Mean Platelet Volume and Coronary Artery Ectasia

Year 2020, , 225 - 230, 15.06.2020

Çağrı Zorlu , Cemal Köseoğlu

https://doi.org/10.31832/smj.696747

Abstract

 

Abstract

Objective:
Coronary artery ectasia (CAE) are defined as
the dilation of a segment of a coronary artery at least 1.5 times the adjacent
segment. Several studies have shown the association between
mean platelet volume (MPV) and cardiovascular diseases. But
the results are different. For this
reason, we aimed to investigate the association of MPV with CAE.

Materials
and Methods: 90 patients with normal
coronary arteries and 70 patients with CAE were included. Routine blood and
biochemical parameters were measured before the arteriography. Differences
between groups for continuous variables were analyzed with t- test or
Mann-Whitney U test. P values < 0.05 were considered significant.

Results: Baseline patient demographics, including age and
clinical risk factors, were similar between the groups. Compared to the control
group, MPV levels were significantly lower in the CAE group (8.84 ± 1.71fL vs.
10.43 ± 1.34, p < 0.001). MPV level of < 9,5 fL showed sensitivity ,
specificity value of 95%, 80%; area under the curve= 0.943, 95% CI, 0.906–0.980) for the
prediction of CAE.

Conclusion: The present study suggests that MPV may decrease in
patients with CAE.

Keywords

Angiography, Coronary Aneurysms, Coronary Artery Disesas, Mean Platelet Volume.

Koroner Arter Ektazisinde Ortalama Trombosit Hacmi Düşüktür!

Abstract

Özet

Amaç: Koroner arter ektazi (KAE), bir koroner
arterin bir segmentinin bitişiğindeki segmente göre  en az 1.5 katı genişlemesi olarak tanımlanır.
Birçok çalışma, ortalama trombosit hacmi (OTH) ile kardiyovasküler hastalıklar
arasındaki ilişkiyi göstermiştir. Ancak çalışmaların sonuçları farklı olup kafa
karıştırıcıdır. Bu nedenle OTH ile KAE ilişkisini araştırmayı amaçladık.

Gereç ve
yöntemler: Koroner arterleri normal
90 hasta ve KAE' li 70 hasta çalışmaya dahil edildi. Anjiyografiden  önce rutin kan ve biyokimyasal parametreler
çalışıldı. Sürekli değişkenler için gruplar arasındaki farklar t-testi veya
Mann-Whitney U testi ile analiz edildi. P <0,05 değerleri anlamlı kabul
edildi.

Bulgular: Hastaların başlıca yaş ve klinik risk
faktörlerini içeren ​​demografik verileri gruplar arasında benzerdi. Kontrol
grubuyla karşılaştırıldığında, OTH düzeyleri KAE grubunda anlamlı olarak
düşüktü (8.84 ± 1.71fL ve 10.43 ± 1.34, p <0.001).  MPV seviyesi <9,5 fL iken KAE tahmini için  duyarlılık ve 
özgüllük değerleri sırasıyla % 95,% 80; eğri altında kalan alan = 0,943,
% 95 CI, 0.906–0.980) olarak bulundu.

Sonuç:  Bu
çalışma KAE' li hastalarda OTH' nin düşebileceğini düşündürmektedir.

Keywords

Anjiyografi, Koroner arter hastalığı, Ortalama trombosit hacmi, Koroner anevrizma, Koroner arter hastalığı

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