The Role of Serum Adiponectin Levels on Ischemic Stroke

Abstract

Purpose: Atherosclerosis is among the major factors in ischemic stroke. It has been set forth that in the presence of adiponectin, which is produced from adipose tissue and downgrades athesclerosis, and of atherosclerosis risk factors such as obesity, hypertension, diabetes, and hyperlipidaemia, serum levels decline. In this study, we aimed at examining the relation between the serum adiponectin value and level of consciousness in patients with ischemic stroke.Method: 17 patients with acute ischemic stroke, who applied within the 24 hours after stroke and who are above the age of 45, were involved in the study and compared to the 22 healthy control group of similar age. The levels of adiponectin were measured in the serum samples of the patients taken within the first 24-48th hours of the patients and their levels of consciousness were evaluated with Glasgow coma score.Results: While adiponectin level is 17.16 ± 0.9 microg/mL in healthy cases, 8.80 ± 0.7 microg/mL has been found in ischemic stroke group and the difference between them was statistically significant (p

Keywords

• Ischemic stroke, atherosclerosis, and adiponectin

Serum Adinopektin Düzeylerinin İskemik İnmedeki Rolü

Abstract

Amaç: Ateroskleroz, iskemik inmede majör risk faktörlerindendir. Yağ dokudan üretilen, aterosklerozu gerileten adiponektinin; obezite, hipertansiyon, diyabet, hiperlipidemi gibi ateroskleroz risk faktörlerinin varlığında serum düzeylerinin azaldığı ortaya konulmuştur. Bu çalışmada iskemik inmeli hastalarda serum adiponektin değerlerini ve şuur düzeyi ile olan ilgisini incelemeyi amaçladık.Gereç ve Yöntem: Çalışmaya inme sonrası ilk 24 saati içerisinde başvuran, 45 yaş üstü akut iskemik inmeli 17 hasta alındı ve benzer yaştaki 22 sağlıklı kontrol grubu ile karşılaştırıldı. Hastaların ilk 24-48. saatlerinde alınan serum örneklerinde adiponektin düzeyleri ölçüldü ve bilinç düzeyleri Glaskow koma skoru ile değerlendirildi. Sonuçlar: Sağlıklı olgularda adiponektin düzeyi 17.16 ± 0.9 microg/mL iken iskemik inme grubunda 8.80 ± 0.7 microg/mL tespit edildi ve aralarındaki fark istatistiksel olarak anlamlı idi (p

Keywords

• İskemik inme, ateroskleroz ve adiponektin

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