Investigation of the Levels of Copper, Iron, Zinc, Selenium and Ratios of Cu/Se, Cu/Zn, Fe/Se, Fe/Zn in Patients with Hashimoto Thyroiditis

Year 2018, , 285 - 291, 29.06.2018

Fatma Behice Serinkan Cinemre , Nurten Bahtiyar Bahtiyar , Esra Ertan Sevgin Değirmencioğlu Nilgun Dilaveroğlu Ayse Erdogan Çakar , Hakan Cinemre , Birsen Aydemir

https://doi.org/10.31832/smj.424877

Cited By: 1

Abstract

Objective Our aim was to investigate relationship of serum selenium(Se), zinc(Zn), copper(Cu) and iron(Fe) levels and ratios of Cu/Se, Cu/Zn, Fe/Se
and Fe/Zn with etiopathogenesis of Hashimoto Thyroiditis (HT). ( Sakarya Med J, 2018, 8(2):285-291 ).
Materials and
Methods
Thirty-fi ve patients with HT and 28 healthy controls were included. Serum Se, Fe, Cu and Zn were measured by inductively coupled plasma
optical emission spectrometry (ICP-OES) and Cu/Se, Cu/Zn, Fe/Se and Fe/Zn ratios were calculated.
Results Serum selenium, iron, copper and zinc levels were signifi cantly decreased in HT patients group (p<0,001, p<0,001, p<0,05 and p<0,001,
respectively). However, Cu/Zn and Cu/Se ratios were signifi cantly increased in HT patients (p<0,05). In HT patients, there were positive
correlations between Cu and Cu/Zn; between Fe/Se and Cu/Se ratios; between Fe/Zn and Fe/Se ratios (p<0,01). In the same group, Fe
levels were also positively correlated with Fe/Se and Fe/Zn ratios (p<0,01). However, Se level was negatively correlated with Cu/Se and Fe/
Se ratios (p<0,01). Additionally, Zn was negatively correlated with Cu/Zn ratio (p<0,01).
Conclusion Our results showed that together with trace element levels and ratios were involved in HT etiopathogenesis. Details of mechanisms underlying the disease should be clarifi ed with further studies.

Keywords

Hashimoto Thyroiditis, Se, Zn, Cu, Fe, Cu/Se, Cu/Zn, Fe/Se, Fe/Zn

Hashimoto Tiroiditli Hastalarda Bakır, Demir, Çinko, Selenyum Düzeyleri ve Cu/Se, Cu/Zn, Fe/Se, Fe/Zn Oranlarının Araştırılması

Abstract

Amaç: Bu çalışmanın
amacı, Hashimoto tiroiditi (HT)
etiyopatogenezinde selenyum (Se) demir (Fe), çinko
(Zn) ve bakır (Cu) eser elementlerinin serum düzeylerindeki ve
oranlarındaki değişimlerinin belirlenmesi ve bu parametreler arasındaki olası ilişkinin
değerlendirilmesidir.

Gereç ve Yöntem: Çalışma
35 HT ve 28 sağlıklı birey ile gerçekleştirildi. Çalışmaya dahil edilen tüm
bireylere ait serum Se, Zn, Cu ve Fe düzeyleri indüktif
eşleşmiş plazma optik emisyon spektrofotometresi (ICP-OES, Thermo iCAP 6000) ile
ölçüldü.

Bulgular: Serum
Se, Fe, Cu ve Zn düzeylerinin HT grubunda kontrol grubuna göre anlamlı derecede
azaldığı saptandı (sırasıyla p<0,001,
p<0,001, p<0,05 ve p<0,001). Cu/Zn ve Cu/Se oranlarının HT grubunda arttığı görüldü.  Ayrıca, HT grubunda Cu düzeyleri ile Cu/Zn
oranı; Fe/Se ile Cu/Se oranları; Fe/Zn ile Fe/Se oranları; Fe düzeyleri ile
Fe/Se ve Fe/Zn oranları arasında pozitif
korelasyon olduğu belirlendi.  Se
düzeylerinin Cu/Se ve Fe/Se oranları ile negatif korelasyon gösterdi.  Zn düzeyleri de Cu/Zn oranı ile negatif
korelasyon göstermiştir.

Sonuç: Çalışmamızın sonuçları, eser element
düzeyleri ve oranlarının HT etiyopatogenezinde yer aldığını göstermektedir. Hastalığın altta yatan
mekanizmaları ile eser element ve oranlarının etkileşiminin aydınlatılması için
daha ileri çalışmalara ihtiyaç duyulmaktadır. 

Keywords

Hashimoto tiroiditi, Se, Zn, Cu, Fe, Cu/Se, Cu/Zn, Fe/Se

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