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Anizometropik Ambliyopi Olgularında Retina Sinir Lifi Tabakası, Maküla Kalınlığı ve Gangliyon Hücre Kompleksinin Değerlendirilmesi

Year 2019, , 420 - 425, 16.09.2019
https://doi.org/10.31832/smj.522440

Abstract

Amaç: Anizometropiye
bağlı tek taraflı ambliyopisi bulunan olguların retina sinir lifi
tabakası (RSLT), maküla kalınlığı (MK) ve gangliyon hücre kompleksinin (GHK)
optik koherens tomografi (OKT) cihazı ile değerlendirilip, sonuçların sağlam
göz ve kontrol grubuyla karşılaştırılması.



 



Gereç ve Yöntemler: Çalışmaya tek gözde anizometropik ambliyopi tespit edilen 89 hastanın 89
ambliyop gözü, kontrol grubu olarakta hasta grubunun 89 sağlam gözü ve 31
sağlıklı kişinin 62 gözü çalışmaya dahil edildi.
Tüm
olguların detaylı oftalmolojik muayenesinin ardından OKT cihazı ile RSLT, MK ve
GHK değerleri ölçülerek istatistiksel olarak karşılaştırıldı, p<0,05 değeri
istatistiksel olarak anlamlı kabul edildi.



 



Bulgular: Çalışmaya
dahil edilen katılımcıların yaş ortalamaları ambliyopi hasta grubunda
13.19±6.28 yıl, kontrol grubunda ise 13.5±6.5 yıl idi. MK analizlerine
bakıldığında gruplar arasında anlamlı farklılık tespit edilmedi (p>0,05).
Olguların ortalama RSLT değerleri arasında gruplar istatistiksel olarak anlamlı
farklılık saptanamamışken; superior ve inferior kadran kalınlığı ambliyop
gözlerde kontrol grubuna göre anlamlı olarak yüksek bulundu (sırasıyla;
p=0.045, p=0.026). GHK değerlendirmesinde üst kadran kontrol grubunda hasta
grubuna göre anlamlı olarak daha inceydi (p=0,026).



 



Sonuç: MK değerinde ambliyopi olguları ile kontrol grubu arasında anlamlı fark
bulunmazken,  RSLT’de üst ve alt kadran
ile GHK üst kadran kalınlıkları hasta grubunda kontrol grubuna göre istatiksel
olarak anlamlı yüksek bulunmuştur.

References

  • 1. Holmes JM, Clarke MP. Amblyopia. Lancet. 2006;367:1343–51.
  • 2. Brémond-Gignac D, Copin H, Lapillonne A, Milazzo S. Visual development in infants: physiological and pathological mechanisms. Curr Opin Ophthalmol. 2011;22:1-8
  • 3. Chen W, Chen J, Huang J, Xu J, Zhang F, Lu F. Comparison of macular and retinal nerve fiber layer thickness in untreated and treated binocular amblyopia. Curr Eye Res. 2013;38(12):1248-1254.
  • 4. DeSantis D. Amblyopia. Pediatr Clin North Am. 2014;61:505–18.
  • 5. Noorden GK Von. Histological Studies of the visual sytem in monkeys with experimental amblyopia. Invest Ophthalmol Vis Sci. 1973;12(10);727-7386. Campos E. Amblyopia. Surv Ophthalmol. 1995;40:23–39.
  • 7. Yen M-Y, Cheng C-Y, Wang A-G. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci. 2004;45:2224–30.
  • 8. Photocoagulation For Diabetic Macular Edema: Early Treatment Diabetic Retinopathy Study Report Number 1 Early Treatment Diabetic Retinopathy Study Research Group. Arch Ophthalmol. 1985;103(12):1796-806.
  • 9. Szigeti A, Tátrai E, Szamosi A, Vargha P, Nagy ZZ, Németh J, et al. A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation. PLoS One. 2014;9.2:e88363
  • 10. Shimko JF. Binocular Vision and Ocular Motility Theory and Management of Strabismus. Am Orthopt J. 2001;51:161-2
  • 11. Chow KL. Failure to demonstrate changes in the visual system of monkeys kept in darkness or in colored lights. J Comp Neurol. 1955;102:597–606.
  • 12. Yazici AT, Malkoç I, Altunkaynak BZ, Erdoğan AR, Aydin MD, Dane S, et al. Number of axons in the right and left optic nerves of right-pawed and left-pawed rats: a stereologic study. Anal Quant Cytol Histol. 2009;31:177–83.
  • 13. Park JM, Choi YJ, Kim DH. The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT. J Korean Ophthalmol Soc. 2016;57:98–105.
  • 14. Cleland BG, Crewther DP, Crewther SG, Mitchell DE. Normality of spatial resolution of retinal ganglion cells in cats with strabismic amblyopia. J Physiol. 1982;326:235-49
  • 15. Firat PG, Ozsoy E, Demirel S, Cumurcu T, Gunduz A. Evaluation of peripapillary retinal nerve fiber layer, macula and ganglion cell thickness in amblyopia using spectral optical coherence tomography. Int J Ophthalmol. 2013;6(1):90–94.
  • 16. Çelik E, Dogan E, Çakir B, Alisan S, Aksoy N, Alagoz G. Ambliyopide Fotoreseptör Tabaka Bütünlügü, Retina Sinir Lifi Tabakasi, Merkezi Maküla ve Ganglion Hücre Kompleksi Kalinliginin Degerlendirilmesi. Ret-Vit 2015;23:149-153
  • 17. Kee S-Y, Lee S-Y, Lee Y-C. Thicknesses of the Fovea and Retinal Nerve Fiber Layer in Amblyopic and Normal Eyes in Children. Korean J Ophthalmol. 2006;20(3):177-81.
  • 18. Repka MX, Kraker RT, Tamkins SM, Suh DW, Sala NA, Beck RW. Retinal Nerve Fiber Layer Thickness in Amblyopic Eyes. Am J Ophthalmol. 2009;142(2):247-51.
  • 19. Soltani Moghaddam R, Medghalchi A, Alizadeh Y. Survey of Nerve Fiber Layer Thickness in Anisometropic and Strabismic Amblyopia. Acta Med Iran. 2017;55:24–8.
  • 20. Huynh SC, Samarawickrama C, Wang XY, Rochtchina E, Wong TY, Gole GA, et al. Macular and Nerve Fiber Layer Thickness in Amblyopia. The Sydney Childhood Eye Study. Ophthalmology. 2009;116(9):1604-9.
  • 21. Al-Haddad CE, Mollayess GM El, Mahfoud ZR, Jaafa DF, Bashshur ZF. Macular ultrastructural features in amblyopia using high-definition optical coherence tomography. Br J Ophthalmol. 2013;97(3):318-22.
  • 22. Yoon SW, Park WH, Baek S-H, Kong SM. Thicknesses of Macular Retinal Layer and Peripapillary Retinal Nerve Fiber Layer in Patients with Hyperopic Anisometropic Amblyopia. Korean J Ophthalmol. 2005;19(1):62-7.
Year 2019, , 420 - 425, 16.09.2019
https://doi.org/10.31832/smj.522440

Abstract

References

  • 1. Holmes JM, Clarke MP. Amblyopia. Lancet. 2006;367:1343–51.
  • 2. Brémond-Gignac D, Copin H, Lapillonne A, Milazzo S. Visual development in infants: physiological and pathological mechanisms. Curr Opin Ophthalmol. 2011;22:1-8
  • 3. Chen W, Chen J, Huang J, Xu J, Zhang F, Lu F. Comparison of macular and retinal nerve fiber layer thickness in untreated and treated binocular amblyopia. Curr Eye Res. 2013;38(12):1248-1254.
  • 4. DeSantis D. Amblyopia. Pediatr Clin North Am. 2014;61:505–18.
  • 5. Noorden GK Von. Histological Studies of the visual sytem in monkeys with experimental amblyopia. Invest Ophthalmol Vis Sci. 1973;12(10);727-7386. Campos E. Amblyopia. Surv Ophthalmol. 1995;40:23–39.
  • 7. Yen M-Y, Cheng C-Y, Wang A-G. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci. 2004;45:2224–30.
  • 8. Photocoagulation For Diabetic Macular Edema: Early Treatment Diabetic Retinopathy Study Report Number 1 Early Treatment Diabetic Retinopathy Study Research Group. Arch Ophthalmol. 1985;103(12):1796-806.
  • 9. Szigeti A, Tátrai E, Szamosi A, Vargha P, Nagy ZZ, Németh J, et al. A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation. PLoS One. 2014;9.2:e88363
  • 10. Shimko JF. Binocular Vision and Ocular Motility Theory and Management of Strabismus. Am Orthopt J. 2001;51:161-2
  • 11. Chow KL. Failure to demonstrate changes in the visual system of monkeys kept in darkness or in colored lights. J Comp Neurol. 1955;102:597–606.
  • 12. Yazici AT, Malkoç I, Altunkaynak BZ, Erdoğan AR, Aydin MD, Dane S, et al. Number of axons in the right and left optic nerves of right-pawed and left-pawed rats: a stereologic study. Anal Quant Cytol Histol. 2009;31:177–83.
  • 13. Park JM, Choi YJ, Kim DH. The Analysis of Peripapillary RNFL, Macula and Macular Ganglion Cell Layer Thickness in Patients with Monocular Amblyopia Using SD-OCT. J Korean Ophthalmol Soc. 2016;57:98–105.
  • 14. Cleland BG, Crewther DP, Crewther SG, Mitchell DE. Normality of spatial resolution of retinal ganglion cells in cats with strabismic amblyopia. J Physiol. 1982;326:235-49
  • 15. Firat PG, Ozsoy E, Demirel S, Cumurcu T, Gunduz A. Evaluation of peripapillary retinal nerve fiber layer, macula and ganglion cell thickness in amblyopia using spectral optical coherence tomography. Int J Ophthalmol. 2013;6(1):90–94.
  • 16. Çelik E, Dogan E, Çakir B, Alisan S, Aksoy N, Alagoz G. Ambliyopide Fotoreseptör Tabaka Bütünlügü, Retina Sinir Lifi Tabakasi, Merkezi Maküla ve Ganglion Hücre Kompleksi Kalinliginin Degerlendirilmesi. Ret-Vit 2015;23:149-153
  • 17. Kee S-Y, Lee S-Y, Lee Y-C. Thicknesses of the Fovea and Retinal Nerve Fiber Layer in Amblyopic and Normal Eyes in Children. Korean J Ophthalmol. 2006;20(3):177-81.
  • 18. Repka MX, Kraker RT, Tamkins SM, Suh DW, Sala NA, Beck RW. Retinal Nerve Fiber Layer Thickness in Amblyopic Eyes. Am J Ophthalmol. 2009;142(2):247-51.
  • 19. Soltani Moghaddam R, Medghalchi A, Alizadeh Y. Survey of Nerve Fiber Layer Thickness in Anisometropic and Strabismic Amblyopia. Acta Med Iran. 2017;55:24–8.
  • 20. Huynh SC, Samarawickrama C, Wang XY, Rochtchina E, Wong TY, Gole GA, et al. Macular and Nerve Fiber Layer Thickness in Amblyopia. The Sydney Childhood Eye Study. Ophthalmology. 2009;116(9):1604-9.
  • 21. Al-Haddad CE, Mollayess GM El, Mahfoud ZR, Jaafa DF, Bashshur ZF. Macular ultrastructural features in amblyopia using high-definition optical coherence tomography. Br J Ophthalmol. 2013;97(3):318-22.
  • 22. Yoon SW, Park WH, Baek S-H, Kong SM. Thicknesses of Macular Retinal Layer and Peripapillary Retinal Nerve Fiber Layer in Patients with Hyperopic Anisometropic Amblyopia. Korean J Ophthalmol. 2005;19(1):62-7.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Turgay Uçak

Nurdan Gamze Taşlı This is me

Erdinç Bozkurt This is me

Erel İçel This is me

Yücel Karakurt This is me

Sümeyye Burcu Ağcayazı This is me

Mahmut Atum

Publication Date September 16, 2019
Submission Date February 5, 2019
Published in Issue Year 2019

Cite

AMA Uçak T, Taşlı NG, Bozkurt E, İçel E, Karakurt Y, Ağcayazı SB, Atum M. Anizometropik Ambliyopi Olgularında Retina Sinir Lifi Tabakası, Maküla Kalınlığı ve Gangliyon Hücre Kompleksinin Değerlendirilmesi. Sakarya Tıp Dergisi. September 2019;9(3):420-425. doi:10.31832/smj.522440

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