Case Report
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Ferula Communis (Çakşır Otu)’in Neden Olduğu Karaciğer Toksisitesi: Vaka Sunumu

Year 2018, , 674 - 677, 30.09.2018
https://doi.org/10.31832/smj.400248

Abstract

Doğada yetişen bitkiler yüzyıllardır çeşitli hastalıkların tedavisinde
kullanılmış, birçok ilacın hammaddesini oluşturmanın yanında birçoğu da yüksek
oranda zehirleyici özelliğe sahiptir. Ferula communis (çakşır otu) günümüzde şifalı
bitki olarak tedavi ve beslenme amaçlı tüketilmektedir. Metabolik korunmada
anahtar rol oynayan karaciğer; zehirlenmede en fazla etkilenen organdır. Bu
yazıda ferula communis tüketimi sonrası gelişen  toksik karaciğer hastalığı olgusu sunmaktayız.

References

  • Seif, Howida SA (2016) Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni-Suef University Journal of Basic and Applied Sciences 5: 134-146 Çavus B, Alagöz M, Aksöz Z, Cengiz H (2018) Hepatotoxicity due to the Consumption of a Plant Growing In Eastern Anatolia: A Case Report. Clin Med Case Rep 2: 108.
  • Akaberi M, Iranshahy M, Iranshahi M (2015) Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferulacommunis L. subsp. communis). Iran J Basic Med Sci 18: 1050-1062
  • Monti M, Pinotti M, Appendino G, Dallocchio F, Bellini T, et al. (2007) Characterization of anti-coagulant properties of prenylated coumarin ferulenol. Biochimica et Biophysica Acta 1770: 1437-1440.
  • Iranshahi M, Amin GR, Jalalizadeh H, Shafiee A. New germacrene derivative from Ferula persica Willd. var. Latisecta Chamberlian. Pharm Biol 2003; 41:431-433 G. Appendino, The toxins of Ferula communis L. In: L. Verrotta, Editor, Virtual activity, Real Pharmacology vol. I (1997), pp. 1–15.
  • Rubiolo P, Matteodo M, Riccio G, Ballero M, Christen P, Fleury-Souverain S, et al. Analytical discrimination of poisonous and nonpoisonous chemotypes of giant fennel (Ferula communis L.) through their biologically active and volatile fractions. J Agr Food Chem. 2006;54:7556–7563
  • Lamnaouer D (1999) Anticoagulant activity of coumarins from Ferulacommunis L. Therapie 6: 747-751.
  • Bocca C, Gabriel L, Bozzo F, Miglietta A. Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol. Planta Med. 2002;68:1135–1137.
Year 2018, , 674 - 677, 30.09.2018
https://doi.org/10.31832/smj.400248

Abstract

References

  • Seif, Howida SA (2016) Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni-Suef University Journal of Basic and Applied Sciences 5: 134-146 Çavus B, Alagöz M, Aksöz Z, Cengiz H (2018) Hepatotoxicity due to the Consumption of a Plant Growing In Eastern Anatolia: A Case Report. Clin Med Case Rep 2: 108.
  • Akaberi M, Iranshahy M, Iranshahi M (2015) Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferulacommunis L. subsp. communis). Iran J Basic Med Sci 18: 1050-1062
  • Monti M, Pinotti M, Appendino G, Dallocchio F, Bellini T, et al. (2007) Characterization of anti-coagulant properties of prenylated coumarin ferulenol. Biochimica et Biophysica Acta 1770: 1437-1440.
  • Iranshahi M, Amin GR, Jalalizadeh H, Shafiee A. New germacrene derivative from Ferula persica Willd. var. Latisecta Chamberlian. Pharm Biol 2003; 41:431-433 G. Appendino, The toxins of Ferula communis L. In: L. Verrotta, Editor, Virtual activity, Real Pharmacology vol. I (1997), pp. 1–15.
  • Rubiolo P, Matteodo M, Riccio G, Ballero M, Christen P, Fleury-Souverain S, et al. Analytical discrimination of poisonous and nonpoisonous chemotypes of giant fennel (Ferula communis L.) through their biologically active and volatile fractions. J Agr Food Chem. 2006;54:7556–7563
  • Lamnaouer D (1999) Anticoagulant activity of coumarins from Ferulacommunis L. Therapie 6: 747-751.
  • Bocca C, Gabriel L, Bozzo F, Miglietta A. Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol. Planta Med. 2002;68:1135–1137.
There are 7 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Erkut Etçioğlu

Fidan Ağca Özen This is me

Deniz Çekiç This is me

Bilal Toka This is me

Mukaddes Tozlu This is me

Ahmet Tarık Eminler This is me

Publication Date September 30, 2018
Submission Date March 1, 2018
Published in Issue Year 2018

Cite

AMA Etçioğlu E, Ağca Özen F, Çekiç D, Toka B, Tozlu M, Eminler AT. Ferula Communis (Çakşır Otu)’in Neden Olduğu Karaciğer Toksisitesi: Vaka Sunumu. Sakarya Tıp Dergisi. September 2018;8(3):674-677. doi:10.31832/smj.400248

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