İnfantlarda Görülen Kalsiyum Yüksekliğinin D Vitamini ile İlişkisi

Year 2018, , 813 - 819, 30.12.2018

Abdullah Yazar , Fatma Şamlıoğlu Fatih Akın , Şükrü Arslan

https://doi.org/10.31832/smj.480860

Abstract

ÖZ

Amaç: Kalsiyum
yüksekliği saptanan infantlarda hiperkalsemi etiyolojisinde D vitaminin rolünün
araştırmak ve D vitamini
düzeyine etki eden faktörlerin belirlenmesidir.

Gereç ve Yöntemler: Çalışmamız Ocak-Aralık 2012 tarihleri
arasında Konya Eğitim ve
Araştırma Hastanesi Çocuk Sağlığı
ve Hastalıkları Kliniği’nde yatan kalsiyum yüksekliği (≥10mg/dl) bulunan 53
infantta gerçekleştirildi. İnfantlar Grup I (1- 6 ay) ve Grup II (7-12 ay)
olmak üzere iki gruba ayrıldı. Çalışmaya
alınan tüm bebeklerde başvuruda ve D vitamin kesildikten bir ay sonra serum kalsiyum, fosfor, alkalenfosfataz
(ALP), parathormon (PTH), 25(OH)D3 ve spot idrarda kalsiyum, kreatinin(ca/cr)
düzeyleri çalışıldı.

Bulgular: Hastaların
44’ü (%83) erkek, 9 ‘u (%17)  kız idi ve
yaş ortalaması 5,11±2,48 aydı. Sadece
anne sütü alan bebeklerde serum 25(OH)D3 düzeyi (41,48 ng/ml)ek gıda alanlara
göre daha yüksek saptandı. 400 IU/gün D vitamini preperatı kullanan 45
infant ile farklı doz  (800-1200 IU/gün)
kullanan 8 infant arasında kalsiyum, fosfor, ALP, PTH ve 25(OH)D3 düzeyleri
arasında anlamlı fark yoktu( p≥0,05). Hastaların D vitamini kesildikten sonraki
kontrollerinde 25(OH)D3
düzeyinde düşüş sağlanırken kalsiyum seviyesi aynı düzeyde seyretti. Ancak D
vitamini düşüklüğü olduğu dönemde PTH ve fosfor artışı saptandı. ALP değerleri
değişmedi. Hastaların başvuru anında ve kontrollerinde hiperkalsiüri tespit
edilmedi.

Sonuç Kalsiyum yüksekliği sıklıkla
rutin biyokimya tetkiklerinde tesadüfen fark edilen, yaygın olmayan bir
elektrolit bozukluğudur. Sebeplerinden biri de D vitamini kullanımı olmakla
beraber, çalışmamızda 1200
IU/gün ve altındaki vitamini alımının hiperkalsemi ve hiperkalsiüri ile
ilişkisinin olmadığı gösterildi.

Anahtar
Kelimeler: D vitamini, infant, kalsiyum

 

 

 

 

 

 

The
Relationship of Hypercalcemia and Vitamin D in Infants

ABSTRACT

Objective: To
investigate the role of vitamin D in the etiology of hypercalcemia in infants
with calcium elevation and to determine the factors affecting vitamin D levels.

Material and Methods: Our study
was carried out in 53 infants with high calcium levels  (≥10 mg / dl) who were hospitalized in the
pediatrics clinic of Konya Training and Research Hospital between in a one year
period. The
patients were divided into two groups as Group I (1- 6 months-old) and Group II
(7-12 months-old). Serum levels of calcium, phosphorus, alkalenephosphatase
(ALP), parathormone (PTH), 25 (OH) D3 and spot urine calcium and creatinine (ca
/ cr) levels were studied in all infants on admission and one month after
vitamin D supplementation was stopped.

Results: 44 (83%) of the patients were
male and 9 (17%) were female and the mean age was 5,11 ± 2,48 months. Serum 25
(OH) D3 levels (41.48 ng / ml) were significantly higher in infants who
received only breast milk. There were no significant
differences between 45 infants who received 400 IU / day vitamin D and 8
infants using different doses (800-1200 IU / day) in terms of calcium,
phosphorus, ALP, PTH and 25 (OH) D3 levels (p≥0.05). 25 (OH) D3
levels were decreased and calcium levels remained the same after vitamin D
supplementation was stopped. However, there was an increase in PTH and
phosphorus levels in the period when vitamin D levels were low. ALP levels
did not change. Hypercalciuria was not detected at the time of admission and
the follow-up period of the patients.

Conclusion: Calcium is
a non-widespread electrolyte disorder, which is coincidentally detected during
routine biochemical analysis. Although one of the reasons was the use of
vitamin D, it was shown in our study that vitamin D intake of 1200 IU / day and
below did not correlate with hypercalcaemia and hypercalciuria.

Keywords: vitamine D, infant, calcium

0000-0003-0733-3943

Keywords

D vitamini; infant; kalsiyum

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