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Evaluation of Choroidal Thickness in Pregnant Women with Intrauterine Growth Retardation by Optical Coherence Tomography

Year 2021, , 395 - 399, 29.06.2021
https://doi.org/10.31832/smj.861550

Abstract

Objective: We aimed to compare the choroidal thickness in pregnant women with intrauterine growth retardation, healthy pregnant women and healthy non-pregnant women using optical coherence tomography.
Materials and methods: Pregnant women who admitted to the pregnancy outpatient clinic and non-pregnant healthy women were included in the study at the university hospital between December 2016 and January 2018. Thirty-one healthy pregnant women, 30 pregnant women with intrauterine growth retardation, and 30 healthy women between the ages of 18-45 participated in the study. The choroidal thickness of the patients was measured by Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) method.
Results: The mean gestational week was 33.6 ± 3.2 weeks in healthy pregnant women, 34.2 ± 2.8 weeks in pregnant women with intrauterine growth retardation. There was no significant difference between weeks of gestation (p = 0.420). Choroidal thickness were 357.27 ± 59.25 μm, 352.27 ± 67.01 μm, and 337.87 ± 88.44 μm in healthy pregnant women, pregnant women with intrauterine growth retardation, and in healthy women, respectively. There was no significant difference between the groups in terms of choroidal thickness (p = 0.559). In addition, there was no difference between healthy pregnant women and pregnant women with intrauterine growth retardation in terms of choroidal thickness (p = 0.367).
Conclusion: No significant difference was found in terms of choroidal thickness between pregnant women with intrauterine growth retardation, healthy pregnant women and healthy women.

References

  • 1. Errera MH, Kohly RP, da Cruz L. Pregnancy-associated retinal diseases and their management. Surv Ophthalmol 2013;58(2):127–42.
  • 2. Rhee P, Dev S, Mieler WF. The development of choroidal neovascularization in pregnancy. Retina 1999;19(6):520–4.
  • 3. Polizzi S, Mahajan VB. Intravitreal anti-VEGF injections in pregnancy: case series and review of literature. J Ocul Pharmacol Ther 2015;31(10):605–10.
  • 4. Pole C, Gaw Stephanie SL, Tsui Irena I. Utility of optical coherence tomography angiography in pregnancy-associated central serous chorioretinopathy. Am J Ophthalmol Case Rep 2020;20:100979.
  • 5. Yeoh J, Rahman W, Chen F, Hooper C, Patel P, Tufail A, et al. Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2010;248(12):1719-28.
  • 6. Spaide RF, Koizumi H, Pozonni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008;146(4):496-500.
  • 7. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 2009;147(5):811-5.
  • 8. Regatieri CV, Branchini L, Fujimoto JG, Duker JS. Choroidal imaging using spectral-domain optical coherence tomography. Retina 2012;32(5):865-76.
  • 9. Ferreira BFA, Kreuz AC, Diniz PM, Rocha JVSS, Pimentel SLG. Spontaneous outer retinal layer recovery in a case of hypertensive choroidopathy secondary to pre-eclampsia: a multimodal evaluation. Arq Bras Oftalmol 2019;82(6):522-7.
  • 10. Jiang MS, Xu XL, Yang T, Li F, Zhang XD. Comparison of Choroidal Thickness in Preeclamptic, Healthy Pregnant, and Nonpregnant Women: A Systematic Review and Meta-Analysis. Ophthalmic Res 2019;62(1):1-10.
  • 11. Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci 2010;51:2173–6.
  • 12. Agawa T, Miura M, Ikuno Y, Makita S, Fabritius T, Iwasaki T, et al. Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2011;249:1485–92.
  • 13. Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 2009;148:445–50.
  • 14. Nishida Y, Fujiwara T, Imamura Y, Lima LH, Kurosaka D, Spaide RF. Choroidal thickness and visual acuity in highly myopic eyes. Retina 2012;32:1229-36.
  • 15. Maruko I, Iida T, Sugano Y, Ojima A, Sekiryu T. Subfoveal choroidal thickness in fellow eyes of patients with central serous chorioretinopathy. Retina 2011;31(8):1603-8.
  • 16. Harada T, Machida S, Fujiwara T, Nishida Y, Kurosaka D. Choroidal findings in idiopathic uveal effusion syndrome. Clin Ophthalmol 2011;5:1599-601.
  • 17. Baltmr A, Lightman S, Tomkins-Netzer O. Vogt-Koyanagi-Harada syndrome - current perspectives. Clin Ophthalmol 2016;10:2345-61.
  • 18. Temel E, Kocamış Ö, Aşıkgarip N, Örnek K, Arıöz O. Evaluation of choroidal thickness and choroidal vascularity index during pregnancy. Can J Ophthalmol 2021:S0008-4182(20)30836-X.
  • 19. Whittaker PG, Macphail S, Lind T. Serial hematologic changes and pregnancy outcome. Obstet Gynecol 1996;88:33–9.
  • 20. Takahashi J, Kado M, Mizumoto K, Igarashi S, Kojo T. Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography. Jpn J Ophthalmol 2013;57(5):435-9.
  • 21. Su L, Taweebanjongsin W, Gaw SL, Rabina G, Sadda SR, Tsui I. Evaluation of the Choroid in Women with Uncomplicated Pregnancy. Transl Vis Sci Technol 2020;9(9):24.
  • 22. Kara N, Sayin N, Pirhan D, Vural AD, Araz-Ersan HB, Tekirdag AI, et al. Evaluation of subfoveal choroidal thickness in pregnant women using enhanced depth imaging optical coherence tomography. Curr Eye Res 2014;39(6):642-7.
  • 23. Taradaj K, Ginda T, Maciejewicz P, Suchonska B, Wielgos M, Kecik D, et al. Does pregnancy influence eye parameters? Assessment of choroidal thickness using EDI-OCT before and after labour depending on the way of delivery method. Ginekol Pol 2020;91(11):668-73.

İntrauterin Gelişme Geriliği Olan Gebelerin Koroid Kalınlığının Optik Koherens Tomografi ile Değerlendirilmesi

Year 2021, , 395 - 399, 29.06.2021
https://doi.org/10.31832/smj.861550

Abstract

Amaç: İntrauterin gelişme geriliği olan gebelerde, sağlıklı gebelerde ve sağlıklı gebe olmayan kadınlarda optik koherens tomografi cihazı kullanılarak gözdeki koroid kalınlık ölçümünün karşılaştırması amaçlandı.
Gereç ve Yöntemler: Bu karşılaştırmalı çalışmaya Aralık 2016 ve Ocak 2018 tarihleri arasında üniversite hastanesinde gebe polikliniğine başvuran gebeler ve gebe olmayan sağlıklı kadınlar dahil edilmiştir. Çalışmaya 18-45 yaş aralığında, 31 üçüncü trimester sağlıklı gebe, 30 intrauterin gelişme geriliği olan gebe ve 30 sağlıklı gönüllü kadın katılmıştır. Çalışmaya katılan kişilerin koroid kalınlığı Enhanced Depth Imaging Optik Koherens Tomografi (EDI-OKT) yöntemiyle ölçülmüştür.
Bulgular: Çalışmaya alınan sağlıklı gebeler 33,6±3,2 hafta, intrauterin gelişme geriliği olan gebeler ise 34,2±2,8 hafta idi ve gebelik haftaları arasında anlamlı fark yoktu (p=0,420). Sağlıklı gebelerin koroid kalınlık ölçümü 357,27±59,25 μm, intrauterin gelişme geriliği olan gebelerin koroid kalınlık ölçümü 352,27±67,01 μm, sağlıklı kadınların ise 337,87±88,44 μm idi. Gruplar arasında koroid kalınlık ölçümü açısından anlamlı fark saptanmamıştır (p=0,559). Ayrıca sağlıklı gebeler ve intrauterin gelişme geriliği olan gebelerin arasında koroid kalınlık açısından fark bulunamamıştır (p=0,367).
Sonuç: İntrauterin gelişme geriliği olan gebelerin, sağlıklı gebelerin ve sağlıklı kadınların koroid kalınlık karşılaştırılmasında anlamlı bir farklılık bulunamamıştır.

References

  • 1. Errera MH, Kohly RP, da Cruz L. Pregnancy-associated retinal diseases and their management. Surv Ophthalmol 2013;58(2):127–42.
  • 2. Rhee P, Dev S, Mieler WF. The development of choroidal neovascularization in pregnancy. Retina 1999;19(6):520–4.
  • 3. Polizzi S, Mahajan VB. Intravitreal anti-VEGF injections in pregnancy: case series and review of literature. J Ocul Pharmacol Ther 2015;31(10):605–10.
  • 4. Pole C, Gaw Stephanie SL, Tsui Irena I. Utility of optical coherence tomography angiography in pregnancy-associated central serous chorioretinopathy. Am J Ophthalmol Case Rep 2020;20:100979.
  • 5. Yeoh J, Rahman W, Chen F, Hooper C, Patel P, Tufail A, et al. Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2010;248(12):1719-28.
  • 6. Spaide RF, Koizumi H, Pozonni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008;146(4):496-500.
  • 7. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 2009;147(5):811-5.
  • 8. Regatieri CV, Branchini L, Fujimoto JG, Duker JS. Choroidal imaging using spectral-domain optical coherence tomography. Retina 2012;32(5):865-76.
  • 9. Ferreira BFA, Kreuz AC, Diniz PM, Rocha JVSS, Pimentel SLG. Spontaneous outer retinal layer recovery in a case of hypertensive choroidopathy secondary to pre-eclampsia: a multimodal evaluation. Arq Bras Oftalmol 2019;82(6):522-7.
  • 10. Jiang MS, Xu XL, Yang T, Li F, Zhang XD. Comparison of Choroidal Thickness in Preeclamptic, Healthy Pregnant, and Nonpregnant Women: A Systematic Review and Meta-Analysis. Ophthalmic Res 2019;62(1):1-10.
  • 11. Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci 2010;51:2173–6.
  • 12. Agawa T, Miura M, Ikuno Y, Makita S, Fabritius T, Iwasaki T, et al. Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2011;249:1485–92.
  • 13. Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 2009;148:445–50.
  • 14. Nishida Y, Fujiwara T, Imamura Y, Lima LH, Kurosaka D, Spaide RF. Choroidal thickness and visual acuity in highly myopic eyes. Retina 2012;32:1229-36.
  • 15. Maruko I, Iida T, Sugano Y, Ojima A, Sekiryu T. Subfoveal choroidal thickness in fellow eyes of patients with central serous chorioretinopathy. Retina 2011;31(8):1603-8.
  • 16. Harada T, Machida S, Fujiwara T, Nishida Y, Kurosaka D. Choroidal findings in idiopathic uveal effusion syndrome. Clin Ophthalmol 2011;5:1599-601.
  • 17. Baltmr A, Lightman S, Tomkins-Netzer O. Vogt-Koyanagi-Harada syndrome - current perspectives. Clin Ophthalmol 2016;10:2345-61.
  • 18. Temel E, Kocamış Ö, Aşıkgarip N, Örnek K, Arıöz O. Evaluation of choroidal thickness and choroidal vascularity index during pregnancy. Can J Ophthalmol 2021:S0008-4182(20)30836-X.
  • 19. Whittaker PG, Macphail S, Lind T. Serial hematologic changes and pregnancy outcome. Obstet Gynecol 1996;88:33–9.
  • 20. Takahashi J, Kado M, Mizumoto K, Igarashi S, Kojo T. Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography. Jpn J Ophthalmol 2013;57(5):435-9.
  • 21. Su L, Taweebanjongsin W, Gaw SL, Rabina G, Sadda SR, Tsui I. Evaluation of the Choroid in Women with Uncomplicated Pregnancy. Transl Vis Sci Technol 2020;9(9):24.
  • 22. Kara N, Sayin N, Pirhan D, Vural AD, Araz-Ersan HB, Tekirdag AI, et al. Evaluation of subfoveal choroidal thickness in pregnant women using enhanced depth imaging optical coherence tomography. Curr Eye Res 2014;39(6):642-7.
  • 23. Taradaj K, Ginda T, Maciejewicz P, Suchonska B, Wielgos M, Kecik D, et al. Does pregnancy influence eye parameters? Assessment of choroidal thickness using EDI-OCT before and after labour depending on the way of delivery method. Ginekol Pol 2020;91(11):668-73.
There are 23 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Bayram Can This is me 0000-0002-3610-9089

Yunus Emre Purut 0000-0001-5779-3847

Burak Giray 0000-0002-3832-6634

Gülfidan Bitirgen 0000-0002-0509-5649

Ali Acar 0000-0002-9074-258X

Publication Date June 29, 2021
Submission Date January 21, 2021
Published in Issue Year 2021

Cite

AMA Can B, Purut YE, Giray B, Bitirgen G, Acar A. İntrauterin Gelişme Geriliği Olan Gebelerin Koroid Kalınlığının Optik Koherens Tomografi ile Değerlendirilmesi. Sakarya Tıp Dergisi. June 2021;11(2):395-399. doi:10.31832/smj.861550

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