Evaluation of the Serum Zinc, Selenium, Manganese, Iron, Copper Element Levels, and Cu/Zn, Cu/Fe, Cu/Mn, Fe/Zn, Fe/Se, Fe/Mn Ratios in Type 2 Diabetes Mellitus Patients

Year 2019, Volume: 9 Issue: 1, 38 - 45, 20.03.2019

Nurten Bahtiyar , Yalçın Hacıoğlu

https://doi.org/10.31832/smj.511680

Cited By: 1

Abstract

Objective The aim of this study was to investigate the role of serum zinc (Zn) and copper (Cu) selenium (Se), manganese (Mn) and iron (Fe) levels and ratios, and their role in the pathogenesis of Type
2 Diabetes Mellitus (T2DM). ( Sakarya Med J 2019, 9(1):38-45 )
Materials and
Methods 70 T2DM and 40 healthy subjects were included in the study. Serum Zn, Cu, Se, Mn and Fe levels of all individuals were measured by inductively coupled plasma optical emission spectrophotometry (ICP-OES).
Results Serum Zn, Se, Mn levels were significantly decreased in T2DM group compared to the control group (p<0.01, p<0.001, p<0.01, respectively). Cu and Fe values were significantly increased
in T2DM group compared to the control group (p<0.001 p<0.05, respectively). In the T2DM group, Cu/Zn, Cu/Se, Cu/Mn ratios were found to be statistically higher than the control group
(p<0.001 for all). Also, Fe/Zn, Fe/Se, Fe/Mn ratios were found to be statistically higher than the control group (p<0.01 for all). There were the highest positive correlations betweeen Cu and
Cu/Zn; Fe and Fe/Zn; Fe/Se and Fe/Mn; Fe/Se and Fe/Mn; Fe/Mn and Cu/Mn in T2DM group. Also, there were the highest negative correlations between Zn and Cu/ Zn; Mn and Fe/Mn, and
Cu/Mn; Se and Cu/Se.
Conclusion When we examine the findings of our study, it shows that trace elements are involved in the pathogenesis of T2DM. Further studies are needed to determine the associated mechanisms of trace
element levels and ratios in T2DM disease.

Keywords

Type 2 Diabetes Mellitus, Zinc, Selenium, Manganese, Copper, Iron

Tip 2 Diabetes Mellitus Hastalarında Serum Çinko, Selenyum, Mangan, Demir, Bakır Element Düzeyleri ve Cu/Zn, Cu/Se, Cu/Mn, Fe/Zn, Fe/Se, Fe/Mn Oranlarının Değerlendirilmesi

Abstract

Amaç: Çalışmamızda Tip 2 Diabetes Mellitus (T2DM) hastalarında çinko (Zn) ve
bakır (Cu) selenyum (Se), mangan (Mn) ve demir (Fe) eser elementlerinin serum
düzeyleri ve oranlarındaki olası değişimi ve hastalık
patogenezindeki rolleri araştırılmıştır.

Gereç
ve Yöntem: Çalışmaya 70
T2DM ve 40 sağlıklı birey dahil edilmiştir. Tüm bireylere ait serum Zn, Cu, Se,
Mn ve Fe düzeyleri indüktif eşleşmiş plazma optik emisyon spektrofotometresi
(ICP-OES) ile ölçülmüştür.

Bulgular: Serum Zn, Se, Mn düzeylerinin T2DM grubunda
kontrol grubuna göre anlamlı derecede azaldığı belirlendi (sırasıyla p<0,01, p<0,001,
p<0,01). Cu ve Fe değerlerinin ise T2DM grubunda kontrol grubuna
göre istatistiksel olarak anlamlı derecede arttığı belirlendi (sırasıyla p<0,001 p<0,05).
T2DM grubunda Cu/Zn, Cu/Se, Cu/Mn oranları kontrol grubundan istatistiksel
olarak daha yüksek olduğu bulundu (hepsi için p <0,001). Ayrıca, Fe/Zn,
Fe/Se, Fe/Mn oranları kontrol grubundan istatistiksel olarak daha yüksek olduğu
gözlendi (hepsi için p <0,01).

Sonuç:
Çalışmamızın bulgularını
incelediğimizde eser elementlerin T2DM patogenezinde yer aldığını
göstermektedir. T2DM hastalığında eser element seviyelerinin ve oranlarının
ilişkili mekanizmalarını belirlemek için ileri çalışmalara ihtiyaç vardır.

Keywords

Tip 2 Diabetes Mellitus, Çinko, Selenyum, Mangan, Demir, Bakır

References

• 1. Karahan SC, Değer O, Örem A, Uçar F, Erem C, Alver A et al. The effects of impaired trace element status on polymorphonuclear leukocyte activation in the development of vascular complications in type 2 diabetes mellitus. Clinical chemistry and laboratory medicine 2001; 39(2): 109-115.
• 2. Dulal H, Lamsal M, Sharma S, Baral N, Majhi S. Status of iron, oxidant and antioxidants in chronic type 2 Diabetes mellitus patients. Nepal Med Coll J 2013; 15(3): 208-211.
• 3. Organization WH. Global report on diabetes, World Health Organization, 2016.
• 4. Walter RM, Uriu-Hare JY, Olin KL, Oster MH, Anawalt BD, Critchfield JW et al. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes care 1991; 14(11): 1050-1056.
• 5. de Vega RG, Fernández-Sánchez ML, Fernández JC, Menéndez FVÁ, Sanz-Medel A. Selenium levels and glutathione peroxidase activity in the plasma of patients with type II diabetes mellitus. Journal of Trace Elements in Medicine and Biology 2016; 37: 44-49.
• 6. Basaki M, Saeb M, Nazifi S, Shamsaei H. Zinc, copper, iron, and chromium concentrations in young patients with type 2 diabetes mellitus. Biological Trace Element Research 2012; 148(2): 161-164.
• 7. Cinemre FBS, Bahtiyar NB, Ertan E, Değirmencioğlu S, Dilaveroğlu N, Çakar AE et al. Hashimoto Tiroiditli Hastalarda Bakır, Demir, Çinko, Selenyum düzeyleri ve Cu/Se, Cu/Zn, Fe/Se, Fe/Zn Oranlarının Araştırılması. Sakarya Tıp Dergisi; 8(2): 285-291.
• 8. Sanjeevi N, Freeland-Graves J, Beretvas SN, Sachdev PK. Trace element status in type 2 diabetes: A meta-analysis. Journal of clinical and diagnostic research: JCDR 2018; 12(5): OE01.
• 9. Zargar AH, Shah NA, Masoodi SR, Laway BA, Dar FA, Khan AR et al. Copper, zinc, and magnesium levels in non-insulin dependent diabetes mellitus. Postgraduate medical journal 1998; 74(877): 665-668.
• 10. Jiang R, Ma J, Ascherio A, Stampfer MJ, Willett WC, Hu FB. Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. The American journal of clinical nutrition 2004; 79(1): 70-75.
• 11. Hansen AF, Simić A, Åsvold BO, Romundstad PR, Midthjell K, Syversen T et al. Trace elements in early phase type 2 diabetes mellitus—A population-based study. The HUNT study in Norway. Journal of Trace Elements in Medicine and Biology 2017; 40: 46-53.
• 12. Faure P. Protective effects of antioxidant micronutrients (vitamin E, zinc and selenium) in type 2 diabetes mellitus. Clinical chemistry and laboratory medicine 2003; 41(8): 995-998.
• 13. Evliyaoğlu O, Kebapçılar L, Uzuncan N, Kılıçaslan N, Karaca B, Kocaçelebi R et al. Correlations of Serum Cu, Zn, Mg and HbA 1c in Type 2 and Type 2 Diabetes Mellitus. Turkish Journal of Endocrinology and Metabolism 2004; 2: 75-79.
• 14. Pujar S, Pujar L, Ganiger A, Hiremath K, Mannangji N, Bhuthal M. Correlation of serum zinc, Magnesium, and copper with HbA1c in type 2 diabetes mellitus patients among Bagalkot population-A case control study. Med Innovatica 2014; 3: 4-8.
• 15. Yeasmin R, Muttalib M, Sultana N, Bhuiyan NH, Alam R. Status of some Trace Elements in Type-2 Diabetic Patients and its Relationship with Lipid Profile. Journal of Bangladesh Academy of Sciences 2016; 40(1): 79-85.
• 16. Terres-Martos C, Navarro-Alarcon M, Martin-Lagos F, De La Serrana HL-G, Perez-Valero V. Serum zinc and copper concentrations and Cu/Zn ratios in patients with hepatopathies or diabetes. Journal of trace elements in medicine and biology 1998; 12(1): 44-49.
• 17. Atari-Hajipirloo S, Valizadeh N, Khadem-Ansari M-H, Rasmi Y, Kheradmand F. Altered concentrations of copper, zinc, and iron are associated with increased levels of glycated hemoglobin in patients with type 2 diabetes mellitus and their first-degree relatives. International journal of endocrinology and metabolism 2016; 14(2).
• 18. Ekmekcioglu C, Prohaska C, Pomazal K, Steffan I, Schernthaner G, Marktl W. Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls. Biological Trace Element Research 2001; 79(3): 205-219.
• 19. Yerlikaya FH, Toker A, Arıbaş A. Serum trace elements in obese women with or without diabetes. The Indian journal of medical research 2013; 137(2): 339.
• 20. Farid SM. Correlation between serum trace elements and lipids in patients with type 2 diabetes mellitus in Jeddah, Saudi Arabia. Global Journal of Bio-science and biotechnology 2016; 5(3): 311-317.
• 21. Tamrakar S, Kachhawa K, Agrawal D, Varma M, Swain T, Kumar S. Study of trace elements (Mg and Cu) and dyslipidemia in type 2 diabetes mellitus (T2DM) patients presenting in a tertiary care hospital of South East Asia. Int J Curr Res 2016; 8: 26972-26975.
• 22. Hussain F, Maan MA, Sheikh MA, Nawaz H, Jamil A. Trace elements status in type 2 diabetes. Bangladesh journal of medical science 2009; 8(3): 52-56.
• 23. Ekin S, Mert N, Gunduz H, Meral I. Serum sialic acid levels and selected mineral status in patients with type 2 diabetes mellitus. Biological trace element research 2003; 94(3): 193-201.
• 24. Masood N, Baloch GH, Ghori RA, Memon IA, Memon MA, Memon MS. Serum zinc and magnesium in type-2 diabetic patients. J Coll Physicians Surg Pak 2009; 19(8): 483-486.
• 25. Quilliot D, Dousset B, Guerci B, Dubois F, Drouin P, Ziegler O. Evidence that diabetes mellitus favors impaired metabolism of zinc, copper, and selenium in chronic pancreatitis. Pancreas 2001; 22(3): 299-306.
• 26. Zheng Y, Li X-K, Wang Y, Cai L. The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators. Hemoglobin 2008; 32(1-2): 135-145.
• 27. Viktorinova A, Tošerová E, Križko M, Ďuračková Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism 2009; 58(10): 1477-1482.
• 28. Eva H, Akhter QS, Alam MK. Serum zinc and manganese levels in subjects with type 2 diabetes mellitus. Journal of Bangladesh Society of Physiologist 2016; 11(2): 50-53.
• 29. Kornhauser C, Garcia-Ramirez JR, Wrobel K, Pérez-Luque E-L, Garay-Sevilla M-E, Wrobel K. Serum selenium and glutathione peroxidase concentrations in type 2 diabetes mellitus patients. Primary Care Diabetes 2008; 2(2): 81-85.