The Effect in respiratory chain of CoQ10

Abstract

CoQ10 levels are known to decrease with aging. Maintaining healthful levels of CoQ10 is important for heart health. CoQ10 functions as an electron carrier in the mitochondrial respiratory chain as well as serves as an important intracellular antioxidant. Coenzyme Q10 is a fat-soluble compound primarily synthesized by the body and also consumed in the diet. CoQ10 is an essential element of food that can now be used medicinally to support the sick host in conditions where nutritional depletion and cellular dysfunction occur. Some chronic disease conditions (cancer, heart disease, etc.) are also thought to reduce the biosynthesis and increase the demand for CoQ10 in the body.

Keywords

• Food, repiratory chain, CoQ10.

CoQ10'nin solunum zincirindeki etkisi

Abstract

CoQ10 seviyesinin yaşlanmayla birlikte azaldığı bilinmektedir. Kalp sağlığı için CoQ10'nin seviyesi önemlidir. CoQ10 mitokondrial solunum zincirinde bir elektron taşıyıcısı olarak, bunu yanı sıra önemli bir hücre içi antioksidan olarak görev yapar. CoQ10 yağda çözünebilen bir bileşiktir ve öncelikli olarak vücut tarafından sentezlenir ve ayrıca diyetle alınabilir. CoQ10, hasta tedavisinde besleyici ve hücresel bozuklukların tedavisinde destekleyici olarak kullanılan yiyeceklerin elzem bir maddesidir. Bazı kronik hastalıklar vücudun ihtiyacı olan CoQ10'in azalması ve biyosentezinin düşmesi ile bağlantılıdır.

Keywords

• Yiyecek, solunum zinciri, CoQ10.

References

1. Dallner, G., Sindelar, P.J. (2000). Regulation of ubiquinone metabolism. Free Radic Biol Med. 29: 285-94.
2. Folkers, K., Langsjoen, Per H.,Willis, R., Richardson, P., Xia, L.,Ye C., Tamagawa, H. (1990). Lovastatin decreases coenzyme Q levels in humans. Proc. Natl. Acad Sci. Vol. 87, pp. 8931-8934.
3. Crane, FL. (2001). Biochemical functions of coenzyme Q10. J Am Coll Nutr. 20(6):591-598.
4. Madhuri, K., Pari, P. and Gopal, P. N. V. (2011). CoQ10 - An Essential Nutrient Of Nowdays Life, International Journal Of Research In Pharmacy And Chemistry, Ijrpc, 1(2).
5. Michael, B., Schachter, M.D. (1996). Coenzyme Q10. Schachter center for complemenary medicine.
6. Menke, T., Gille, G., Reber, F., Janetzky, B., Andler, W., Funk, R.H., Reichmann, H. (2003). Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors. 18(1-4):65-72.
7. Linda, K.K., Sergey, K., Igor, R., Anne-Cécile, V.B., Chandan, K.J., Paul, M., Michae, J.F., Rajindar, S.S. (2002). Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radical Biology and Medicine. Volume 33, Issue 5, Pages 627–638.
8. Juan, A., Crestanello, N.M., Doliba, N.M., Doliba, A.M., Babsky, K.N., Mary, D.O., Glenn, J.R.W. (2002). Effect of Coenzyme Q10 Supplementation on Mitochondrial Function after Myocardial Ischemia Reperfusion. Journal of Surgical ResearchVolume 102, Issue 2 , Pages 221-228.

9. Franklin, L., Rosenfeldt, S. P., Anthony, L., Philip, N., Michael, R., Ruchong, O., Silvana, M., William, L. and Donald, E. (2002). Coenzyme Q10 Protects the Aging Heart against Stress Studies in Rats, Human Tissues, and Patients. Ann. N.Y. Acad. Sci. 959: 355–359.
10. Beal, M. F., and Shults, C.W. (2003) Effects of Coenzyme Q10 in Huntington’s disease and early Parkinson’s disease. Biofactors 18, 153 – 161.
11. Folkers, K., Langsjoen, P. H., et al. (1988). Biochemical deficiencies of coenzyme Q10 in HIV-infection and the exploratory treatment. Biochemical and Biophysical Research Communications vol. 153, no. 2, pp 888-896.
12. Igor, P., Katja, Z., Janko, Z. (2010). "Coenzyme Q10 Contents in Foods and Fortification Strategies".Critical Reviews in Food Science and Nutrition 50 (4): 269–80.
13. Moreno, D.A., Ilic, N., Poulev, A., Raskin, I., (2006). Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters. Life Sci. 78, 2797–2803.