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Purpura Fulminansın Nedeni Lamotrijin mi?: Olgu Sunumu

Year 2021, , 442 - 446, 29.06.2021
https://doi.org/10.31832/smj.835905

Abstract

Purpura fulminans çoğunlukla enfeksiyonlara sekonder ortaya çıkan ve mortalitenin yüksek olduğu bir sendromdur. Yaygın damar içi pıhtılaşmayla doku ve organ nekrozuna neden olabilmektedir. Ölümler genellikle multisistemik tromboz yada septik şok kaynaklıdır. Etiyolojik nedenin hızlıca bulunarak tedaviye başlanması hayati öneme sahiptir. Purpura fulminans nadiren ilaç kullanımı sonrasında da ortaya çıkabilmektedir. Lamotrijin de ciddi deri reaksiyonlarına neden olduğu için ilaca başladıktan sonra oluşan döküntüler dikkatle takip edilmelidir. Burada lamotrijin başlandıktan 20 gün sonra döküntüleri gelişen fakat lamotrijinin değil enfeksiyonun neden olduğu purpura fulminans vakasını sunuyoruz. Bu olgu lamotrijinin ciddi cilt reaksiyonlarına sebep olsada görülen her döküntüde suçlanmaması gerektiğine dikkat çekmek için sunulmuştur.

References

  • Alvestad S, Lydersen S, Brodtkorb E. Rash from antiepileptic drugs: influence by gender, age, and learning disability. Epilepsia 2007; 48:1360-5.
  • Wang X-q, Lang S-y, Shi X-b, Tian H-j, Wang R-f, Yang F. Antiepileptic drug-induced skin reactions: a retrospective study and analysis in 3793 Chinese patients with epilepsy. Clinical neurology and neurosurgery 2012; 114:862-5.
  • Ben-Menachem E. New antiepileptic drugs and non-pharmacological treatments. Current Opinion in Neurology 2000; 13:165-70.
  • Warner PM, Kagan R, Yakuboff K, Kemalyan N, Palmieri TL, Greenhalgh DG, et al. Current management of purpura fulminans: a multicenter study. The Journal of burn care & rehabilitation 2003; 24:119-26.
  • Ward KM, Celebi JT, Gmyrek R, Grossman ME. Acute infectious purpura fulminans associated with asplenism or hyposplenism. Journal of the American Academy of Dermatology 2002; 47:493-6.
  • Kosaraju N, Korrapati V, Thomas A, James B. Adult purpura fulminans associated with non-steroidal anti-inflammatory drug use. Journal of postgraduate medicine 2011; 57:145.
  • Okamura I, Nakamura Y, Katsurada Y, Sato K, Ikeda T, Kimura F. Successful corticosteroid treatment for purpura fulminans associated with quinolone. Internal Medicine 2016; 55:3047-51.
  • Letko E, Papaliodis DN, Papaliodis GN, Daoud YJ, Ahmed AR, Foster CS. Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature. Annals of Allergy, Asthma & Immunology 2005; 94:419-36.
  • de Prost N, Mekontso-Dessap A, Valeyrie-Allanore L, Van Nhieu JT, Duong T-A, Chosidow O, et al. Acute respiratory failure in patients with toxic epidermal necrolysis: clinical features and factors associated with mechanical ventilation. Critical care medicine 2014; 42:118-28.
Year 2021, , 442 - 446, 29.06.2021
https://doi.org/10.31832/smj.835905

Abstract

References

  • Alvestad S, Lydersen S, Brodtkorb E. Rash from antiepileptic drugs: influence by gender, age, and learning disability. Epilepsia 2007; 48:1360-5.
  • Wang X-q, Lang S-y, Shi X-b, Tian H-j, Wang R-f, Yang F. Antiepileptic drug-induced skin reactions: a retrospective study and analysis in 3793 Chinese patients with epilepsy. Clinical neurology and neurosurgery 2012; 114:862-5.
  • Ben-Menachem E. New antiepileptic drugs and non-pharmacological treatments. Current Opinion in Neurology 2000; 13:165-70.
  • Warner PM, Kagan R, Yakuboff K, Kemalyan N, Palmieri TL, Greenhalgh DG, et al. Current management of purpura fulminans: a multicenter study. The Journal of burn care & rehabilitation 2003; 24:119-26.
  • Ward KM, Celebi JT, Gmyrek R, Grossman ME. Acute infectious purpura fulminans associated with asplenism or hyposplenism. Journal of the American Academy of Dermatology 2002; 47:493-6.
  • Kosaraju N, Korrapati V, Thomas A, James B. Adult purpura fulminans associated with non-steroidal anti-inflammatory drug use. Journal of postgraduate medicine 2011; 57:145.
  • Okamura I, Nakamura Y, Katsurada Y, Sato K, Ikeda T, Kimura F. Successful corticosteroid treatment for purpura fulminans associated with quinolone. Internal Medicine 2016; 55:3047-51.
  • Letko E, Papaliodis DN, Papaliodis GN, Daoud YJ, Ahmed AR, Foster CS. Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature. Annals of Allergy, Asthma & Immunology 2005; 94:419-36.
  • de Prost N, Mekontso-Dessap A, Valeyrie-Allanore L, Van Nhieu JT, Duong T-A, Chosidow O, et al. Acute respiratory failure in patients with toxic epidermal necrolysis: clinical features and factors associated with mechanical ventilation. Critical care medicine 2014; 42:118-28.
There are 9 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Fatma Şimşek 0000-0003-1662-5534

Revza Tosunoğlu This is me 0000-0002-2675-0825

Büşra Solak This is me 0000-0002-6809-9399

Publication Date June 29, 2021
Submission Date December 5, 2020
Published in Issue Year 2021

Cite

AMA Şimşek F, Tosunoğlu R, Solak B. Purpura Fulminansın Nedeni Lamotrijin mi?: Olgu Sunumu. Sakarya Tıp Dergisi. June 2021;11(2):442-446. doi:10.31832/smj.835905

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