Adenocarcinoma arising in adenomatous polyposis coli

Year 2014, , 191 - 194, 01.12.2014

Eyüp Murat Yılmaz Ferhat Özden

https://doi.org/10.5505/sakaryamj.2014.90692

Abstract

Familial adenomatous polyposis coli (FAP) is an inherited syndrome in which numerous polyps form mainly in colonic epithelium. Risk for cancer development gradually increases in such a condition if left untreated. Due to apparent symptoms such as rectal bleeding and abdominal pain, patients usually diagnosed at an early age. We report a FAP case with malignant transformation which is diagnosed at emergency department.

Keywords

Polyposis coli, carcinom, ileus

Adenomatöz polipozis koli zemininde gelişen adenokarsinom

Abstract

Familyal adenomatöz polipozi koli (FAP) özellikle kolon epitelinde çok sayıda polip oluşumuyla karakterize genetik geçişli bir sendromdur. Tedavi edilmediği takdirde kanser gelişme riski giderek artmaktadır. Rektal kanama ve karın ağrısı gibi aşikar semptomlardan dolayı hastalar genellikle erken tanı almaktadır. Biz burada acil serviste tanı konulmuş olan malign transformasyon göstermiş bir FAP olgusunu sunmaktayız.

Keywords

Polipozis koli, karsinom, ileus

References

• Büyükdoğan M. Kolorektal kanserde genetik ve etyolojik faktörler. Selçuk Tıp Derg 2009; 25 (3): 171-180.
• Nandakumar G, Morgan JA, Silverberg D, Steinhagen RM. Familial polyposis coli: clinical manifestations, evaluation, management and treatment. Mt Sinai J Med 2004; 71: 384-91.
• Cruz-Correa M, Giardiello FM. Diagnosis and management of hereditary colon cancer. Gastroenterol Clin North Am 2002; 31: 537-49.
• Contessini-Avesani E, Botti F, Negri C. Familial adenomatous polyposis. Surgical treatment: when and how. Tech Coloproctol 2004; 8: 309-14.
• Fotiadis C, Tsekouras DK, Antonakis P, et al. Gardner’s syndrome: A case report and rewiev of the literature. World Gastroenterol 2005; 11: 5408- 11.
• Kartheuser A, Stangherlin P, Brandt D, et al. Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited. Familial Cancer 2006; 5: 241-60.
• Ishikawa H. Chemoprevention of carcinogenesis in familial tumors. Int J Clin Oncol 2004; 9: 299-303.
• Giardiello FM, Yang VWW, Hylind LM. Primary chemoprevention of familial adenomatous polyposis with sulindac. N Eng J Med 2002; 346: 1054-9.