Research Article
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Year 2021, , 305 - 311, 29.06.2021
https://doi.org/10.31832/smj.824455

Abstract

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Project Number

None

Thanks

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References

  • 1. Şahi̇nkuş S, Aksoy MNM, Aydin E, Eynel E, Akçay Ç, Kocayi̇ği̇t İ, et al. 2018 Yılında Tek Merkezde Primer Perkutan Koroner Girişim Yapılan Hastaların Klinik Özellikleri, Anjiyografi İşleminin ve Hastane İçi Klinik Sonuçların Analizi. Sakarya Tıp Dergisi. 2020 Jun 15;10(2):197–204.
  • 2. Can Y, Şahi̇nkuş S. Perkütan Koroner Girişime Bağlı İyatrojenik Koroner Arter Perfosyonu Gelişen Hastaların Demografik Özelliklerinin ve Tedavilerinin Değerlendirilmesi: Tek Merkez Deneyimi. Sakarya Tıp Dergisi. 2020 Sep 15;10(3):490–7.
  • 3. Ellis SG, Ajluni S, Arnold AZ, Popma JJ, Bittl JA, Eigler NL, et al. Increased coronary perforation in the new device era. Incidence, classification, management, and outcome. Circulation. 1994 Dec;90(6):2725–30.
  • 4. Shimony A, Joseph L, Mottillo S, Eisenberg MJ. Coronary artery perforation during percutaneous coronary intervention: a systematic review and meta-analysis. Can J Cardiol. 2011 Dec;27(6):843–50.
  • 5. Stankovic G, Orlic D, Corvaja N, Airoldi F, Chieffo A, Spanos V, et al. Incidence, predictors, in-hospital, and late outcomes of coronary artery perforations. Am J Cardiol. 2004 Jan 15;93(2):213–6.
  • 6. Fasseas P, Orford JL, Panetta CJ, Bell MR, Denktas AE, Lennon RJ, et al. Incidence, correlates, management, and clinical outcome of coronary perforation: analysis of 16,298 procedures. American Heart Journal. 2004 Jan 1;147(1):140–5.
  • 7. Libby P, Ridker PM, Hansson GK. Inflammation in Atherosclerosis: From Pathophysiology to Practice. J Am Coll Cardiol. 2009 Dec 1;54(23):2129–38.
  • 8. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther. 2013 Jan;11(1):55–9.
  • 9. Turna F, Enhoş A. Can the neutrophil to lymphocyte ratio, determined in the whole blood count, be used as a mortality marker in patients with pulmonary thromboembolism ? Sakarya Tıp Dergisi. 2020 Sep 15;10(3):422–9.
  • 10. Fukuta H, Ohte N, Mukai S, Saeki T, Asada K, Wakami K, et al. Elevated plasma levels of B-type natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J. 2009 May;50(3):301–12.
  • 11. Thygesen Kristian, Alpert Joseph S., Jaffe Allan S., Chaitman Bernard R., Bax Jeroen J., Morrow David A., et al. Fourth Universal Definition of Myocardial Infarction (2018). Circulation. 2018 Nov 13;138(20):e618–51.
  • 12. Gunning MG, Williams IL, Jewitt DE, Shah AM, Wainwright RJ, Thomas MR. Coronary artery perforation during percutaneous intervention: incidence and outcome. Heart. 2002 Nov;88(5):495–8.
  • 13. Shimony A, Zahger D, Van Straten M, Shalev A, Gilutz H, Ilia R, et al. Incidence, risk factors, management and outcomes of coronary artery perforation during percutaneous coronary intervention. Am J Cardiol. 2009 Dec 15;104(12):1674–7.
  • 14. Lee MS, Shamouelian A, Dahodwala MQ. Coronary Artery Perforation Following Percutaneous Coronary Intervention. J Invasive Cardiol. 2016 Mar;28(3):122–31.
  • 15. Briet M, Bozec E, Laurent S, Fassot C, London GM, Jacquot C, et al. Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease. Kidney Int. 2006 Jan;69(2):350–7.
  • 16. ECOBICI M, STOICESCU C. Arterial Stiffness and Hypertension – Which Comes First? Maedica (Bucur). 2017 Sep;12(3):184–90.
  • 17. Miguel CD, Rudemiller NP, Abais JM, Mattson DL. Inflammation and hypertension: new understandings and potential therapeutic targets. Curr Hypertens Rep. 2015 Jan;17(1):507.
  • 18. Akchurin OM, Kaskel F. Update on Inflammation in Chronic Kidney Disease. BPU. 2015;39(1–3):84–92.
  • 19. Park S, Lakatta EG. Role of Inflammation in the Pathogenesis of Arterial Stiffness. Yonsei Med J. 2012 Mar 1;53(2):258–61.
  • 20. Fioranelli M, Bottaccioli AG, Bottaccioli F, Bianchi M, Rovesti M, Roccia MG. Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based. Front Immunol. 2018;9:2031.
  • 21. Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H. Atherosclerosis: Process, Indicators, Risk Factors and New Hopes. Int J Prev Med. 2014 Aug;5(8):927–46.
  • 22. Gillum RF, Mussolino ME, Madans JH. Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol. 2005 Apr;15(4):266–71.
  • 23. Gurm HS, Bhatt DL, Lincoff AM, Tcheng JE, Kereiakes DJ, Kleiman NS, et al. Impact of preprocedural white blood cell count on long term mortality after percutaneous coronary intervention: insights from the EPIC, EPILOG, and EPISTENT trials. Heart. 2003 Oct;89(10):1200–4.
  • 24. Kandemi̇r A, Süle M, Yavaşoğlu İ, Türe M, Coşkun A, Yükselen A, et al. Assessment of the Relationship Between Leukocyte Count and Neutrophil-to-Lymphocyte Ratio and Clinical Course in Non-Variceal Upper Gastrointestinal System Bleeding. Sakarya Tıp Dergisi. 2018 Jun 29;8(2):320–6.
  • 25. Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an Elevated Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality After Percutaneous Coronary Intervention. American Journal of Cardiology. 2006 Apr 1;97(7):993–6.
  • 26. Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil–lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clinica Chimica Acta. 2008 Sep 1;395(1):27–31.
  • 27. Sönmez O, Ertaş G, Bacaksız A, Tasal A, Erdoğan E, Asoğlu E, et al. Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study. Anadolu Kardiyol Derg. 2013 Nov;13(7):662–7.
  • 28. Yıldız A, Yildiz C, Tekiner F, Bağırtan B. Preprocedural Neutrophil To Lymphocyte Ratio Predıcts Coronary Artery Perforation. In 2014.
  • 29. Uyarel H, Isik T, Ayhan E, Ergelen M. Red cell distrubition width (RDW): a novel risk factor for cardiovascular disease. Int J Cardiol. 2012 Feb 9;154(3):351–2.
  • 30. Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion. 2005 Mar;20(2):83–90.

Koroner Arter Perforasyonu Gelişiminde Nötrofil-Lenfosit Oranının Rolü

Year 2021, , 305 - 311, 29.06.2021
https://doi.org/10.31832/smj.824455

Abstract

Amaç: Koroner arter perforasyonu (KAP), peruktan koroner girişim (PKG) sırasında seyrek olarak rastlanan ancak ölümcül sonuçları olabilen bir komplikasyondur. Nötrofil lenfosit oranı (NLO), birçok kardiyovasküler hastalığın şiddeti ve prognozu ile ilişkili olduğu bilinen yeni bir enflamatuar belirteçtir. KAP gelişimi ile NLO ve kırmızı hücre dağılım genişliği (RDW) ilişkisini araştırmayı hedefledik.
Gereç ve Yöntemler: 2012-2018 yıllarında, iki farklı merkezde PKG yapılan toplam 15199 hasta geriye yönelik olarak tarandı. Bu enine kesit gözlemsel retrospektif çalışmaya PKG sırasında koroner perofrasyon gelişen 50 hasta ve koroner perforasyon gelişmemiş 100 hasta dahil edildi. Tam kan sayımı parametreleri bu iki grup arasında karşılaştırıldı. NLO, nötrofil sayısının lenfosit sayısına oranı olarak hesaplandı.
Bulgular: PKG yapılan 15199 hastanın 50'sinde (% 0.32)( ortalama yaş 63,2 ± 12,2, % 64 erkek) koroner perforasyon meydana geldi. Perforasyonların çoğu sol ön inen arterde (LAD) (n = 27,% 54), ardından sağ koroner arterde (RCA) (n = 13,% 26) izlendi. En sık Ellis tip II KAP(%52) görülürken, başlıca perforasyon nedeni balon anjiyoplastiydi (%42). NLO (medyan 3,3 ( 4,0)'e karşı medyan 2,3 (1,6), p<0.001) ve RDW (medyan 14,2 ( 2,0)'e karşı medyan 13,5 (1,3), p=0.002) KAP grubunda anlamlı olarak daha yüksekti.
Sonuç: Perkutan koroner girişim yapılan hastalarda yüksek NLO ve RDW seviyeleri koroner arterde perforasyon ile ilişkilidir.

Project Number

None

References

  • 1. Şahi̇nkuş S, Aksoy MNM, Aydin E, Eynel E, Akçay Ç, Kocayi̇ği̇t İ, et al. 2018 Yılında Tek Merkezde Primer Perkutan Koroner Girişim Yapılan Hastaların Klinik Özellikleri, Anjiyografi İşleminin ve Hastane İçi Klinik Sonuçların Analizi. Sakarya Tıp Dergisi. 2020 Jun 15;10(2):197–204.
  • 2. Can Y, Şahi̇nkuş S. Perkütan Koroner Girişime Bağlı İyatrojenik Koroner Arter Perfosyonu Gelişen Hastaların Demografik Özelliklerinin ve Tedavilerinin Değerlendirilmesi: Tek Merkez Deneyimi. Sakarya Tıp Dergisi. 2020 Sep 15;10(3):490–7.
  • 3. Ellis SG, Ajluni S, Arnold AZ, Popma JJ, Bittl JA, Eigler NL, et al. Increased coronary perforation in the new device era. Incidence, classification, management, and outcome. Circulation. 1994 Dec;90(6):2725–30.
  • 4. Shimony A, Joseph L, Mottillo S, Eisenberg MJ. Coronary artery perforation during percutaneous coronary intervention: a systematic review and meta-analysis. Can J Cardiol. 2011 Dec;27(6):843–50.
  • 5. Stankovic G, Orlic D, Corvaja N, Airoldi F, Chieffo A, Spanos V, et al. Incidence, predictors, in-hospital, and late outcomes of coronary artery perforations. Am J Cardiol. 2004 Jan 15;93(2):213–6.
  • 6. Fasseas P, Orford JL, Panetta CJ, Bell MR, Denktas AE, Lennon RJ, et al. Incidence, correlates, management, and clinical outcome of coronary perforation: analysis of 16,298 procedures. American Heart Journal. 2004 Jan 1;147(1):140–5.
  • 7. Libby P, Ridker PM, Hansson GK. Inflammation in Atherosclerosis: From Pathophysiology to Practice. J Am Coll Cardiol. 2009 Dec 1;54(23):2129–38.
  • 8. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther. 2013 Jan;11(1):55–9.
  • 9. Turna F, Enhoş A. Can the neutrophil to lymphocyte ratio, determined in the whole blood count, be used as a mortality marker in patients with pulmonary thromboembolism ? Sakarya Tıp Dergisi. 2020 Sep 15;10(3):422–9.
  • 10. Fukuta H, Ohte N, Mukai S, Saeki T, Asada K, Wakami K, et al. Elevated plasma levels of B-type natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J. 2009 May;50(3):301–12.
  • 11. Thygesen Kristian, Alpert Joseph S., Jaffe Allan S., Chaitman Bernard R., Bax Jeroen J., Morrow David A., et al. Fourth Universal Definition of Myocardial Infarction (2018). Circulation. 2018 Nov 13;138(20):e618–51.
  • 12. Gunning MG, Williams IL, Jewitt DE, Shah AM, Wainwright RJ, Thomas MR. Coronary artery perforation during percutaneous intervention: incidence and outcome. Heart. 2002 Nov;88(5):495–8.
  • 13. Shimony A, Zahger D, Van Straten M, Shalev A, Gilutz H, Ilia R, et al. Incidence, risk factors, management and outcomes of coronary artery perforation during percutaneous coronary intervention. Am J Cardiol. 2009 Dec 15;104(12):1674–7.
  • 14. Lee MS, Shamouelian A, Dahodwala MQ. Coronary Artery Perforation Following Percutaneous Coronary Intervention. J Invasive Cardiol. 2016 Mar;28(3):122–31.
  • 15. Briet M, Bozec E, Laurent S, Fassot C, London GM, Jacquot C, et al. Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease. Kidney Int. 2006 Jan;69(2):350–7.
  • 16. ECOBICI M, STOICESCU C. Arterial Stiffness and Hypertension – Which Comes First? Maedica (Bucur). 2017 Sep;12(3):184–90.
  • 17. Miguel CD, Rudemiller NP, Abais JM, Mattson DL. Inflammation and hypertension: new understandings and potential therapeutic targets. Curr Hypertens Rep. 2015 Jan;17(1):507.
  • 18. Akchurin OM, Kaskel F. Update on Inflammation in Chronic Kidney Disease. BPU. 2015;39(1–3):84–92.
  • 19. Park S, Lakatta EG. Role of Inflammation in the Pathogenesis of Arterial Stiffness. Yonsei Med J. 2012 Mar 1;53(2):258–61.
  • 20. Fioranelli M, Bottaccioli AG, Bottaccioli F, Bianchi M, Rovesti M, Roccia MG. Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based. Front Immunol. 2018;9:2031.
  • 21. Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H. Atherosclerosis: Process, Indicators, Risk Factors and New Hopes. Int J Prev Med. 2014 Aug;5(8):927–46.
  • 22. Gillum RF, Mussolino ME, Madans JH. Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol. 2005 Apr;15(4):266–71.
  • 23. Gurm HS, Bhatt DL, Lincoff AM, Tcheng JE, Kereiakes DJ, Kleiman NS, et al. Impact of preprocedural white blood cell count on long term mortality after percutaneous coronary intervention: insights from the EPIC, EPILOG, and EPISTENT trials. Heart. 2003 Oct;89(10):1200–4.
  • 24. Kandemi̇r A, Süle M, Yavaşoğlu İ, Türe M, Coşkun A, Yükselen A, et al. Assessment of the Relationship Between Leukocyte Count and Neutrophil-to-Lymphocyte Ratio and Clinical Course in Non-Variceal Upper Gastrointestinal System Bleeding. Sakarya Tıp Dergisi. 2018 Jun 29;8(2):320–6.
  • 25. Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an Elevated Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality After Percutaneous Coronary Intervention. American Journal of Cardiology. 2006 Apr 1;97(7):993–6.
  • 26. Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil–lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clinica Chimica Acta. 2008 Sep 1;395(1):27–31.
  • 27. Sönmez O, Ertaş G, Bacaksız A, Tasal A, Erdoğan E, Asoğlu E, et al. Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study. Anadolu Kardiyol Derg. 2013 Nov;13(7):662–7.
  • 28. Yıldız A, Yildiz C, Tekiner F, Bağırtan B. Preprocedural Neutrophil To Lymphocyte Ratio Predıcts Coronary Artery Perforation. In 2014.
  • 29. Uyarel H, Isik T, Ayhan E, Ergelen M. Red cell distrubition width (RDW): a novel risk factor for cardiovascular disease. Int J Cardiol. 2012 Feb 9;154(3):351–2.
  • 30. Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion. 2005 Mar;20(2):83–90.
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Ersin Çağrı Şimşek 0000-0001-6179-8579

Serkan Ünlü 0000-0001-6179-8579

Project Number None
Publication Date June 29, 2021
Submission Date November 11, 2020
Published in Issue Year 2021

Cite

AMA Şimşek EÇ, Ünlü S. Koroner Arter Perforasyonu Gelişiminde Nötrofil-Lenfosit Oranının Rolü. Sakarya Tıp Dergisi. June 2021;11(2):305-311. doi:10.31832/smj.824455

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