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Mad honey poisoning accompanied by hypotension and bradycardia

Year 2011, Volume: 1 Issue: 2, 73 - 75, 01.06.2011
https://doi.org/10.5505/sakaryamj.2011.41636

Abstract

The honey which is produced in the Blacksea Region of Turkey,also known as the 'mad honey', includes a toxin which was named Andromedotoxin. The toxin causes not only gastrointestinal but also cardiovascular side effects. This toxin (Andrometoxin) is derived from R.Luteum and R. Panticum which are the two members of Rhododendron plant family. In this study, we aimed to present a patient with typical poisoning findings after consuming mad honey.

References

  • Gunduz A, Bostan H, Nuhoglu I, et al. Wild flowers and mad honey. Wilderness Environ Med 2007;18:69-71.
  • Gündüz A, Tatlı Ö, Türedi S. Geçmişten günüımüze deli bal zehirlenmesi. Turk J Emerg Med 2008;8:46-49.
  • Gündüz A, Turedi S, Uzun H, Topbas M. Mad hoıney poisoning. Am J Emerg Med 2006;24:595-8.
  • Terai T, Osakabe K, Katai M, et al. Preparation of 9- hydroxy grayanotoxin derivatives and their Acute toxicity in mice. Chem Pharm Bull 2003;51:351-3.
  • Koca I, Koca AF. Poisoning by mad honey: A briıef review. Food Chem Toxicol 2007;45:1315-8.
  • Gündüz A, Meriçé ES, Baydın A, et al. Does mad honey poisoning require hospital admission? Am J Emerg Med 2009;27:424-7.
  • Volkan H, Serhat B, Nihat K, Sami A, Serhan Y, Işıl ÖT. Zonguldak Bölgesinde Deli Bal Zehirlenmesi: Yetmiş İki Olgunun Analizi. Türk Anest Rean Der Dergisi 2010; 38(4):278-284.
  • Demircan A, Keleş A, Bildik F, Aygencel G, Doğan ON, Gómez HF. Mad honey sex: therapeutic misadventures from an ancient biological weapon. Ann Emerg Med 2009 Aug 15.
  • Özhan H, Akdemir R, Yazici M, Gündüz H, Duran S, Uyan C. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4.
  • Onat FY, Yegen BC, Lawrence R, Oktay A, Oktay S. Site of action of grayanotoxin in mad honey in rats. J Appl Toxicol 1991;11:199-201.
  • Maejima H, Kinoshita E, Seyama I, et al. Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensivity. J Biol Chem 2003;278:9464-71.
  • Yilmaz O, Eser M, Sahiner A, Altintop L, Yesilıdag O. Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 2006;68:405-8.
  • Yildirim N, Aydin M, Cam F, Celik O. Clinical preısentation of non-ST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26:108.e1-2.
  • Cetin N.G, Marcıl E, Kıldıran M, Ogüt S. Hepatotoxicity with mad honey Turk J Emerg Med 2009;9:84-86.
  • Dursunoglu D, Gur S, Semiz E. A case with complete atrioventricular block related to mad honey intoxication. Ann Emerg Med 2007;50:484-5. Yaylacı ve Ark.
  • Deli Bal Zehirlenmesi
  • Sakaryamj;2011(2):73-75

Hipotansiyon ve bradikardi etiyolojisinde deli bal zehirlenmesi

Year 2011, Volume: 1 Issue: 2, 73 - 75, 01.06.2011
https://doi.org/10.5505/sakaryamj.2011.41636

Abstract

Ülkemizde genel olarak Karadeniz bölgesinde üretilen ve deli bal olarak bilinen balda bulunan Grayanotoxin (Andromedotoxin) adlı toksinin, gastrointestinal sistem yan etkilerinin yanında kardiyovasküler sistem yan etkilerinin olduğu da bilinmektedir. Bu toksin Rhododendron cinsi bitkilerin iki üyesi olan R. Luteum ve R. Panticumdan üretilmektedir. Bu çalısmada, Karadeniz Bölgesinde üretilen balı yedikten sonra tipik zehirlenme bulguları ile klinigimize basvuran bir hastayı sunmayı amaçladık.

References

  • Gunduz A, Bostan H, Nuhoglu I, et al. Wild flowers and mad honey. Wilderness Environ Med 2007;18:69-71.
  • Gündüz A, Tatlı Ö, Türedi S. Geçmişten günüımüze deli bal zehirlenmesi. Turk J Emerg Med 2008;8:46-49.
  • Gündüz A, Turedi S, Uzun H, Topbas M. Mad hoıney poisoning. Am J Emerg Med 2006;24:595-8.
  • Terai T, Osakabe K, Katai M, et al. Preparation of 9- hydroxy grayanotoxin derivatives and their Acute toxicity in mice. Chem Pharm Bull 2003;51:351-3.
  • Koca I, Koca AF. Poisoning by mad honey: A briıef review. Food Chem Toxicol 2007;45:1315-8.
  • Gündüz A, Meriçé ES, Baydın A, et al. Does mad honey poisoning require hospital admission? Am J Emerg Med 2009;27:424-7.
  • Volkan H, Serhat B, Nihat K, Sami A, Serhan Y, Işıl ÖT. Zonguldak Bölgesinde Deli Bal Zehirlenmesi: Yetmiş İki Olgunun Analizi. Türk Anest Rean Der Dergisi 2010; 38(4):278-284.
  • Demircan A, Keleş A, Bildik F, Aygencel G, Doğan ON, Gómez HF. Mad honey sex: therapeutic misadventures from an ancient biological weapon. Ann Emerg Med 2009 Aug 15.
  • Özhan H, Akdemir R, Yazici M, Gündüz H, Duran S, Uyan C. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4.
  • Onat FY, Yegen BC, Lawrence R, Oktay A, Oktay S. Site of action of grayanotoxin in mad honey in rats. J Appl Toxicol 1991;11:199-201.
  • Maejima H, Kinoshita E, Seyama I, et al. Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensivity. J Biol Chem 2003;278:9464-71.
  • Yilmaz O, Eser M, Sahiner A, Altintop L, Yesilıdag O. Hypotension, bradycardia and syncope caused by honey poisoning. Resuscitation 2006;68:405-8.
  • Yildirim N, Aydin M, Cam F, Celik O. Clinical preısentation of non-ST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26:108.e1-2.
  • Cetin N.G, Marcıl E, Kıldıran M, Ogüt S. Hepatotoxicity with mad honey Turk J Emerg Med 2009;9:84-86.
  • Dursunoglu D, Gur S, Semiz E. A case with complete atrioventricular block related to mad honey intoxication. Ann Emerg Med 2007;50:484-5. Yaylacı ve Ark.
  • Deli Bal Zehirlenmesi
  • Sakaryamj;2011(2):73-75
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Selçuk Yaylacı This is me

Altuğ Ösken This is me

Serdar Olt This is me

Tayfun Temiz This is me

Ali Tamer This is me

Hüseyin Gündüz This is me

Publication Date June 1, 2011
Submission Date September 7, 2015
Published in Issue Year 2011 Volume: 1 Issue: 2

Cite

AMA Yaylacı S, Ösken A, Olt S, Temiz T, Tamer A, Gündüz H. Hipotansiyon ve bradikardi etiyolojisinde deli bal zehirlenmesi. Sakarya Tıp Dergisi. June 2011;1(2):73-75. doi:10.5505/sakaryamj.2011.41636

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