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Pityriasiform Eruption Associated with İmatinib

Year 2017, , 1 - 1, 12.04.2017
https://doi.org/10.31832/smj.306330

Abstract

Imatinib is a chemotherapy drug which is known to be associated skin eruptions commonly. Maculopapular, erythematous eruptions, edema and especially peri-orbital edema are

the most common skin eruptions reported with imatinib. Pityriasiform eruptions, hypopigmentation, lichenoid reactions, pityriasis rosea, psoriasis, porphyria cutanea tarda, erythema

nodosum are other reactions seen with imatinib less commonly. A 57-year-old male patient presented to dermatology outpatient clinic with an itchy rash all over his body. He

was on medication with imatinib for gastrointestinal stromal tumor. He had round erythematous scaly plaques covering his body and extensor sides of all extremities. Histopathologic

examination of a biopsy sample revealed fi ndings compatible with pityriasis rosea. A diagnosis of pityriaisform eruption associated with imatinib was made. We aimed to present this

case for exhibiting a rather rare reported skin reaction with imatinib, which is known to be related with particular skin reactions commonly.

References

  • Referans1 Scheinfeld N. Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. J Drugs Dermatol. 2006 ;5(3):228-31.
  • Referans2 Basso FG, Boer CC, Correa ME, Torrezan M, Cintra ML, de Magalhaes MH, et al. Skin and oral lesions associated to imatinib mesylate therapy. Support Care Cancer 2009; 17: 45–48.
  • Referans3 Guilhot F. Indications for imatinib mesylate therapy and clinical management. The Oncologist 2004; 9: 271–281. Referans4 Feininger MW, O’Brien SG, Ford M. Practical management of patients with chronic myelid leukemia receiving imatinib. J Clin Oncol 2003; 21: 1637–1647.
  • Referans5 Heidary N, Naik H, Burgin S. Chemotherapeutic agents and the skin: an update. J Am Acad Dermatol 2008; 58: 545–570.

İmatinib Kullanımı Sonrası Ortaya Çıkan Pitriaziform Erupsiyon

Year 2017, , 1 - 1, 12.04.2017
https://doi.org/10.31832/smj.306330

Abstract

İmatinib,kutanöz yan etkilere sıklıkla yol açan bir kemoterapi ajanıdır. Kutanöz yan etki olarak en sık makülopapüler, eritematöz erupsiyonlar, ödem, özellikle peri orbital ödem

görülmektedir. Pitriaziform erupsiyonlar; hipopigmentasyon, likenoid reaksiyonlar, pitiriazis rosea, psoriasis, porfi riya kutanea tarda, eritema nodosum gibi döküntüler ise bu ilaca

bağlı daha seyrek görülen reaksiyonlardır. 57 yaşında erkek hasta gastrointestinal stromal tümör tanısıyla imatinib almaktayken tüm vücuduna yayılan kaşıntılı döküntüler nedeniyle

polikliniğimize başvurdu. Üst ve alt tüm ekstremitelerin ekstensör yüzlerinde ve gövdede yerleşmiş eritemli skuamlı oval plakları gözlenen hastanın lezyonlarının birinden alınan

biyopsi örneğinin histopatolojik bulguları pitiriyazis rosea ile uyumlu bulundu. Başka herhangi bir ilaç kullanımı öyküsü olmayan hastanın döküntülerine imatinibe bağlı pitiriaziform

erupsiyon tanısı koyuldu. Bu olguyu sık deri döküntüsüne neden olan bir ajan olan imatinibin nispeten nadir görülen bir deri reaksiyonu tipini sergilemesi nedeniyle sunmayı

amaçladık.

References

  • Referans1 Scheinfeld N. Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. J Drugs Dermatol. 2006 ;5(3):228-31.
  • Referans2 Basso FG, Boer CC, Correa ME, Torrezan M, Cintra ML, de Magalhaes MH, et al. Skin and oral lesions associated to imatinib mesylate therapy. Support Care Cancer 2009; 17: 45–48.
  • Referans3 Guilhot F. Indications for imatinib mesylate therapy and clinical management. The Oncologist 2004; 9: 271–281. Referans4 Feininger MW, O’Brien SG, Ford M. Practical management of patients with chronic myelid leukemia receiving imatinib. J Clin Oncol 2003; 21: 1637–1647.
  • Referans5 Heidary N, Naik H, Burgin S. Chemotherapeutic agents and the skin: an update. J Am Acad Dermatol 2008; 58: 545–570.
There are 4 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Bahar Sevimli Dikicier

Mahizer Yaldız This is me

Teoman Erdem This is me

Zeynep Kahyaoğlu This is me

Devrim Çabuk This is me

Publication Date April 12, 2017
Submission Date February 7, 2016
Published in Issue Year 2017

Cite

AMA Sevimli Dikicier B, Yaldız M, Erdem T, Kahyaoğlu Z, Çabuk D. İmatinib Kullanımı Sonrası Ortaya Çıkan Pitriaziform Erupsiyon. Sakarya Tıp Dergisi. April 2017;7(1):1-1. doi:10.31832/smj.306330

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