Xanthelasma Palpebrarum is Associated with Higher Levels of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio

Abstract

Background: According to many epidemiologic studies, Xanthelasma Palpebrarum (XP) is thought to be a determinant of an increased risk of atherosclerosis. Many studies have show that inflammation plays an important role in the progress of atherosclerosis. Platelet to lymphocyte ratio (PLR) and Neutrophil to lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with mortality and cardiac events in several cardiovascular diseases. We aimed to investigate the relationship between PLR, NLR and XP in this study.

Methods: Sixty-six  subjects with XP and age and sex matched 66 control subjects were enrolled in the present study. Patients with known atherosclerotic vascular diseases were excluded. Baseline characteristics such as presence of hypertension, diabetes mellitus, hyperlipidemia, cigarette smoking history, medications and hematological parameters were compared between the two groups.

Results: Subjects with XP had higher levels of total cholesterol (217±54 mg/dl vs. 197±41mg/dl, p=0.04), low density lipoprotein cholesterol  (143±45 mg/dl vs. 120±33 mg/dl, p=0.002), triglyceride levels (174±91 vs. 149±95, p=0.02), NLR (1.8±0.8 vs. 1.5±0.5, p=0.004) and PLR (117±35 vs. 100±29, p=0.004)  than those in control subjects.

Conclusion: In the present study we found that NLR and PLR levels, which are indicative of systemic inflammation and multiple adverse cardiovascular outcomes, were higher in the XP patients. This suggests that XP patients may need a close follow-up for cardiac risk factors. 

Keywords

• Xanthelasma,inflammation

Xanthelasma Palpebrarum Artmış Nötrofil/Lenfosit ve Platelet/Lenfosit Oranı ile İlişkilidir

Abstract

Giriş: Epidemiyolojik çalışmalarda, Xanthelasma Palpebrarum (XP) artmış ateroskleroz riskinin belirleyicisi olduğu görülmüştür. Birçok çalışma, inflamasyonun ateroskleroz gelişiminde önemli bir rol oynadığını göstermektedir. Trombosit / lenfosit oranı ve nötrofil / lenfosit oranı , çeşitli kardiyovasküler hastalıklarda mortalite ve kardiyak olaylarla ilişkili olan sistemik inflamasyonun bir işaretidir. Bu çalışmada, trombosit / lenfosit oranı ve nötrofil / lenfosit oranı ile XP arasındaki ilişkiyi araştırmayı amaçladık.

Metod: Çalışmaya 66 XP olan ve yaş, cinsiyet eşleştirilmiş 66 kontrol hasta alındı. Bilinen aterosklerotik vasküler hastalığı olanlar çalışma dışı bırakıldı. Her iki grupta hipertansiyon, diabetes mellitus, hiperlipidemi, sigara kullanımı öyküsü, medikal tedavi öyküsü ve hematolojik parametreler gibi temel özellikler karşılaştırıldı.

Sonuç: XP olan olguların total kolestrol seviyeleri (217 ± 54 mg / dl'a karşılık 197 ± 41 mg / dl, p = 0.04), düşük yoğunluklu lipoprotein kolesterol düzeyleri (143 ± 45 mg / dl'ye karşı 120 ± 33 mg / dl, p = 0.002), trigliserit düzeyleri (174 ± 91 karşı 149 ± 95, p = 0.02), nötrofil/lenfosit  (1.8 ± 0.8'e karşı 1.5 ± 0.5, p = 0.004) ve platelet/lenfosit (117 ± 35'e karşı 100 ± 29, p = 0.004) kontrol gruptan daha yüksekti.

Tartışma: Bu çalışmada, XP hastalarında sistemik inflamasyon ve istenmeyen kardiyovasküler sonuçların göstergesi olan nötrofil/lenfosit oranı ve platelet/lenfosit oranı düzeylerinin daha yüksek olduğunu bulduk. Bu, XP hastalarının kardiyak risk faktörleri için yakın izlem gerektirebileceğini göstermektedir.

 

Keywords

• Ksantelezma,inflamasyon

References

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