Prostatik Adenokarsinomlarda Triptaz ve Kimaz Ekspresyon Farklılıkları

Year 2018, Volume: 8 Issue: 2, 229 - 234, 29.06.2018

Ali Aslan Havva Erdem Hilal Balta Nilüfer Kadıoğlu Feyza Başar Handan Ankaralı

https://doi.org/10.31832/smj.383035

Cited By: 1

Abstract

Amaç: Mast
hücrelerinin (MCs) rolleri birçok tümörde çeşitli biyolojik süreçlerde
gösterilmiştir. MCs, artan anjiyogenez yoluyla tümör progresyonunda rol oynar.
Triptaz ve kimaz, mast hücre granüllerinde depolanır. Bu çalışmanın amacı,
prostat adenokarsinomalarında (PA) triptaz ve kimaz arasındaki ilişkiyi
araştırmaktır.

Gereç
ve Yöntem: Bu çalışma, 2012-2014 yılları arasında Tıp
Fakültesi Hastanesi Patoloji Bölümü'nde histopatolojik olarak PA tanısı alan
134 hastanın parafine gömülü numunesinde yürütülmüştür. Parafine gömülü PA
numuneleri 3 μm kalınlığında kesilmiştir. Kesitler triptaz ve kimaz ile boyanmıştır.

Bulgular:
Mast
Hücre Kimazının (MCC), intratümöral bölgelerde peritümöral bölgelere göre daha çok
biriktiği gözlenmiştir (sırasıyla ortalama: 14,28 ± 14,06, ortalama: 12,12 ±
12,56). Mast Hücre Triptazı (MCT), intratümöral ve peritümöral bölgelerde MCC'den
daha fazla birikmiştir (P<0,001). MCT’nin, peritümöral bölgelerde,
intratümöral bölgelere göre daha fazla biriktiği gözlenmiştir (sırasıyla; 33.94
± 20.09, ortalama: 33,50 ± 18,65). MCT ve MCC’nin intratümöral alan ve
peritümöral alanla ilişkisi karşılaştırıldı. MCT’de anlamlı fark yoktu (p=0.723).
Bununla birlikte, MCC intratümöral alanda peritümöral alandan daha fazla
bulundu (p=0.007).

Sonuç:
Mast
hücreleri PA için önemli bir rol oynayabilir. Malign progresyonda MCC, MCT'den
daha önemli olabilir.

Keywords

Triptaz, kimaz, prostatik adenokarsinomlar

Tryptase and Chymase Expression Differences in Prostatic Adenocarsinomas

Abstract

Abstract

Objective: The
roles of mast cells (MCs)  have been
demonstrated in various biologic processes in the many tumors. MCs play some
roles in tumor progression via increasing angiogenesis. Tryptase and chymase
are stored in the mast cell granules. The aim of this study was to investigate the
relationship of tryptase and chymase in
prostatic adenocarcinomas (PA).

Materials and Methods: This study was conducted on a
total of 134 paraffin-embedded PA
samples, which were histopathologically diagnosed at the Department of
Pathology of medicine Hospital between 2012 and 2014. Paraffin-embedded PA samples 3 μm
in thickness, were then cut. The slides were stained with tryptase and chymase.

Result: Mast
Cell Chymase (MCC) was observed that intratumoral areas more acumulate than
peritumoral areas (respectively; mean: 14,28 ± 14,06, mean: 12,12 ± 12,56).
Mast Cell Tryptase (MCT) was more acumulated than MCC in intratumoral and
peritumoral areas (P<0,001). MCT was observed that peritumoral areas more acumulate
than intratumoral areas (respectively; mean: 33,94 ± 20,09, mean: 33,50 ± 18,65).
MCT and MCC compared with regard to intratumoral area and peritumoral area.
There wasn’t significant difference with MCT (p=0.723). However, MCC was found
intratumoral area more than peritumoral area (p=0.007).

Conclusion: Mast
cells may play an important role for PA. MCC might be more important than MCT in malignant progression.

Keywords

Tryptase, chymase, prostatic adenocarcinomas

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