SARS-CoV-2 Enfeksiyonlu Hastalarda Eşlik Eden Oküler Hastalıklar

Abstract

Amaç: Nazofaringeal ve orofaringeal sürüntülerde SARS-CoV-2 virüsü için gerçek zamanlı ters transkripsiyon-polimeraz zincir reaksiyonu (rRT-PCR) testi pozitif olan hastalarda oküler hastalıkların varlığını araştırmak. Gereç ve Yöntemler: SARS-CoV-2 virüsü açısından rRT-PCR testi pozitif olan hastanede yatan hastaların dosyaları geriye dönük tarandı. Bu hastalardan son bir yıl içinde göz polikliniğine başvuran hastalar çalışmaya dahil edildi ve almış oldukları tanılar kayıt edildi. Bulgular: Bu çalışmada rRT-PCR testi pozitif olan 1120 hasta incelendi. Bu hastaların 178'i (% 15,8) daha önce göz kliniklerine başvurmuştu. En sık görülen hastalıklar kırma kusurları, kuru göz sendromu, blefarokonjonktivit ve alerjik konjonktivit idi. Sonuç: SARS-CoV-2 varlığı doğrulanmış hastalarda eşlik eden oküler hastalık oranı % 15.8 idi. Kronik göz hastalıklarının, el-yüz teması nedeni ile SARS-CoV-2 enfeksiyonunun bulaştırıcılığı arttırabileceğini düşünüyoruz.

Keywords

• SARS-CoV-2
• COVID-19
• göz hastalıkları

Concomitant Ocular Diseases in Patients with SARS-CoV-2 Infection

Abstract

Objective: To investigate the presence of chronic ocular diseases in patients who had a positive polymerase chain reaction (PCR) test of oropharyngeal/nasopharyngeal swabs for SARS-CoV-2 virus. Material and Methods: A retrospective chart review was conducted to determine all hospitalized patients who had a positive rRT‐PCR test for SARS-CoV-2 virus. From these patients, who applied to eye polyclinics in the last one year were included and the diagnosis was investigated. Results: This study investigated 1120 patients with a positive rRT‐PCR test. Of these patients, 178 (15.8%) had applied to eye clinics previously. The most common diseases were refractive errors, dry eye syndrome, blepharoconjunctivitis, and allergic conjunctivitis. Conclusion: The rate of concomitant ocular diseases in patients with confirmed SARS-CoV-2 was 15.8%. Avoiding touching the face and eyes and hand hygiene were the main prevention ways from SARS-CoV-2 infection. Concomitant ocular diseases might increase the risk of contact transmission routes.

Keywords

• SARS-CoV-2
• COVID-19
• eye disease

References

1. 1. Weiss SR, Navas-Martin S. Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus [Internet]. Vol. 69, Microbiology and Molecular Biology Reviews. 2005. p. 635–64. Available from: http://dx.doi.org/10.1128/mmbr.69.4.635-664.2005
2. 2. Moorthy V, Henao Restrepo AM, Preziosi M-P, Swaminathan S. Data sharing for novel coronavirus (COVID-19). Bull World Health Organ. 2020;98(3):150.
3. 3. Moorthy V, Henao Restrepo AM, Preziosi M-P, Swaminathan S. Data sharing for novel coronavirus (COVID-19). Bull World Health Organ. 2020;98(3):150.
4. 4. Weiss SR, Navas-Martin S. Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus [Internet]. Vol. 69, Microbiology and Molecular Biology Reviews. 2005. p. 635–64. Available from: http://dx.doi.org/10.1128/mmbr.69.4.635-664.2005
5. 5. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci. 2020;12(1):9.
6. 6. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565–74.
7. 7. Lu C-W, Liu X-F, Jia Z-F. 2019-nCoV transmission through the ocular surface must not be ignored [Internet]. Vol. 395, The Lancet. 2020. p. e39. Available from: http://dx.doi.org/10.1016/s0140-6736(20)30313-5
8. 8. Ma D, Chen C-B, Jhanji V, Xu C, Yuan X-L, Liang J-J, et al. Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea. Eye . 2020;34(7):1212–9.

9. 9. Leonardi A, Rosani U, Brun P. Ocular Surface Expression of SARS-CoV-2 Receptors. Ocul Immunol Inflamm. 2020;1–4.
10. 10. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020;8(4):e21.
11. 11. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci. 2020;12(1):9.
12. 12. Adhikari SP, Meng S, Wu Y-J, Mao Y-P, Ye R-X, Wang Q-Z, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty. 2020;9(1):29.
13. 13. McGinnigle S, Naroo SA, Eperjesi F. Evaluation of dry eye. Surv Ophthalmol. 2012;57(4):293–316.
14. 14. Bernardes TF, Bonfioli AA. Blepharitis. Semin Ophthalmol. 2010;25(3):79–83.
15. 15. Kuruvilla M, Kalangara J, Lee FE-H. Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis. J Investig Allergol Clin Immunol. 2019;29(5):349–56.
16. 16. Zeng W, Wang X, Li J, Yang Y, Qiu X, Song P, et al. Association of Daily Wear of Eyeglasses With Susceptibility to Coronavirus Disease 2019 Infection. JAMA Ophthalmol [Internet]. 2020 Sep 16; Available from: http://dx.doi.org/10.1001/jamaophthalmol.2020.3906
17. 17. Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, et al. Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study [Internet]. Available from: http://dx.doi.org/10.1101/2020.03.12.20034678
18. 18. Seah I, Agrawal R. Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals. Ocul Immunol Inflamm. 2020; 2;28(3):391–5.
19. 19. Bostanci Ceran B, Ozates S. Ocular manifestations of coronavirus disease 2019. Graefes Arch Clin Exp Ophthalmol [Internet]. 2020; Available from: http://dx.doi.org/10.1007/s00417-020-04777-7
20. 20. Valente P, Iarossi G, Federici M, Petroni S, Palma P, Cotugno N, et al. Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report. J AAPOS [Internet]. 2020; Available from: http://dx.doi.org/10.1016/j.jaapos.2020.05.002
21. 21. Sun X, Zhang X, Chen X, Chen L, Deng C, Zou X, et al. The infection evidence of SARS-COV-2 in ocular surface： a single-center cross-sectional study [Internet]. Available from: http://dx.doi.org/10.1101/2020.02.26.20027938
22. 22. Chen L, Liu M, Zhang Z, Qiao K, Huang T, Chen M, et al. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020;104(6):748–51.
23. 23. Bozkurt E, Özateş S, Muhafız E, Yılmaz F, Calıskan O. Ocular Surface and Conjunctival Cytology Findings in Patients with Confirmed COVID-19. Eye Contact Lens. 2020 Oct 13. doi: 10.1097/ICL.0000000000000752. Epub ahead of print.