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Vulvar Basal Cell Carcinoma: A Rare Localization

Year 2014, , 213 - 216, 01.12.2014
https://doi.org/10.5505/sakaryamj.2014.73645

Abstract

Although basal cell carcinoma (BCC) is often seen in sun-exposed areas, rare atypical locations as vulva have been reported. Infections, chronic irritation, radiation and chronic arsenic exposure are considered in the etiology of vulvar BCC. A seventy-five year old female patient who is on follow ups for multiple facial and scalp BCCs that are treated with topical imiquimod and cryotherapy because the patient rejected surgical interventions, had vulvar ulcerated nodule which was diagnosed as BCC. This case of BCC was located in two different anatomical regions, without a history of exposure to triggers as arsenic or radiation, thus we considered a role of primary inoculation in the spread of BCC.

References

  • Gibson GE, Ahmet I. Perianal and genital basal cell carcinoma: a clinicopathologic review of 51 cases. J Am Acad Dermatol 2001;45:68-71.
  • Pisani C, Paggiali S, De Padova L, Andreassi A, Bilenchi R. Basal cell carcinoma of the vulva. J Eur Acad Dermatol Venereol 2006; 20(4):446- 448.
  • Giorgi V, Salvini C, Massi D, Raspollini MR, Carli P. Vulvar basal cell carcinoma: retrospective study and review of the literature. Gynecol Oncol 2005;97:192-194.
  • Piura B, Rabinovich A, Dgani R. Basal cell carcinoma of the vulva. J Surg Oncol 1999;70:172-176.
  • Barrett TL, Smith KJ, Hodge JJ, Butler R, Hall FW, Skelton HG. Immu- nohistochemical nuclear staining for p53, PCNA, and Ki-67 in different histologic variants of basal cell carcinoma. J Am Acad Dermatol 1997;37:430-437.
  • DiGiovanna JJ. Posttransplantation skin cancer: scope of the problem, management, and role for systemic retinoid chemoprevention. Transplant Proc 1998;30:2771-2778.
  • Benedet JL, Miller DM, Ehlen TG, Bertrand MA. Basal cell carcinoma of the vulva: clinical features and treatment results in 28 patients. Obstet Gynecol 1997;90:765-768.
  • Nehal KS, Levine VJ, Ashinoff R. Basal cell carcinoma of the genitalia. Dermatol Surg 1998;24:1361–1363.
  • Strickland PT, Craesia D, Kripke ML. Enhancement of two stage skin carcinogenesis by exposure of distant skin to UV radiation. J Natl Cancer Inst 1985;74:1129-1134.
  • Yenidunya MO, Yilmaz S, Askar I, Ercocen AR, Ozbek MR. Linear basal cell carcinoma. J Clin Derm 1998,1:8-10.
  • Feakins RM, Lowe DG. Basal cell carcinoma of the vulva: a clinicopathologic study of 45 cases. Int J Gynecol Pathol 1997;16:319-324.
  • Mateus C, Fortier- Beaulieu M, Lhomme C et al. Basal cell carcinoma of the vulva: 21 cases. Ann Dermatol Venereol 2001;128:11-15.
  • Mulayım N, Foster Silver D, Tolgay Ocal I, Babalola E. Vulvar basal cell carcinoma: two unusual presentations and review of the literature. Gynecol Oncol 2002; 85:532-537.

Vulvar Bazal Hücreli Karsinom: Nadir Bir Yerleşim

Year 2014, , 213 - 216, 01.12.2014
https://doi.org/10.5505/sakaryamj.2014.73645

Abstract

BBazal hücreli karsinom (BHK) sıklıkla güneşe maruz kalan yerlerde görülür ancak nadiren vulva gibi atipik lokalizasyonlarda da bildirilmiştir. Vulvar yerleşimde etyolojide özellikle enfeksiyonlar, kronik irritasyon, radyasyon ve kronik arsenik maruziyeti düşünülmüştür. Çok yavaş büyüyen bu tümörlerde uzak metastaz oldukça nadirdir. 75 yaşında yüz ve saçlı deride BHK'ları sebebiyle operasyonu kabul etmediği için kriyoterapi ve topikal imikimod kombinasyonu ile takip ettiğimiz kadın hastanın vulvada gelişen ülsere nodülü BHK ile uyumlu olarak geldi. Burada iki farklı anatomik bölgede, arsenik veya radyasyon gibi tetikleyicilere maruziyet öyküsü olmadan BHK lezyonlarının gelişmesi BHK yayılımında primer inokülasyonun rolü olabileceğini düşündürmüştür.

References

  • Gibson GE, Ahmet I. Perianal and genital basal cell carcinoma: a clinicopathologic review of 51 cases. J Am Acad Dermatol 2001;45:68-71.
  • Pisani C, Paggiali S, De Padova L, Andreassi A, Bilenchi R. Basal cell carcinoma of the vulva. J Eur Acad Dermatol Venereol 2006; 20(4):446- 448.
  • Giorgi V, Salvini C, Massi D, Raspollini MR, Carli P. Vulvar basal cell carcinoma: retrospective study and review of the literature. Gynecol Oncol 2005;97:192-194.
  • Piura B, Rabinovich A, Dgani R. Basal cell carcinoma of the vulva. J Surg Oncol 1999;70:172-176.
  • Barrett TL, Smith KJ, Hodge JJ, Butler R, Hall FW, Skelton HG. Immu- nohistochemical nuclear staining for p53, PCNA, and Ki-67 in different histologic variants of basal cell carcinoma. J Am Acad Dermatol 1997;37:430-437.
  • DiGiovanna JJ. Posttransplantation skin cancer: scope of the problem, management, and role for systemic retinoid chemoprevention. Transplant Proc 1998;30:2771-2778.
  • Benedet JL, Miller DM, Ehlen TG, Bertrand MA. Basal cell carcinoma of the vulva: clinical features and treatment results in 28 patients. Obstet Gynecol 1997;90:765-768.
  • Nehal KS, Levine VJ, Ashinoff R. Basal cell carcinoma of the genitalia. Dermatol Surg 1998;24:1361–1363.
  • Strickland PT, Craesia D, Kripke ML. Enhancement of two stage skin carcinogenesis by exposure of distant skin to UV radiation. J Natl Cancer Inst 1985;74:1129-1134.
  • Yenidunya MO, Yilmaz S, Askar I, Ercocen AR, Ozbek MR. Linear basal cell carcinoma. J Clin Derm 1998,1:8-10.
  • Feakins RM, Lowe DG. Basal cell carcinoma of the vulva: a clinicopathologic study of 45 cases. Int J Gynecol Pathol 1997;16:319-324.
  • Mateus C, Fortier- Beaulieu M, Lhomme C et al. Basal cell carcinoma of the vulva: 21 cases. Ann Dermatol Venereol 2001;128:11-15.
  • Mulayım N, Foster Silver D, Tolgay Ocal I, Babalola E. Vulvar basal cell carcinoma: two unusual presentations and review of the literature. Gynecol Oncol 2002; 85:532-537.
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Seval Doğruk Kaçar This is me

Pınar Özuğuz This is me

Bekir Serdar Ünlü This is me

Merve Demir This is me

Betül Demirciler Yavaş This is me

Publication Date December 1, 2014
Submission Date September 7, 2015
Published in Issue Year 2014

Cite

AMA Kaçar SD, Özuğuz P, Ünlü BS, Demir M, Yavaş BD. Vulvar Bazal Hücreli Karsinom: Nadir Bir Yerleşim. Sakarya Tıp Dergisi. December 2014;4(4):213-216. doi:10.5505/sakaryamj.2014.73645

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