The Effect of Vitamin D Deficiency on Disease Activity, Physical Function, Health-Related Quality of Life and Psychiatric Status in Patients with Axial Spondyloarthritis

Year 2017, , 217 - 222, 04.01.2018

Gamze Kılıç

https://doi.org/10.31832/smj.367259

Abstract

Objective: IAxial spondyloarthritis (axSpA) is a heterogeneous group of inflammatory diseases characterized by predominant involvement of the axial skeleton. Vitamin D deficiency is not a
rare situation in the world. The aim of this study was to assess the relationship between vitamin D deficiency and disease activity measures, health related quality of life (QoL) and
other clinical characteristics in patients with axSpA.
Method: Disease activity, functions, mobility, QoL and pain were assessed by using questionnaires and blood samples was collected for vitamin D levels in patients with axSpA.
Results: A total 25patients with ankylosing spondylitis (AS) and 25 non-radiographic (nr) axSpA were included. Mean age of AS and nr-axSpA was similar. Forty four percent of patients with
axSpA had vitamin D deficiency. Mean vitamin D levels were significantly lower in patients with nr-axSpA than AS. Some disease activity measurements were higher in patients with
axSpA who had vitamin D deficiency.
Conclusion: Quality of life measures were similar between the groups. There were low negative relationships between vitamin D level and Bath Ankylosing Spondylitis Functional Index, Bath
Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Disease Activity Index

Keywords

Axial spondyloarthritis, vitamin D, physical function, disease activity

D Vitamini Eksikliğinin Aksiyel Spondiloartritli Hastalarda Hastalık Aktivitesi, Fiziksel Fonksiyonlar, Sağlıkla İlgili Yaşam Kalitesi ve Psikiyatrik Durum Üzerine Etkisi

Abstract

Amaç: Aksiyel spondiloartrit (aksSpA), aksiyel iskeletin
baskın tutulumu ile karakterize heterojen bir inflamatuvar hastalık grubudur. D
vitamini eksikliği dünyada ender bir durum değildir. Bu çalışmanın amacı, axSpA
hastalarında D vitamini eksikliği ile hastalık aktivitesi, sağlıkla ilişkili
yaşam kalitesi ve diğer klinik özellikler arasındaki ilişkiyi
değerlendirmektir.

Gereç ve
Yöntemler: Hastalık aktivitesi, fonksiyonlar, mobilite,
yaşam kalitesi ve ağrı çeşitli indekslerle değerlendirildi ve aksSpA'lı
hastalarda vitamin D düzeyleri için kan örnekleri toplandı.

Bulgular: Toplam 25 ankilozan spondilit (AS), 25 radyografik
olmayan (nr) aksSpA’lı hasta dâhil edildi. AS ve nr-aksSpA'lı hastaların yaş
ortalaması benzerdi. AksSpA’lı hastaların %44'ünde D vitamini eksikliği vardı.
Ortalama vitamin D düzeyleri, nr-aksSpA'lı hastalarda AS’li hastalardan anlamlı
olarak daha düşüktü. D vitamini eksikliği olan aksSpA’lı hastalarda bazı
hastalık aktivite ölçekleri daha yüksekti.

Sonuç:
Yaşam kalitesi ölçütleri gruplar arasında benzerdi. D vitamini düzeyi ile Bath Ankilozan
Spondilit Fonksiyonel İndeksi (BASFI), Bath Ankilozan Spondilit Metroloji
İndeksi (BASMI) ve Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI) arasında
düşük negatif ilişki vardı.

Keywords

Aksiyel spondiloartrit, D vitamini, fiziksel fonksiyon, hastalık aktivitesi

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