Right-Sided Adenomas of the Colon: A Risk Factor For High-Grade Dysplasia or Invasive Cancer

Abstract

AIM: The aim of the study was to evaluate multiple patient and adenoma variables associated with high-grade dyplasia (HGD) and invasive carcinoma. (which were termed as "advanced pathology (AP)").MATERIALS AND METHODS: In total 6250 processes there were 1379 (22.06 %) polyps from 894 patients. We evaluated 914 polpys which we could find patholojical results.RESULTS: A total of 699 adenomas were detected from 914 polyps. We found more higher percantage of AP features at the rigt-sided adenomas than the left-sided (18.5% vs 7.1%, p: 0.002). According to the logistic regression analysis; male gender, larger or equal 2 cm diameter, villous histology and non-dimunitive gross appearance were found to be the independent risk factors for the AP features of the adenomas.CONCLUSION: In our study, similar to other studies, male gender, larger than 2 cm adenom diameter, villous component and non-dimunitive gross appearance are the independent risk factors for the AP features of any adenomas. However in contrast to most of the other studies we found higher percentage of AP features at the right-sided adenomas than the left-sided ones.

Keywords

• Colorectal adenomas, dysplasia, adenocarcinoma

Sağ Kolon Yerleşimli Adenomlar: High-Grade Displazi veya İnvaziv Kanser için Risk Faktörü

Abstract

Amaç: Bu çalışmanın amacı high-grade displazi (HGD) ve invaziv kanser ( “ilerlemiş patoloji (İP)” olarak tanımlanmıştır) ile ilişkili multipl hasta ve adenom karakterlerini değerlendirmektir. Materyal ve Metod: Toplam 6250 işlem sonunda 894 hastada 1379 (% 22.06) polip mevcuttur. Biz patoloji sonuçlarına ulaşabildiğimiz 914 polipi değerlendirmeye aldık. Bulgular: 914 polipte toplam 699 adenom tespit edildi. A total of 699 adenomas were detected from 914 polyps. Sağ kolon yerleşimli poliplerde sola göre daha yüksek oranda İP özellikleri bulundu (% 18.5 vs % 7.1 p: 0.002). Lojistik regresyon analizi sonucunda; erkek cinsiyet, 2 cm’e eşit ya da büyük boyut, villöz histoloji ve non-dimünitif görünüm adenomlardaki İP özellikleri için bağımsız risk faktörleri olarak bulundu. Sonuç: Çalışmamızda, diğer çalışmalara benzer olarak, erkek cinsiyet, 2 cm’e eşit ya da büyük boyut, villöz histoloji ve non-dimünitif görünüm adenomlardaki İP özellikleri için bağımsız risk faktörleri olarak bulundu. Fakat diğer birçok çalışmanın aksine biz sağ kolon yerleşimli poliplerde sol taraf yerleşimli poliplere göre daha yüksek oranda İP özellikleri bulduk.

Keywords

• Kolorektal adenomlar, dizplazi, adenokanser

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