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Mean Platelet Volume and Coronary Artery Ectasia

Year 2020, , 225 - 230, 15.06.2020
https://doi.org/10.31832/smj.696747

Abstract

 



Abstract



Objective:
C
oronary artery ectasia (CAE) are defined as
the dilation of a segment of a coronary artery at least 1.5 times the adjacent
segment.
Several studies have shown the association between
mean platelet volume (MPV) and cardiovascular diseases.
But
the results are different. For this
reason, we aimed to investigate the association of MPV with CAE.



Materials
and Methods:
90 patients with normal
coronary arteries and 70 patients with CAE were included. Routine blood and
biochemical parameters were measured before the arteriography. Differences
between groups for continuous variables were analyzed with t- test or
Mann-Whitney U test. P values < 0.05 were considered significant.



Results: Baseline patient demographics, including age and
clinical risk factors, were similar between the groups. Compared to the control
group, MPV levels were significantly lower in the CAE group (8.84 ± 1.71fL vs.
10.43 ± 1.34, p < 0.001). MPV level of < 9,5 fL showed sensitivity ,
specificity value of 95%, 80%;
area under the curve= 0.943, 95% CI, 0.906–0.980) for the
prediction of CAE.



Conclusion: The present study suggests that MPV may decrease in
patients with CAE.

References

  • References 1. Hartnell GG, Parnell BM, Pridie RB, Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients.Br Heart J 1985;54:392-397.
  • 2. Yamanaka O, Hobbs RE. Coronary artery anomalies in 126.595 patients undergoing coronary arteriography. Cather Cardiovasc Diagn 1990;21:28-40.
  • 3. Pinar Bermúdez E, López Palop R, Lozano Martínez-Luengas I, Cortés Sánchez R, Carrillo Sáez P, Rodríguez Carreras R, et al. Coronary ectasia: Prevalence, and cilinical and angiographic characteristics. Rev Esp Cardiol 2003;56:473-482.
  • 4. Daoud AS, Pankin D, Tulgan H, Florentin RA. Aneurysms of the coronary artery. Report of ten cases and review of literature. Am J Cardiol 1963;11:228-237.
  • 5. Sharma SN, Kaul U, Sharma S, Wasir HS, Manchanda SC, Bahl VK, et al. Coronary arteriographic profile in young and old Indian patients with ischemic heart disease: A comparative study. Indian Heart J 1990;42:365-374.
  • 6. Befeler B, Embi A, Mullin FL, Aranda MJ,El-Sherif N, Lazzara R. Coronary artery aneurysms: Study of the etiology, clinical course and effecton left ventricular function and prognosis. Am J Med 1977; 62:597-607.
  • 7. Sezer M, Okcular I, Goren T, Oflaz H, Nisanci Y, Umman B, et al. Association of haematological indices with the degree of microvascular injury in patients with acute anterior wall myocardial infarction treated with primary percutaneous coronary intervention. Heart 2007;93:313–318.
  • 8. Aboeata AS, Sontineni SP, Alla VM, Esterbrooks DJ. Coronary artery ectasia: current concepts and interventions. Front. Biosci. (Elite Ed.) 2012;4:300–310.
  • 9. Sayin T, Döven O, Berkalp B, Akyürek O, Güleç S, Oral D. Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int. J. Cardiol 2001;78(2):143–149. 10. Saglam M, Karakaya O, Barutcu I, Esen AM, Turkmen M, Kargin R, et al. Identifying cardiovascular risk factors in a patient population with coronary artery ectasia. Angiology 2007;58(6):698–703. 11. Mrdović I, Jozić T, Asanin M, Perunicić J, Ostojić M. Myocardial reinfarction in a patient with coronary ectasia. Cardiology 2004;102(1):32–34.
  • 12. Kühl M, Varma C. A case of acute coronary thrombosis in diffuse coronary artery ectasia. J. Invasive Cardiol 2008;20(1):E23–E25.
  • 13. Rath S, Har-Zahav Y, Battler A, Agranat O, Rotstein Z, Rabinowitz B, et al. Fate of nonobstructive aneurysmatic coronary artery disease: angiographic and clinical follow-up report. Am. Heart J 1985;109(4):785–791.
  • 14. Akyürek O, Berkalp B, Sayin T, Kumbasar D, Kervancioğlu C, Oral D. Altered coronary flow properties in diffuse coronary artery ectasia. Am. Heart J 2003;145(1):66–72. 15. Syed M, Lesch M. Coronary artery aneurysm: a review. Prog Cardiovasc Dis 1997;40:77-84.
  • 16. Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, et al. Aneurysmal coronary artery disease. Circulation 1983;67:134-142.
  • 17. Yip HK, Chen MC, Wu CJ, Hang CL, Hsieh KY, Fang CY, et al. Clinical features and outcome of coronary artery aneurysm in patients with acute myocardial infarction undergoing a primary percutaneous coronary intervention. Cardiology 2002;98:132-140.
  • 18. Hudzik B, Szkodzinski J, Lekston A, Gierlotka M, Polonski L, Gasior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications 2016;30:1097-1102.
  • 19. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-161.
  • 20. Pitchford SC, Page CP. Platelet activation in asthma: integral to the inflammatory response. Clin Exp Allergy 2006;36:399-401.
  • 21. Dastjerdi MS, Emami T, Najafian A, Amini M. Mean platelet volume measurement, EDTA or citrate? Hematology 2006;11(5):317-319.
  • 22. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75(3):291-294.
  • 23. Aktas G, Sit M, Tekce H, Alcelik A, Savli H, Simsek T, Ozmen E, et al. Mean platelet volume in nasal polyps. The West Indian Med J 2013; 62(6):515-518.
  • 24. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation?. Curr Pharm Des 2011;17(1):47-58.
  • 25. Ozbek K, Katlandur H, Keser H, Ulucan S, Ozdil H, Ulgen MS. Is there a relationship between mean platelet volume and the severity of coronary ectasia?. Biomedical Research 2016; 27 (3): 816-820.
  • 26. P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, C.H. Hennekens. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med 1997;336: 973–979.
  • 27. R. Ross. Atherosclerosis–an inflammatory disease. N. Engl. J. Med 1999;340: 115–126.

Koroner Arter Ektazisinde Ortalama Trombosit Hacmi Düşüktür!

Year 2020, , 225 - 230, 15.06.2020
https://doi.org/10.31832/smj.696747

Abstract

Özet



Amaç: Koroner arter ektazi (KAE), bir koroner
arterin bir segmentinin bitişiğindeki segmente göre  en az 1.5 katı genişlemesi olarak tanımlanır.
Birçok çalışma, ortalama trombosit hacmi (OTH) ile kardiyovasküler hastalıklar
arasındaki ilişkiyi göstermiştir. Ancak çalışmaların sonuçları farklı olup kafa
karıştırıcıdır. Bu nedenle OTH ile KAE ilişkisini araştırmayı amaçladık.



Gereç ve
yöntemler:
Koroner arterleri normal
90 hasta ve KAE' li 70 hasta çalışmaya dahil edildi. Anjiyografiden  önce rutin kan ve biyokimyasal parametreler
çalışıldı. Sürekli değişkenler için gruplar arasındaki farklar t-testi veya
Mann-Whitney U testi ile analiz edildi. P <0,05 değerleri anlamlı kabul
edildi.



Bulgular: Hastaların başlıca yaş ve klinik risk
faktörlerini içeren ​​demografik verileri gruplar arasında benzerdi. Kontrol
grubuyla karşılaştırıldığında, OTH düzeyleri KAE grubunda anlamlı olarak
düşüktü (8.84 ± 1.71fL ve 10.43 ± 1.34, p <0.001).  MPV seviyesi <9,5 fL iken KAE tahmini için  duyarlılık ve 
özgüllük değerleri sırasıyla % 95,% 80; eğri altında kalan alan = 0,943,
% 95 CI, 0.906–0.980) olarak bulundu.



Sonuç:  Bu
çalışma KAE' li hastalarda OTH' nin düşebileceğini düşündürmektedir.

References

  • References 1. Hartnell GG, Parnell BM, Pridie RB, Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients.Br Heart J 1985;54:392-397.
  • 2. Yamanaka O, Hobbs RE. Coronary artery anomalies in 126.595 patients undergoing coronary arteriography. Cather Cardiovasc Diagn 1990;21:28-40.
  • 3. Pinar Bermúdez E, López Palop R, Lozano Martínez-Luengas I, Cortés Sánchez R, Carrillo Sáez P, Rodríguez Carreras R, et al. Coronary ectasia: Prevalence, and cilinical and angiographic characteristics. Rev Esp Cardiol 2003;56:473-482.
  • 4. Daoud AS, Pankin D, Tulgan H, Florentin RA. Aneurysms of the coronary artery. Report of ten cases and review of literature. Am J Cardiol 1963;11:228-237.
  • 5. Sharma SN, Kaul U, Sharma S, Wasir HS, Manchanda SC, Bahl VK, et al. Coronary arteriographic profile in young and old Indian patients with ischemic heart disease: A comparative study. Indian Heart J 1990;42:365-374.
  • 6. Befeler B, Embi A, Mullin FL, Aranda MJ,El-Sherif N, Lazzara R. Coronary artery aneurysms: Study of the etiology, clinical course and effecton left ventricular function and prognosis. Am J Med 1977; 62:597-607.
  • 7. Sezer M, Okcular I, Goren T, Oflaz H, Nisanci Y, Umman B, et al. Association of haematological indices with the degree of microvascular injury in patients with acute anterior wall myocardial infarction treated with primary percutaneous coronary intervention. Heart 2007;93:313–318.
  • 8. Aboeata AS, Sontineni SP, Alla VM, Esterbrooks DJ. Coronary artery ectasia: current concepts and interventions. Front. Biosci. (Elite Ed.) 2012;4:300–310.
  • 9. Sayin T, Döven O, Berkalp B, Akyürek O, Güleç S, Oral D. Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int. J. Cardiol 2001;78(2):143–149. 10. Saglam M, Karakaya O, Barutcu I, Esen AM, Turkmen M, Kargin R, et al. Identifying cardiovascular risk factors in a patient population with coronary artery ectasia. Angiology 2007;58(6):698–703. 11. Mrdović I, Jozić T, Asanin M, Perunicić J, Ostojić M. Myocardial reinfarction in a patient with coronary ectasia. Cardiology 2004;102(1):32–34.
  • 12. Kühl M, Varma C. A case of acute coronary thrombosis in diffuse coronary artery ectasia. J. Invasive Cardiol 2008;20(1):E23–E25.
  • 13. Rath S, Har-Zahav Y, Battler A, Agranat O, Rotstein Z, Rabinowitz B, et al. Fate of nonobstructive aneurysmatic coronary artery disease: angiographic and clinical follow-up report. Am. Heart J 1985;109(4):785–791.
  • 14. Akyürek O, Berkalp B, Sayin T, Kumbasar D, Kervancioğlu C, Oral D. Altered coronary flow properties in diffuse coronary artery ectasia. Am. Heart J 2003;145(1):66–72. 15. Syed M, Lesch M. Coronary artery aneurysm: a review. Prog Cardiovasc Dis 1997;40:77-84.
  • 16. Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, et al. Aneurysmal coronary artery disease. Circulation 1983;67:134-142.
  • 17. Yip HK, Chen MC, Wu CJ, Hang CL, Hsieh KY, Fang CY, et al. Clinical features and outcome of coronary artery aneurysm in patients with acute myocardial infarction undergoing a primary percutaneous coronary intervention. Cardiology 2002;98:132-140.
  • 18. Hudzik B, Szkodzinski J, Lekston A, Gierlotka M, Polonski L, Gasior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications 2016;30:1097-1102.
  • 19. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-161.
  • 20. Pitchford SC, Page CP. Platelet activation in asthma: integral to the inflammatory response. Clin Exp Allergy 2006;36:399-401.
  • 21. Dastjerdi MS, Emami T, Najafian A, Amini M. Mean platelet volume measurement, EDTA or citrate? Hematology 2006;11(5):317-319.
  • 22. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75(3):291-294.
  • 23. Aktas G, Sit M, Tekce H, Alcelik A, Savli H, Simsek T, Ozmen E, et al. Mean platelet volume in nasal polyps. The West Indian Med J 2013; 62(6):515-518.
  • 24. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation?. Curr Pharm Des 2011;17(1):47-58.
  • 25. Ozbek K, Katlandur H, Keser H, Ulucan S, Ozdil H, Ulgen MS. Is there a relationship between mean platelet volume and the severity of coronary ectasia?. Biomedical Research 2016; 27 (3): 816-820.
  • 26. P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, C.H. Hennekens. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med 1997;336: 973–979.
  • 27. R. Ross. Atherosclerosis–an inflammatory disease. N. Engl. J. Med 1999;340: 115–126.
There are 24 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Çağrı Zorlu 0000-0003-4085-8151

Cemal Köseoğlu 0000-0001-8911-3340

Publication Date June 15, 2020
Submission Date March 3, 2020
Published in Issue Year 2020

Cite

AMA Zorlu Ç, Köseoğlu C. Mean Platelet Volume and Coronary Artery Ectasia. Sakarya Tıp Dergisi. June 2020;10(2):225-230. doi:10.31832/smj.696747

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