Mean Platelet Volume for the differential diagnosis of Familial Mediterranean Fever and Irritable Bowel Syndrome

Abstract

Objective: Familial Mediterranean Fever (FMF) is an hereditary, autoimmune, inflammatory disease characterized by recurrent attacks of fever and sterile polyserositis. İrritable bowel syndrome (IBS) where patients suffer from recurrent abdominal pain and change in the stool form is a functional disorder of the gastrointestinal tract. Differential diagnosis is important in both of these diseases which are common in our country. We aimed to search if mean platelet volume (MPV) which is reported to change in many inflammatory diseases can be used to differentiate these two conditions.Materials and methods: Thirtynine FMF, 28 IBS patients who admitted to the Gastroenterology Department of Cankiri State Hospital were enrolled to the study. Complete blood count were performed using Standard techniques in the core laboratory of our hospital. Hemoglobin, white blood cell and platelet count were measured in addition to mean platelet volume. Results: Median MPV values were 8.3 (6.7-13.1) fl in FMF patients and 8.6 (7.0-14.9) fl in IBS patients (p: 0.093).Conclusion: MPV cannot be used to differentiate IBS from FMF with the current results; however, our results are hypothesis generating and can be tested in larger trials.

Keywords

• Familial mediterranean fever, inflammatory bowel disease, mean platelet volume.

Ailesel Akdeniz Ateşi ve İrritabl Barsak Sendromunun ayırıcı tanısında Ortalama Platelet Hacminin rolü

Abstract

Amaç: Ailesel akdeniz ateşi (AAA), tekrarlayan ateş ve başlıca plevra, periton ve sinovyanın etkilendiği poliserozit atakları ile karakterize olan otoimmün bir hastalıktır. İrritable barsak sendromu (İBS) ise gastroenteroloji pratiğinde oldukça sık rastlanan fonksiyonel bir rahatsızlık olup tekrarlayan karın ağrıları ve dışkı alışkanlıklarında değişiklikler ile seyreder. Her iki hastalık toplumumuzda sık görülmekte ve tanılarında güçlükler yaşanmaktadır. Son yayınlarda inflamatuar hastalıklarda gösterdiği değişiklik ile gündemde olan ortalama platelet hacmi (OPH) nin bu iki hastalığın ayırıcı tanısında kullanılabilirliğini araştırmayı amaçladık.Materyal-metod: Çalışmaya Çankırı Devlet Hastanesi Gastroenteroloji departmanına başvuran 39 AAA, 28 İBS hastası dahil edildi. Tüm AAA hastaları Kolşisin tedavisi almaktaydı. Tüm katılımcıların tam kan sayımı standart metodlar ile hastanemiz merkez laboratuarında yapıldı. Hemoglobin, beyaz küre, platelet sayıları ve ortalama platelet hacmi ölçüldü.Sonuç: Ortanca OPH değerleri AAA hastalarında 8.3 (6.7-13.1) fl, İBS hastalarında 8.6 (7.0-14.9) fl saptanmış; ve gruplar arasında istatistiksel olarak anlamlı fark saptanamamıştır (p: 0.093).Yorum: OPH, Ailesel Akdeniz Anemisi ve İrritable Barsak Sendromu ayırıcı tanısında bugün ki veriler doğrultusunda kullanılamaz; ancak bu konuda daha geniş çaplı araştırmalara ışık tutması yönünden düşündürücüdür.

Keywords

• Ailesel Akdeniz Ateşi, İrritable Barsak Sendromu, Ortalama Platelet Hacmi.

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