Stabil Koroner Arter Rahatsızlığı Olan Hastalarda Erken Repolarizasyon Patern Varlığı ile Koroner Arter Hastalığının Ciddiyeti Arasındaki İlişki

Abstract

Amaç: Erken repolarizasyon paterni (ERP) iyi huylu bir varyant olarak kabul edilmesine rağmen, son zamanlarda yapılan çalışmalarda hayatı tehdit eden aritmilerle ilişkili olduğu gösterilmiştir. Hayatı tehdit eden aritmi ve koroner arter hastalığının (KAH) şiddeti arasında güçlü bir ilişki olduğunu gösteren farklı çalışmalar vardır. Bu çalışmada ERP'li hastalarda Gensini skoru (GS) değerlerinin ERP'siz hastalara göre daha yüksek olup olmadığını belirlemeyi amaçladık.

Gereç ve Yöntemler: Çalışmaya ERP'li toplam 110 hasta ve 90 kontrol grubu alındı. Her hasta için GS hesaplandı. p< 0.05 anlamlı kabul edildi.

Bulgular: GS, ERP’li hastalarda kontrol grubuna göre anlamlı derecede yüksekti (19.5±20.2 ve 2.15±4.1; p <0.001). GS ile yaş arasında anlamlı ilişki vardı (r= 0.507, p< 0.001). GS, çok değişkenli lojistik regresyon analizinde bağımsız bir ERP belirleyicisidir (OR= 0.655,% 95 CI= 0.557-0.769, p <0.001). Ek olarak, yaş ve düşük yoğunluklu lipoprotein kolesterolü, lineer regresyon analizinde GS ile ilişkili bağımsız öngörücülerdi (OR= 0.370,%95 CI= 0.085-0.655, p= 0.011 ve OR= -0.094,%95 CI= (-0.176 -0.013), sırasıyla p= 0.024).

Sonuçlar: KAH'nın ciddiyetindeki artış, ERP'nin ortaya çıkmasına yol açan bir mekanizma olarak gösterilebilir.

Keywords

• Erken repolarizasyon patern; Gensini skoru; Stabil Koroner Arter Hastalığı

The Relationship Between the Presence of Early Repolarization Pattern and the Severity of Coronary Artery Disease in Patients with Stable Coronary Artery Disease

Abstract

Objective: Although early repolarization pattern (ERP) has been recognized as a benign variant, in recent studies have shown that it is associated with life-threatening arrhythmias. There are different studies demonstrated that there is a strong relationship between life-threatening arrhythmias and the severity of coronary artery disease (CAD). In this study, we aimed to determine whether Gensini score (GS) values were higher in patients with ERP compared to patients without ERP.

Materials and Methods: Totally 110 patients with ERP and 90 control subjects were enrolled to the study. GS was calculated for each patient. p values < 0.05 were considered significant.

Results: GS was significantly higher in the ERP patients compared with the control group (19.5±20.2 vs 2.15±4.1; p<0.001). There was significant correlation between GS and age (r=0.507, p<0.001). GS was an independent predictor of ERP in multivariate logistic regression analysis (OR=0.655, 95% CI=0.557-0.769, p<0.001). In addition to, age and low-density lipoprotein cholesterol were independent predictors associated with GS in linear regression analysis (OR=0.370, 95% CI=0.085-0.655, p=0.011 and OR= -0.094, 95% CI= (-0.176-0.013), p=0.024, respectively).

Conclusions: An increase in the severity of CAD may be shown as a mechanism that leads to the emergence of ERP.

Keywords

• Early repolarization pattern; Gensini score; Stable Coronary Artery Disease

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