Subklavyen Arter Darlığı olan Hastalarda Ortalama Trombosit Hacmi

Year 2021, , 259 - 264, 29.06.2021

Yusuf Can , Salih Şahinkuş , İbrahim Kocayiğit , Muhammed N Murat Aksoy , Selcuk Yaylacı , Altuğ Ösken , Huseyin Gündüz , Ercan Aydın , Harun Kılıç , Ramazan Akdemir

https://doi.org/10.31832/smj.858568

Abstract

Amaç: Trombositler ve ortalama trombosit hacmi ateroskleroz ile ilişkilidir. Bu çalışmanın amacı, ortalama trombosit hacmi ile subklavyen arter darlığı arasındaki ilişkiyi araştırmaktı.
Materyal ve Metod: Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi kateter laboratuvarında Eylül 2010 - Eylül 2015 tarihleri arasında yapılan anjiyografi ile subklavyen arteriyel darlık tanısı alan hastalar retroolarak çalışmaya dahil edildi. Subklavyen arteriyel darlık hastaları ile anjiyografik açıdan benzer klinik ve demografik özelliklere sahip bir kontrol grubu oluşturuldu. Subklavyen arteriyel darlık hastaları (35 hasta) ve kontrol grubundaki hastalar (38 hasta) için ortalama trombosit hacmi ve diğer hemogram değerleri kayıt sisteminden geriye dönük olarak belirlenmiş ve karşılaştırılmıştır.
Bulgular: İki grup yaş, cinsiyet, ateroskleroz risk faktörleri, koroner arter hastalığı öyküsü ve ilaç kullanımı açısından birbirine benzerdi. Gruplar arasında hemogram parametreleri karşılaştırıldığında, ortalama trombosit hacmi subklavyen arteriyel darlığı olan hastalarda control grubuna göre anlamlı olarak yüksek saptandı (8.07 ± 1.41 vs 7.19 ± 0.52; p = 0.001).
Sonuç: Sonuç olarak, bu çalışma subklavyen arter darlığı olan hastalarda daha yüksek ortalama trombosit hacmi bulan ilk çalışma olmuştur. Hem trombositlerin ateroskleroz üzerindeki etkisi hem de diğer risk faktörleri ile yakın ilişkisi düşünüldüğünde MPV düzeyi subklavyen arter darlığının patogenezinde önemli bir faktör olabilir.

Keywords

Ateroskleroz, subklavyen arter darlığı, ortalama trombosit hacmi

Mean Platelet Volume in Patients with Subclavian Arterial Stenosis

Abstract

Objective: Thrombocytes and mean platelet volume (MPV) are related to atherosclerosis. The purpose of the present study was to investigate the relationship between MPV and subclavian arterial stenosis (SAS).
Materials and Methods: Patients who were diagnosed with SAS by an angiography performed in the catheter laboratory between September 2010 and September 2015 were included in this study. A control group with similar clinical and demographic characteristics as the patients with SAS in angiographic terms was formed. The MPV and other hemogram values for SAS patients (35 patients) and the patients in the control group (38 patients) were determined retrospectively from the registry system and then compared.
Results: The two groups were similar to each other in terms of demographic and clinical characteristics. When the hemogram parameters were compared between the groups, the MPV was detected as being significantly higher in patients with SAS (8.07 ± 1.41 vs 7.19 ± 0.52; p = 0.001).
Conclusion: In conclusion, this study was the first to find a higher MPV in patients with SAS. Considering both the effect of platelets on atherosclerosis and their close association with other risk factors, MPV level may be an important factor in pathogenesis of SAS.

Keywords

Atherosclerosis, subclavian arterial stenosis, mean platelet volume

References

• 1. Rodriguez-Lopez JA, Werner A, Martinez R, Torruella LJ, Ray LI, Diethrich EB. Stenting for atherosclerotic occlusive disease of the subclavian artery. Ann Vasc Surg. 1999; 13:254–260.
• 2. Byrne C, Tawfick W, Hynes N, Sultan S. Ten-year experience in subclavian revascularisation. A parallel comparative observational study. Vascular 2016; 24:378-82.
• 3. Reyna J, Peguero JG, Elmahdy HM, Santana O, Conde C. Subclavian artery stenosis: a case series and rewiew of literature. Rev Carciovascular Med. 2014; 15:189-95.
• 4. Saha T, Naqvi SY, Ayah OA, McCormick D, Goldberg S. Subclavian Artery Disease: Diagnosis and Therapy. Am J Med . 2017; 130:409-416.
• 5. Wrotniak L, Kabtak-Ziembicka A, Rostawieka A, Musialek P, Bogacki P, Trystula M, Zmudka K, Przew1ocki T. Resolution of ischemic symptoms after percutaneous angioplasty for symptomatic subclavian artery stenosis. J Vasc Surg. 2016; 64:684–691.
• 6. Koenen RR, Binder CJ. Platelets and coagulation factors: Established and novel roles in atherosclerosis and atherothrombosis. Atherosclerosis 2020; 307:78-79.
• 7. Polat H, Sarica MA, Bulut HT, Yucel MO, Gok A, Cift A, et al. The relationship between mean platelet volume and other platelet indices with testicular artery blood flow and fertility: a preliminary study. Int. J. Clin. Exp. Med. 2015; 8:11554-11558.
• 8. Mohamed AB, Elnady HM, Alhewaig HK, Moslem Hefny H, Khodery A. The mean platelet volume and plateletcrit as predictors of short-term outcome of acute ischemic stroke. Egypt J Neurol Psychiatr Neurosurg. 2019; 55:4.
• 9. Yılmaz F, Köklü E, Kizilirmak Yilmaz F, Sarıönder Gencer E, Alparslan AŞ, Yıldırımtürk Ö. Evaluation of mean platelet volume and platelet distribution width in patients with asymptomatic intermediate carotid artery plaque. Kardiol Pol. 2017; 75:35-41.
• 10. Pafili K, Penlioglou T, Mikhailidis DP, Papanas N. Mean platelet volume and coronary artery disease. Curr Opin Cardiol. 2019; 34:390–8.
• 11. Fateh Moghadam S, Bocksch W, Ruf A, Dickfeld T, Schartl M, Pogátsa-Murray G, et al. Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy. Circulation 2000; 102:890-7.
• 12. Mufty H, Janssen A, Schepers S. Dealing with symptomatic stenosis of the subclavian artery: Open or endovascular approach? A case report. Int. Journal of Surgery Case Reports 2012; 5:441-443.
• 13. Labropoulos N, Nandivada P, Bekelis K. Prevalence and impact of the subclavian steal syndrome. Ann Surg. 2010; 252:166–70.
• 14. Stone PA, Srivastiva M, Campbell JE, Mousa AY. Diagnosis and Treatment of Subclavian Artery Occlusive Disease. Expert Rev Cardiovasc Ther. 2010; 8:1275-1282.
• 15. Dzielinska Z, Januszewicz A, Demkow M, Makowiecka-Cieśla M, Prejbisz A, Naruszewicz M, et al. Cardiovascular risk factors in hypertensive patients with coronary artery disease and coexisting renal artery stenosis. J Hypertens. 2007; 25:663–70.
• 16. Sayin MR, Yavuz N, Karabag T, Cetiner MA, Oz II, Gungorduk OA, et al. Renal artery stenosis and mean platelet volume. Anatol J Cardiol, 2015; 16:197-201.
• 17. Conlon PJ, Little MA, Pieper K, Mark DB. Severity of renal vascular disease predicts mortality in patients undergoing coronary angiography. Kidney Int. 2001; 60:1490-7.
• 18. Türk U, Tengiz I, Özpelit E, Çelebiler A, Pekel N, Özyurtlu F, et al. The relationship between platelet indices and clinical features of coronary artery disease. Kardiol Pol. 2013; 71:1129–34.
• 19. Liuzzo G , Biasucci LM , Gallimore JR , Grillo RL , Rebuzzi AG , Pepys MB , et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994; 331:417–424.
• 20. Isik T, Ayhan E, Uyarel H, Ergelen M, Tanboga IH, Kurt M, et al. Increased mean platelet volume associated with extent of slow coronary flow. Cardiol J. 2012; 19:355-362.