Vis Strabismus Q 2003;11:1-7.
  • Yen MY, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci 2004;45:2224-30.
  • Yoon SW, Park WH, Baek SH, Kong SM. Thickness of macular retinal layer and peripapillary retinal nerve fiber layer in patients with hyperopic anisometropic amblyopia. Korean J Ophthalmol 2005;19:62-7.
  • Repka MX, Goldenberg-Cohen N, Edwards AR. Retinal nerve fiber layer thickness in amblyopic eyes. Am J Ophthalmol 2006;142:247-51.
  • Dickmann A, Petroni S, Salerni A, Dell’Omo R, Balestrazzi E. Unilateral amblyopia: An optical coherence tomography study. J AAPOS 2009;13:148-150.
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Selim Cevher

Nedime Şahinoğlu Keşkek This is me

Sezer Helvacı This is me

Ahmet Ergin This is me

Publication Date September 7, 2015
Submission Date September 7, 2015
Published in Issue Year 2015

Cite

AMA Cevher S, Keşkek NŞ, Helvacı S, Ergin A. Anizometrik ambliyopi hastalarının makula ve retina sinir lifi tabaka kalınlıkları. Sakarya Tıp Dergisi. June 2015;5(2):87-91. doi:10.5505/sakaryamj.2015.29981

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