Kronik Kolesistit Hastalarında Safra Kesesi IGF-1 Ekspresyonunun Biyokimyasal Parametrelerle İlişkisi

Year 2018, Volume: 8 Issue: 4, 782 - 787, 30.12.2018

Ali Aslan Havva Erdem Yasemin Kaya Soner Çankaya

https://doi.org/10.31832/smj.459594

Abstract

Amaç: Bu araştırmada,
çeşitli biyokimyasal parametreler ve safra kesesi IGF-1 ekspresyonu arasındaki
ilişki biyokimyasal ve patolojik yöntemlerle incelenmiştir.

Gereç
ve Yöntemler: 1 Ocak 2017- 31 Ocak 2018 tarihleri arasında
Ordu Eğitim Araştırma Hastanesi’nde kronik kolesistit tanısı alan hastalara ait
tıbbi kayıtlar retrospektif olarak incelendi. Hastaların çeşitli biyokimyasal
parametreleri çalışıldı. Kronik kolesistit nedeniyle opere edilen hastalardan
elde edilen kolesistektomi materyalinde immünhistokimyasal yöntemle IGF-1
antikoru uygulandı.

Bulgular: Patolojik
incelemede IGF-1 ekspresyonunun izlendiği gruptaki en belirgin biyokimyasal
değer CRP yüksekliği olarak saptandı.

Sonuç: Safra kesesi IGF-1
ekspresyonu ve inflamasyon ilişkisini düşündüren bu bulguların farklı
yöntemlerle doğrulanması kronik kolesistit gelişimi ve kolesistit-kanser
ilişkisi üzerine yeni ufuklar açabilir.  

Keywords

Kronik kolesistit, obezite, IGF-1 immunohistokimya, CRP

The Relation Among Biochemical Parameters and Gallbladder IGF-1 Expression in Patients with Chronic Cholecystitis

Abstract

Aim: In the present study, the relation between certain biochemical parameters and gallbladder IGF-1 expression was investigated with pathological and biochemical methods.

Material and Methods: The records of patients who administrated to Ordu Education and Research Hospital between 1 January 2017-31 January 2018 with the diagnosis of chronic cholecystitis were examined retrospectively. Certain biochemical parameters of the patients were studied. In addition, IGF-1 antibody was applied to cholecystectomy specimens with the immunohistochemical method.

Results: In the pathological evaluation, the group exhibiting positive IGF-1 staining showed high CRP values.

Conclusion: Future confirmation of these findings of IGF-1 expression and inflammation connection could lead new directions through cholecystitis development and cholecystitis-cancer link. 

Keywords

Chronic cholecystitis, obesity, IGF immunohistochemistry, CRP

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