Attention deficit hyperactivity disorder associated with lissencephaly type I

Abstract

Attention deficit/hyperactivity disorder (ADHD) is is characterized with inattention, distractibility, restless, hyperactivity, impulsiveness and other deficits of executive function. In ADHD there is evidence of structural and functional differences in the brain. It is known that pschomotor retardation was seen clinically in migration anomalia. We are presenting a girl having migration anomalia and severe symptoms of ADHD.

Keywords

• Attention deficit/hyperactivity disorder, lissencephaly, MRI

Lizensefali Tip 1'in eşlik ettiği dikkat eksikliği ve hiperaktivite bozukluğu

Abstract

Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) dikkatsizlik, dikkat dağınıklığı, yerinde duramama,aşırı hareketlilik, dürtüsellik ile karakterizedir. DEHB'de beyinde yapısal ve fonksiyonel değişikliklerin olduğuna dair kanıtlar vardır. Migrasyon anomalisinde psikomotor retardasyonun var olduğu bilinmektedir. Bu yayında, migrasyon anomalisi ve ağır derecede DEHB bulguları olan bir kız çocuğu sunuldu.

Keywords

• Dikkat Eksikliği Hiperaktivite Bozukluğu, lizensefali, MRI

References

1. Spetie L, Arnold LE: Attention-Deficit/Hyperactivity Disorder; in: Andres M, Volkmar FR (eds): Lewis's Child and Adolescent Psychiatry: A Comprehensive Textbook 4th Edition. USA Lippincott Williams & Wilkins 2007, pp 431-454.
2. D. Stubbe, Attention-Deficit/Hyperactivity Disorder In: Child and Adolescent Psychiatry, K Cheng, K.M.Myers, Editors, Lippincott Williams & Wilkins, USA (2005).
3. Verloes A, Elmaleh M, Gonzales M, Laquerrière A, Gressens P: Genetic and clinical aspects of lissencephaly. Rev Neurol 2007;163(5):533-547.
4. Dobyns WB, Truwit CL: Lissencephaly and other malformations of cortical development: 1995 update, Neuropediatrics 1995;26(3):132-147.
5. Pavone L, Rizzo R, Dobyns WB:Clinical manifestations and evaluation of isolated lissencephaly, Childs Nerv Syst. 1993;9(7):387-390.
6. Byrd SE, Bohan TP, Osborn RE, Naidich TP: The CT and MR evaluation of lissencephaly, AJNR Am J Neuroradiol. 1988;9(5):923-927.
7. Castellanos FX, Lee PP, Sharp W, Jeffries NO, Greenstein DK, Clasen LS et al.: Developmental trajectories of brain volume abnormalities in children and adolescents with attention deficit hyperactivity disorder, JAMA 2002;288:1740-1748.
8. Carmona S, Vilarroya O, Bielsa A: Global and regional gray matter reductions in ADHD: A voxel-based morphometric study, Neurosci Lett. 2005;389(2):88-93.

9. Aicardi J: The agyria-pachygyria complex: A spectrum of cortical malformations, Brain Dev 1991;13:1-8.
10. Liang JS, Lee WT, Young C, Peng SS, Shen YZ: Agyria- pachygyria: clinical, neuroimaging, and neurophysiologic correlations, Pediatr Neurol. 2002;27(3) :171-176.