Diyetle K Vitamini Alımı Bilişsel Performansı Etkiler mi?

Year 2020, Volume: 10 Issue: 1, 162 - 170, 16.03.2020

Aysegul Ugural , Aylin Ayaz

https://doi.org/10.31832/smj.583473

Abstract

K
vitamini yağda çözünen bir vitamin olup doğada filokinon (K1) ve menakinon (K2)
formlarında bulunmaktadır. Menadion (K3) formu ise sentetik analog olarak kullanılmaktadır.
K vitamini, metabolizmada K vitaminine bağımlı proteinlerin karboksilasyonundan
sorumludur. Genellikle kan koagülasyonü üzerine rolü olduğu bilinen K
vitamininin günümüzde kardiyovasküler hastalıklar, osteoporoz, vasküler
kalsifikasyon, kanser, diyabet ve glisemik kontrol ile de ilişkisi olduğu
gösterilmiştir. Son yıllarda ise beyinde miyelinizasyonun yoğun olduğu
bölgelerde Menakinon-4 (MK-4) formunda bulunduğu saptanmış ve bilişsel
performans ile bazı nörodejeneratif hastalıkların patogenezinde rol alabileceği
belirtilmiştir. Bu etkisini Gas-6 ve protein S gibi proteinler aracılığıyla
veya nöronları oksidatif stres hasarına karşı koruyarak gösterdiği
düşünülmektedir. Atriyal fibrilasyon (AF) hastalarının sıklıkla kullandığı
antikoagülanların ve K vitamini antagonisti olmayan antikoagülanların bilişsel
performans ve demans üzerine etkisi ise tartışmalıdır. Bu derleme makalede K
vitamini ve antikoagülanların bilişsel performans üzerine etkileri ele
alınmıştır.    

Keywords

K vitamini, bilişsel performans, Alzheimer, antikoagülanlar

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