The Effect of Anthracycline Chemotherapy on Arterial Stiffness

Year 2020, Volume: 10 Issue: 2, 191 - 196, 15.06.2020

Oguzhan Ekrem Turan , Mustafa Yılmaz Mürsel Şahin

https://doi.org/10.31832/smj.673754

Abstract

Objective: Anthracycline-derived chemotherapy for cancer treatment may cause dose-dependent irreversible heart failure. Arterial stifness is a predictor of cardiovascular events. We aimed to investigate the relationship between chemotherapy and arterial stiffness.

Material and Methods: Patients diagnosed non-Hodgkin's lymphoma, agreed to recieve anthracycline chemotherapy, were included in the study. Arterial stiffness was evaluated with applanation tonometer before, first and sixth cycles of chemotherapy.

Results: There was a tendency to increase first and sixth cycles pulse wave velocity values ​​before anthracycline chemotherapy [9.08 (8.12-9.76), 10.31 (8.22-12.62), 9.64 (8.22-12.62) m/s, p = 0.053] but those changes were not reach statistically significance. Augmentation index change did not significantly change between anthracycline chemotherapy cycles (p = 0.810). There was also a tendency to decrease first and sixth cycle subendocardial viabilty ratio values ​​before [151.60 (122.20-188.70) and after 124.30 (94.50-154.10), p = 0.058] chemotherapy.

Conclusion: Anthracycline chemotherapy tends to impaire arterial stiffness parameters

Keywords

Chemotherapy, arterial stiffness, anthracyclin

Project Number

Yok

Antrasiklin Kemoterapisinin Arteriyel Sertlik Üzerine Etkisi

Abstract

Öz:

Amaç: Kanser tedavisinde kullanılan antrasiklin türevli kemoterapi doz bağımlı olarak geri dönüşümsüz kalp yetersizliğine sebep olabilmektedir. Arteriyel sertlik kardiyovasküler olayların öngördürücüsüdür. Kemoterapi ile arteriyel sertlik arasındaki ilişkiyi araştırmak amaçlandı.

Gereç ve Yöntemler: Çalışmamıza, Hodgkin dışı lenfoma tanısı alan ve antrasiklin kemoterapisi alacak olan hastalar dahil edildi. Hastaların kemoterapi öncesi, ilk ve altıncı kür kemoterapi sonrası arteriyel sertlik aplanasyon tonometri ile değerlendirildi. 

Bulgular: Antrasiklin kemoterapi sonrası 1.kür ve 6.kür nabız dalga hızı değerlerinde bazale göre artış eğilimi vardı [9.08 (8.12-9.76), 10.31 (8.22-12.62), 9.64 (8.22-12.62) m/s, p = 0.053]. Antrasiklin kemoterapisiyle augmentasyon indeksinde anlamlı değişim olmadı (p=0.810). Tedavi öncesi bazal ve altıncı kür subendokardiyal viabilite oranı değerlerinde azalma eğilimi vardı [151.60 (122.20-188.70) and 124.30 (94.50-154.10), p = 0.058].

Sonuç: Antrasiklin kemoterapisi arteriyel sertlik parametlerini bozma eğilimi göstermektedir.

Keywords

Kemoterapi, Antrasiklin, Arteriyel Sertlik

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

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