Research Article
BibTex RIS Cite

Erzincan Mengücek Gazi Eğitim ve Araştırma Hastanesi’nde 2010-2018 Yılları Arasında Tanı Alan Erişkin Çölyak Hastalarının Değerlendirilmesi

Year 2020, Volume: 10 Issue: 1, 37 - 43, 16.03.2020
https://doi.org/10.31832/smj.634047

Abstract

Amaç: Erzincan Mengücek Gazi Eğitim ve Araştırma
Hastanesi’nde 2010-2018 yılları arasında tanı alan 18 yaş üstü erişkin Çölyak hastalarını
değerlendirmek. Gereç ve Yöntemler:
Klinik endikasyon sebebiyle hastanede duodenum
biyopsisi yapılan 652 hastadan Çölyak hastalığı bulguları izlenen ve hastaneden
Çölyak hastalığı raporu alan 54 erişkin hasta retrospektif olarak çalışmaya
dahil edildi. Patoloji laboratuarımızın arşivinde bulunan doku gömülü parafin
bloklardan 4 mikron kalınlığında kesitler alındı. Bu kesitler
Hematoksilen-Eozin boyası ile boyanarak patoloji preparatları hazırlandı ve Modifiye Marsh-Oberhuber sınıflaması kullanılarak değerlendirildi.
Bulgular: Çalışmamızda 54 hastanın 36’sı (%66,66) kadın, 18’i (%33,33)
erkekti. Yaş aralığı 18-65 idi. Bu aralık kadınlarda 18-59, erkeklerde 18-65
idi. Yaş ortalaması 39,48 olup kadınlarda 36,80, erkeklerde 44,83 idi.
Hastaların 2’sinde (%3,70) evre 1, 5’inde (%9,25)  evre 2, 9’unda (%16,66)  evre 3a, 34’ünde (%62,90) evre 3b ve 4’ünde
(%7,40) evre 3c izlendi. Hastalarda evre 4 izlenmedi. Sonuç: Çölyak hastalığının erken teşhisinin ve
uygun tedavisinin hayat kalitesini artıracağından dolayı, özellikle sebebi
belirlenemeyen malabsorbsiyon bulguları gibi gastrointestinal sistem ve ağrı
başta olmak üzere gastrointestinal sistem dışı şikayetleri olan hastalarda bu
şikayetlerin arkasında Çölyak hastalığının bulunabileceğinin göz ardı edilmemesi
gerekir.

References

  • 1. Theethira TG, Dennis M. Celiac Disease and the Gluten-Free Diet: Consequences and Recommendations for Improvement. Dig Dis 2015;33(2):175-182.
  • 2. Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease. Am J Gastroenterol 2018;108(5):656-676.
  • 3. Karaahmet F. Çölyak Hastalığında Teşhis Süresi. Length of Diagnosis in Celiac Disease. Ege Tıp Dergisi/Ege Journal of Medicine 2018;57(4):228-231.
  • 4. İşleroğlu H, Dirim SN, Ertekin FK. Gluten İçermeyen Hububat Esaslı Alternatif Ürün Formülasyonları ve Üretim Teknolojileri. Derleme / Review. GIDA2009;34(1):29-36.
  • 5. Serra S, Jani PA. An Approach to Duodenal Biopsies. J Clin Pathol 2006;59(11):1133-1150.
  • 6. Catassi C, Fabiani E, Corrao G, Renzo A, Carella AM, Gabrielli A et al. Risk of Non-Hodgkin Lymphoma in Celiac Disease. JAMA The Journal of the American Medical Association 2002;287(11):1413-1419.
  • 7. Harris LA, Park JY, Voltaggio L, Lam-Himlin D. Celiac Disease: Clinical, Endoscopic, and Histopathologic Review. Gastrointest Endosc 2012;76(3):625-640.
  • 8. Farell RJ, Kelly CP. Celiac Sprue. New England Journal of Medicine 2002;346(3):180-188.
  • 9. Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G. HLA-DQ and Risk Gradient for Celiac Disease. Hum Immunol 2009;70(1):55-59.
  • 10. Hin H, Bird G, Fisher P, Mahy N, Jewell D. Coeliac Disease in Primary Care: Case Finding Study. BMJ 1999;318(7177):164-167.
  • 11. Holmes GKT, Moor F. To Determine The Age and Gender of Patients With Coeliac Disease 1958–2008 in a Single Centre. Gut 2011;60: Issue Suppl 1.http://dx.doi.org/10.1136/gut.2011.239301.175
  • 12. Gujral N, Freeman HJ, Thomson ABR. Celiac Disease: Prevalence, Diagnosis, Pathogenesis and Treatment. World J Gastroenterol 2012;18(42):6036-6059.
  • 13. Daniel A. Leffler, Ciaran P. Kelly. Çölyak Hastalığının Değerlendirilmesi Ve Tanısı İle İlgili Bir Güncelleme. Current Opinion in Allergy and Clinical Immunology 2006;1(2):69-77.
  • 14. Elsurer R, Tatar G, Şimşek H, Balaban YH, Aydinli M, Sokmensuer C. Celiac Disease in the Turkish Population. Dig Dis Sci 2005;50(1):136-142.
  • 15. Cummins AG, Roberts-Thomson, IC. Prevalence of Celiac Disease in the Asia-Pacific region. Journal of Gastroenterology and Hepatology 2009;24(8):1347-1351.
  • 16. Haubrich WS, Schaffner F, Berk JE (eds). Bockus Gastroenterology, 5th. ed. Philadelphia: WB Saunders;1995.Chapter 59.p.1027-1046.
  • 17. Bürgin-Wolff A, Gaze H, Hadziselimovic F, Huber H, Lentze MJ, Nusslé D, et al. Antigliadin and Antiendomysium Antibody Determination for Coeliac Disease. Arch Dis Child 1991;66(8):941-947.
  • 18. Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabó IR, Sarnesto A, et al. Tissue Transglutaminase Autoantibody Enzyme-linked Immunosorbent Assay in Detecting Celiac Disease. Gastroenterology 1998;115(6):1322-1328.
  • 19. Husby S, Murray JA, Katzka DA. AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease: Changing Utility of Serology and Histologic Measures: Expert Review. Gastroenterology 2019;156(4):885-889.
  • 20. Dewar D, Pereira SP, Ciclitira PJ. The Pathogenesis of Coeliac Disease. Int J Biochem Cell Biol 2004;36(1):17-24.
  • 21. Rodrigo L. Celiac Disease. World J Gastroenterol 2006;12(41):6577-6584.
  • 22. Dogan IS, Yildiz O, Meral R. Optimization of Corn, Rice and Buck wheat Formulations for Gluten-Free Wafer Production. Food Sci Technol Int 2016;22(5):410-419. 23. Husby S, Bai JC. Follow-up of Celiac Disease. Gastroenterol Clin North Am 2019;48(1):127-136.
  • 24. Marsh MN. Gluten, Major Histocompatibility Complex, and the Small Intestine. A Molecular and Immunobiologic Approach to the Spectrum of Gluten Sensitivity (Celiac Sprue) Gastroenterology 1992;102(1):330-354.
  • 25. Oberhuber G, Granditsch G, Vogelsang H. The Histopathology of Coeliac Disease: Time for a Standardized Report Scheme for Pathologists. Eur J Gastroenterol Hepatol 1999;11(10):1185-1194.
  • 26. Corazza GR, Villanacci V. Coeliac Disease. J Clin Pathol 2005;58(6):573-574.
  • 27. Ensari A.Gluten-Sensitive Enteropathy (Celiac Disease): Controversies in Diagnosis and Classification. Arch Pathol Lab Med 2010;134(6),826-836.
  • 28. Taavela J, Kurppa K, Collin P, Lähdeaho ML, Salmi T, Saavalainen P, et al. Degree of Damage to the Small Bowel and Serum Antibody Titers Correlate with Clinical Presentation of Patients with Celiac Disease. Clin Gastroenterol Hepatol 2013;11(2):166-171.
  • 29. Marsh MN, Heal CJ. Review Evolutionary Developments in Interpreting the Gluten-Induced Mucosal Celiac Lesion: An Archimedian Heuristic. Nutrients 2017;9(3):213.
  • 30. Çakmak A. Ankara'da Yaşayan 19-65 Yaş Arası Çölyak Hastalarının Beslenme Durumlarının Yaşam Kalitesi Üzerine Etkisi. Hacettepe Üniversitesi Sağlık Bilimleri Enstitüsü, Diyetetik Programı Yüksek Lisans Tezi, Ankara,2013.s.46-47.
  • 31. Prasad KK, Thapa BR, Nain CK, Singh K. The Frequency of Histologic Lesion Variability of The Duodenal Mucosa in Children With Celiac Disease.World J Pediatr 2010;6(1):60-64.
  • 32. Gupta P, Chhabra S, Singh S, Malhotra P, Sen R. A Study of Clinical, Serological and Histopathological Profile in Celiac Disease. International Journal of Current Research 2016;8(9):39403-39408.
Year 2020, Volume: 10 Issue: 1, 37 - 43, 16.03.2020
https://doi.org/10.31832/smj.634047

Abstract

References

  • 1. Theethira TG, Dennis M. Celiac Disease and the Gluten-Free Diet: Consequences and Recommendations for Improvement. Dig Dis 2015;33(2):175-182.
  • 2. Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease. Am J Gastroenterol 2018;108(5):656-676.
  • 3. Karaahmet F. Çölyak Hastalığında Teşhis Süresi. Length of Diagnosis in Celiac Disease. Ege Tıp Dergisi/Ege Journal of Medicine 2018;57(4):228-231.
  • 4. İşleroğlu H, Dirim SN, Ertekin FK. Gluten İçermeyen Hububat Esaslı Alternatif Ürün Formülasyonları ve Üretim Teknolojileri. Derleme / Review. GIDA2009;34(1):29-36.
  • 5. Serra S, Jani PA. An Approach to Duodenal Biopsies. J Clin Pathol 2006;59(11):1133-1150.
  • 6. Catassi C, Fabiani E, Corrao G, Renzo A, Carella AM, Gabrielli A et al. Risk of Non-Hodgkin Lymphoma in Celiac Disease. JAMA The Journal of the American Medical Association 2002;287(11):1413-1419.
  • 7. Harris LA, Park JY, Voltaggio L, Lam-Himlin D. Celiac Disease: Clinical, Endoscopic, and Histopathologic Review. Gastrointest Endosc 2012;76(3):625-640.
  • 8. Farell RJ, Kelly CP. Celiac Sprue. New England Journal of Medicine 2002;346(3):180-188.
  • 9. Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G. HLA-DQ and Risk Gradient for Celiac Disease. Hum Immunol 2009;70(1):55-59.
  • 10. Hin H, Bird G, Fisher P, Mahy N, Jewell D. Coeliac Disease in Primary Care: Case Finding Study. BMJ 1999;318(7177):164-167.
  • 11. Holmes GKT, Moor F. To Determine The Age and Gender of Patients With Coeliac Disease 1958–2008 in a Single Centre. Gut 2011;60: Issue Suppl 1.http://dx.doi.org/10.1136/gut.2011.239301.175
  • 12. Gujral N, Freeman HJ, Thomson ABR. Celiac Disease: Prevalence, Diagnosis, Pathogenesis and Treatment. World J Gastroenterol 2012;18(42):6036-6059.
  • 13. Daniel A. Leffler, Ciaran P. Kelly. Çölyak Hastalığının Değerlendirilmesi Ve Tanısı İle İlgili Bir Güncelleme. Current Opinion in Allergy and Clinical Immunology 2006;1(2):69-77.
  • 14. Elsurer R, Tatar G, Şimşek H, Balaban YH, Aydinli M, Sokmensuer C. Celiac Disease in the Turkish Population. Dig Dis Sci 2005;50(1):136-142.
  • 15. Cummins AG, Roberts-Thomson, IC. Prevalence of Celiac Disease in the Asia-Pacific region. Journal of Gastroenterology and Hepatology 2009;24(8):1347-1351.
  • 16. Haubrich WS, Schaffner F, Berk JE (eds). Bockus Gastroenterology, 5th. ed. Philadelphia: WB Saunders;1995.Chapter 59.p.1027-1046.
  • 17. Bürgin-Wolff A, Gaze H, Hadziselimovic F, Huber H, Lentze MJ, Nusslé D, et al. Antigliadin and Antiendomysium Antibody Determination for Coeliac Disease. Arch Dis Child 1991;66(8):941-947.
  • 18. Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabó IR, Sarnesto A, et al. Tissue Transglutaminase Autoantibody Enzyme-linked Immunosorbent Assay in Detecting Celiac Disease. Gastroenterology 1998;115(6):1322-1328.
  • 19. Husby S, Murray JA, Katzka DA. AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease: Changing Utility of Serology and Histologic Measures: Expert Review. Gastroenterology 2019;156(4):885-889.
  • 20. Dewar D, Pereira SP, Ciclitira PJ. The Pathogenesis of Coeliac Disease. Int J Biochem Cell Biol 2004;36(1):17-24.
  • 21. Rodrigo L. Celiac Disease. World J Gastroenterol 2006;12(41):6577-6584.
  • 22. Dogan IS, Yildiz O, Meral R. Optimization of Corn, Rice and Buck wheat Formulations for Gluten-Free Wafer Production. Food Sci Technol Int 2016;22(5):410-419. 23. Husby S, Bai JC. Follow-up of Celiac Disease. Gastroenterol Clin North Am 2019;48(1):127-136.
  • 24. Marsh MN. Gluten, Major Histocompatibility Complex, and the Small Intestine. A Molecular and Immunobiologic Approach to the Spectrum of Gluten Sensitivity (Celiac Sprue) Gastroenterology 1992;102(1):330-354.
  • 25. Oberhuber G, Granditsch G, Vogelsang H. The Histopathology of Coeliac Disease: Time for a Standardized Report Scheme for Pathologists. Eur J Gastroenterol Hepatol 1999;11(10):1185-1194.
  • 26. Corazza GR, Villanacci V. Coeliac Disease. J Clin Pathol 2005;58(6):573-574.
  • 27. Ensari A.Gluten-Sensitive Enteropathy (Celiac Disease): Controversies in Diagnosis and Classification. Arch Pathol Lab Med 2010;134(6),826-836.
  • 28. Taavela J, Kurppa K, Collin P, Lähdeaho ML, Salmi T, Saavalainen P, et al. Degree of Damage to the Small Bowel and Serum Antibody Titers Correlate with Clinical Presentation of Patients with Celiac Disease. Clin Gastroenterol Hepatol 2013;11(2):166-171.
  • 29. Marsh MN, Heal CJ. Review Evolutionary Developments in Interpreting the Gluten-Induced Mucosal Celiac Lesion: An Archimedian Heuristic. Nutrients 2017;9(3):213.
  • 30. Çakmak A. Ankara'da Yaşayan 19-65 Yaş Arası Çölyak Hastalarının Beslenme Durumlarının Yaşam Kalitesi Üzerine Etkisi. Hacettepe Üniversitesi Sağlık Bilimleri Enstitüsü, Diyetetik Programı Yüksek Lisans Tezi, Ankara,2013.s.46-47.
  • 31. Prasad KK, Thapa BR, Nain CK, Singh K. The Frequency of Histologic Lesion Variability of The Duodenal Mucosa in Children With Celiac Disease.World J Pediatr 2010;6(1):60-64.
  • 32. Gupta P, Chhabra S, Singh S, Malhotra P, Sen R. A Study of Clinical, Serological and Histopathological Profile in Celiac Disease. International Journal of Current Research 2016;8(9):39403-39408.
There are 31 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Mahir Tayfur 0000-0001-7137-5465

Publication Date March 16, 2020
Submission Date October 16, 2019
Published in Issue Year 2020 Volume: 10 Issue: 1

Cite

AMA Tayfur M. Erzincan Mengücek Gazi Eğitim ve Araştırma Hastanesi’nde 2010-2018 Yılları Arasında Tanı Alan Erişkin Çölyak Hastalarının Değerlendirilmesi. Sakarya Tıp Dergisi. March 2020;10(1):37-43. doi:10.31832/smj.634047

30703

The published articles in SMJ are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.