Mean Platelet Volume and Coronary Artery Ectasia

Abstract

 

Abstract

Objective: Coronary artery ectasia (CAE) are defined as the dilation of a segment of a coronary artery at least 1.5 times the adjacent segment. Several studies have shown the association between mean platelet volume (MPV) and cardiovascular diseases. But the results are different. For this reason, we aimed to investigate the association of MPV with CAE.

Materials and Methods: 90 patients with normal coronary arteries and 70 patients with CAE were included. Routine blood and biochemical parameters were measured before the arteriography. Differences between groups for continuous variables were analyzed with t- test or Mann-Whitney U test. P values < 0.05 were considered significant.

Results: Baseline patient demographics, including age and clinical risk factors, were similar between the groups. Compared to the control group, MPV levels were significantly lower in the CAE group (8.84 ± 1.71fL vs. 10.43 ± 1.34, p < 0.001). MPV level of < 9,5 fL showed sensitivity , specificity value of 95%, 80%; area under the curve= 0.943, 95% CI, 0.906–0.980) for the prediction of CAE.

Conclusion: The present study suggests that MPV may decrease in patients with CAE.

Keywords

• Angiography,Coronary Aneurysms,Coronary Artery Disesas,Mean Platelet Volume.

Koroner Arter Ektazisinde Ortalama Trombosit Hacmi Düşüktür!

Abstract

Özet

Amaç: Koroner arter ektazi (KAE), bir koroner arterin bir segmentinin bitişiğindeki segmente göre  en az 1.5 katı genişlemesi olarak tanımlanır. Birçok çalışma, ortalama trombosit hacmi (OTH) ile kardiyovasküler hastalıklar arasındaki ilişkiyi göstermiştir. Ancak çalışmaların sonuçları farklı olup kafa karıştırıcıdır. Bu nedenle OTH ile KAE ilişkisini araştırmayı amaçladık.

Gereç ve yöntemler: Koroner arterleri normal 90 hasta ve KAE' li 70 hasta çalışmaya dahil edildi. Anjiyografiden  önce rutin kan ve biyokimyasal parametreler çalışıldı. Sürekli değişkenler için gruplar arasındaki farklar t-testi veya Mann-Whitney U testi ile analiz edildi. P <0,05 değerleri anlamlı kabul edildi.

Bulgular: Hastaların başlıca yaş ve klinik risk faktörlerini içeren ​​demografik verileri gruplar arasında benzerdi. Kontrol grubuyla karşılaştırıldığında, OTH düzeyleri KAE grubunda anlamlı olarak düşüktü (8.84 ± 1.71fL ve 10.43 ± 1.34, p <0.001).  MPV seviyesi <9,5 fL iken KAE tahmini için  duyarlılık ve  özgüllük değerleri sırasıyla % 95,% 80; eğri altında kalan alan = 0,943, % 95 CI, 0.906–0.980) olarak bulundu.

Sonuç:  Bu çalışma KAE' li hastalarda OTH' nin düşebileceğini düşündürmektedir.

Keywords

• Anjiyografi,Koroner arter hastalığı,Ortalama trombosit hacmi,Koroner anevrizma,Koroner arter hastalığı

References

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