Tüberküloz ve D Vitamini Arasındaki İlişkinin Değerlendirilmesi: Güncel Yaklaşımlar

Year 2019, Volume: 9 Issue: 4, 565 - 573, 16.12.2019

Yücel Büyükdere , Aylin Ayaz

https://doi.org/10.31832/smj.549164

Abstract

D vitamini güneş
ışınları aracılığıyla deride sentezlenen ve iskelet sistemi üzerinde olumlu
etkileri bulunan steroid yapıda bir hormondur. D vitamininin bağışıklık sistemi
üzerindeki rolü, bağışıklık hücrelerinde D vitamini reseptörlerinin belirlenmesi
ve makrofajlar, monositler ile aktive edilmiş T hücreleri gibi bağışıklık
hücrelerinde D vitamininin aktif formunun tanımlanmış olmasıyla saptanmıştır. D
vitamini, katelisidin ve defensin gibi antimikrobiyal peptidlerin salınımını
artırarak, otofajiyi uyararak, Toll benzeri reseptörlerin sinyalizasyonunu
değiştirerek, anti-inflamatuvar sitokinlerin salınımını artırarak ve dendritik
hücrelerle T ve B lenfositlerin regülasyonunu sağlayarak doğal ve kazanılmış
bağışıklık sistemini modüle etmektedir. Mycobacterium
tuberculosis etkeninin sebep olduğu sistemik bir bakteriyel enfeksiyon olan
tüberküloza karşı, D vitamini bu mekanizmalarla olumlu etki göstermektedir. Bu
derlemede D vitamininin tüberküloz hastalığı üzerindeki etkilerinin son güncel
literatür verilerine göre incelenmesi amaçlanmıştır.

Keywords

Bağışıklık, D vitamini, enfeksiyon

Evaluation of the Association Between Tuberculosis and Vitamin D: Current Approaches

Abstract

Vitamin D is a steroid hormone synthesized in
the skin through sunlight and has positive effects on skeletal system. The role
of vitamin D on the immune system have been demonstrated with the detection of
vitamin D receptors in immune cells and the discovery that vitamin D can be
converted into active form in immune cells such as macrophages, monocytes,
activated T cells. Vitamin D modulates the innate and adapted immune system by
increasing the release of antimicrobial peptides such as cathelicidine and
defensin, stimulating autophagy, modifying Toll-like receptor signaling,
increasing the release of anti-inflammatory cytokines and regulating dendritic
cells, T and B lymphocytes. Against tuberculosis, a systemic bacterial infection
caused by Mycobacterium tuberculosis,
vitamin D has a positive effect through these mechanisms. In this review, the
effects of vitamin D on tuberculosis are aimed to be analyzed according to the
latest current literature.

Keywords

Immunity, Vitamin D, infection, tuberculosis

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